Human | SFTPA1 | 653509 | surfactant protein A1 | Surfactant protein A (SP-A), expressed consistently less in bronchiolitis obliterans syndrome patients than in stable lung transplant recipients |
Human | NOD2 | 64127 | nucleotide-binding oligomerization domain containing 2 | Multivariate analysis proved recipient but not donor NOD-like receptor C2 (NOD2/CARD15) variants to be a novel independent risk factor for bronchiolitis obliterans |
Human | IL23A | 51561 | interleukin 23, alpha subunit p19 | The role of the IL23/IL17 axis in bronchiolitis obliterans syndrome after lung transplantation is reported |
Human | TNF | 7124 | tumor necrosis factor | Title:Interleukin-6 and interferon-gamma gene polymorphisms in the development of bronchiolitis obliterans syndrome after lung transplantation.|Association:Not Found|Conclusion:The presence of high-expression polymorphisms at position -174 of the IL-6 gene and position +874 of the IFN-gamma gene significantly increases the risk for BOS development after lung transplantation. |
Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | Significantly elevated tissue inhibitor of metalloproteinase 1 in broncho-alveolar lavage fluid is associated with Bronchiolitis obliterans |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | Title:Interleukin-6 and interferon-gamma gene polymorphisms in the development of bronchiolitis obliterans syndrome after lung transplantation.|Association:Not Found|Conclusion:The presence of high-expression polymorphisms at position -174 of the IL-6 gene and position +874 of the IFN-gamma gene significantly increases the risk for BOS development after lung transplantation. |
Human | PRDX2 | 7001 | peroxiredoxin 2 | Peroxiredoxin II (PRXII) exclusively expressed in bronchiolitis obliterans syndrome |
Human | SFTPD | 6441 | surfactant protein D | allogeneic hematopoietic stem-cell transplantation patients with lower pretransplant serum surfactant protein D (SP-D) level had a trend toward frequent development of Bronchiolitis obliterans syndrome and idiopathic pneumonia syndrome |
Human | MUC1 | 4582 | mucin 1, cell surface associated | Serum measurement has the potential to serve as a noninvasive diagnostic test for the detection of bronchiolitis obliterans syndrome in lung transplantation |
Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Significantly elevated metalloproteinase 9 in broncho-alveolar lavage fluid is associated with Bronchiolitis obliterans |
Human | MMP8 | 4317 | matrix metallopeptidase 8 (neutrophil collagenase) | Significantly elevated metalloproteinase 8 in broncho-alveolar lavage fluid is associated with Bronchiolitis obliterans |
Human | KIR2DS5 | 3810 | killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5 | Lack of activation KIR2DS5 may play an important role in the development of bronchiolitis obliterans but not in the control of cytomegalovirus reactivation after lung transplantation |
Human | IL17A | 3605 | interleukin 17A | Data suggest that IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants |
Human | IL10 | 3586 | interleukin 10 | Title:Interleukin-6 and interferon-gamma gene polymorphisms in the development of bronchiolitis obliterans syndrome after lung transplantation.|Association:Not Found|Conclusion:The presence of high-expression polymorphisms at position -174 of the IL-6 gene and position +874 of the IFN-gamma gene significantly increases the risk for BOS development after lung transplantation. |
Human | IL8 | 3576 | interleukin 8 | These results suggest that pulmonary neutrophils and IL-8, along with CD8+ T lymphocytes may play an important role in the pathogenesis of bronchiolitis obliterans after measles virus infection |
Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | The presence of high-expression polymorphisms at position -174 of the IL-6 gene significantly increases the risk for bronchiolitis obliterans syndrome development after lung transplantation Title:Interleukin-6 and interferon-gamma gene polymorphisms in the development of bronchiolitis obliterans syndrome after lung transplantation.|Association:Y|Conclusion:The presence of high-expression polymorphisms at position -174 of the IL-6 gene and position +874 of the IFN-gamma gene significantly increases the risk for BOS development after lung transplantation. |
Human | IFNG | 3458 | interferon, gamma | The presence of high-expression polymorphisms at position +874 of the IFN-gamma gene significantly increases the risk for bronchiolitis obliterans syndrome development after lung transplantation Title:Interleukin-6 and interferon-gamma gene polymorphisms in the development of bronchiolitis obliterans syndrome after lung transplantation.|Association:Y|Conclusion:The presence of high-expression polymorphisms at position -174 of the IL-6 gene and position +874 of the IFN-gamma gene significantly increases the risk for BOS development after lung transplantation. |
Human | CXCR3 | 2833 | chemokine (C-X-C motif) receptor 3 | Expression of CXCR3 ligands (MIG, IP-10, and ITAC) in the bronchoalveolar lavage fluid of transplantation recipients is associated with persistent recruitment of mononuclear cells, a pivotal event in the pathogenesis of bronchiolitis obliterans syndrome |
Human | TNFRSF8 | 943 | tumor necrosis factor receptor superfamily, member 8 | Soluble CD30 cannot be used as a biomarker to predict bronchiolitis obliterans after lung transplantation results strongly suggest sCD30 levels of lung transplant patients increase several months prior to clinical evidence of Bronchiolitis Obliterans Syndrome (BOS); rise in serum sCD30 levels can be used as a marker to detect patients at risk to develop BOS |
Human | CD28 | 940 | CD28 molecule | CD28 down-regulation on CD4 cells is associated with bronchiolitis obliterans syndrome and poor outcomes in lung transplantation recipients |