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human : 13
Thrombospondin, beta-thromboglobulin and platelet factor 4 were measured by radioimmunoassay in fluids from 50 human breast cysts.
|Human||HPGDS||27306||hematopoietic prostaglandin D synthase|
No significant associations were observed for either PEPC or PGDS concentration in breast cyst fluid and number of cysts, recurrence of the disease, family history of breast cancer, number of children, abortion, and breast feeding.
OBJECTIVE: To quantify pepsinogen C (PEPC) and prostaglandin D synthase (PGDS) in breast cyst fluid and examine if these two parameters can be used for breast cyst type classification.
DESIGN AND METHODS: We quantified PEPC and PGDS in 92 and 50 breast cyst fluids, respectively, using previously established immunofluorometric procedures.
Immunoreactive PGDS levels were highly correlated with a low cation ratio and were associated with the transudative/flattened type of breast cyst (Type II) (p = 0.0003).
CONCLUSIONS: Quantification of PEPC and PGDS in breast cyst fluid may be useful in the subclassification of cyst type in patients with gross cystic disease.
PEPC and PGDS levels were correlated with the breast cyst fluid cation ratio and were associated with the type of the cyst.
|Human||VCAM1||7412||vascular cell adhesion molecule 1|
Concentrations of soluble vascular cell adhesion molecule-1 and E-selectin in breast cyst fluid and their relation with cyst type.
|Human||TGFB2||7042||transforming growth factor, beta 2|
Latent forms of transforming growth factor-beta 2 (TGF-beta 2) in breast cyst fluid.
We found that TGF-beta 2 is present in high molecular weight, latent forms in breast cyst fluid: as a complex, probably with alpha 2-macroglobulin and a 56 kD protein which is likely to be a precursor form of TGF-beta 2.
The TGF-beta 2 isoform has been shown to be present in high concentrations in breast cyst fluid and might have a protective role in breast cancer.
The aim of the present study was to characterise the latent forms of TGF-beta 2 in breast cyst fluid using HPLC, affinity chromatography, SDS-PAGE and immunostaining techniques.
|Human||KLK6||5653||kallikrein-related peptidase 6|
Highest concentrations of hK6 were found in milk of lactating women, cerebral spinal fluid, nipple aspirate fluid, and breast cyst fluid.
|Human||PGC||5225||progastricsin (pepsinogen C)|
Quantification of pepsinogen C and prostaglandin D synthase in breast cyst fluid and their potential utility for cyst type classification.
We used this assay to measure pepsinogen C in seminal plasma, breast cyst fluid, amniotic fluid, male and female serum, serum from patients with prostate cancer, urine, breast tumor cytosolic extracts, breast milk, and cerebrospinal fluid.
Highest pepsinogen C concentrations were in seminal plasma, followed by breast cyst fluid and amniotic fluid.
Oncostatin M, interleukin 2, interleukin 6 and interleukin 8 in breast cyst fluid.
In this study, the concentrations of the cytokines, oncostatin M (OSM), interleukin 2 (IL-2), interleukin 6 (IL-6) and interleukin 8 (IL-8) were measured in breast cyst fluid, OSM, IL-2 and IL-6 having been shown to have growth-inhibitory actions on tumour cells.
|Human||IL1A||3552||interleukin 1, alpha|
No significant difference was found between IL-I alpha concentrations in the 2 groups of breast cysts.
|Human||IGFBP3||3486||insulin-like growth factor binding protein 3|
Insulin-like growth factor binding protein-3 in breast cyst fluid: relationships with insulin-like growth factors I and II and transforming growth factor-beta 1 and 2.
Augmented serum levels of the IGF-I/IGF-binding protein-3 ratio in pre-menopausal patients with type I breast cysts
Equimolar amounts of total IGFs and IGFBP-3 in breast cyst fluid imply that most, if not all, of these IGFs are protein-bound.
|Human||BMP6||654||bone morphogenetic protein 6|
A large collection of breast cyst fluid samples was analyzed for growth factors associated with cell proliferation: epidermal growth factor (EGF), insulin-like growth factor I (IGF-I), insulin-like growth factor II (IGF-II), platelet-derived growth factor (PDGF), transforming growth factor-alpha (TGF-alpha), and transforming growth factor-beta (TGF-beta).
|Human||AZGP1||563||alpha-2-glycoprotein 1, zinc-binding|
In addition, ZAG accumulates in fluids from breast cysts and in 40% of breast carcinomas, which suggests that ZAG plays a role in the development of breast diseases.
We purified human ZAG from breast cyst fluid and serum and produced a panel of anti-ZAG monoclonal antibodies.
The concentration of apoD in breast cyst fluids ranged from 6.82 to 28.37 mg/ml.
The present findings indicate that the direct sandwich DELFIA is appropriate for apoD quantification in plasma and breast cyst fluids.
|Human||ACPP||55||acid phosphatase, prostate|
presence of Prostatic Acid Phosphatase in breast cyst fluid may suggest its possible role in the development of breast cancer from cystic breast diseases