Logo arc image image
GATACA
  • Pin/Unpin Search
  • Pin/Unpin Details
Status:
Global Actions
Concepts: 0 (0)   Selected: 0 (0
Clear All Selections
 
Search
Text Search Results
Text Search Query:
none
Text Search Options:
none

Guided Help

Text Search Results
GraphTree Minimize or Maximize this Category
 Disease: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Anatomy: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Gene: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Jax Mouse Phenotype: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Human Phenotype: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Gene Ontology: Biological Processes: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Gene Ontology: Cellular Component: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Gene Ontology: Molecular Function: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Pathway: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Drug: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Genomic Expression Atlas --
      Microarray Datasets: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 PubMed: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 CoExpression Atlas: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 CoExpression: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Interactions: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Details
Link-It Detail - Disease - Malignant neoplasm of breast
Debug Stats
  • ### Total Build Time: 133 ms 53.736 KB
  • CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 354 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 1.682 KB
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=16 ms Completed: 16 ms rowSize= 15.438 KB
  • CONCEPT_GENES gt=113 ms Completed: 113 ms rowSize= 35.039 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.162 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Malignant neoplasm of breast C0006142
Definition (1)

Breast cancer affects one in eight women during their lives. Breast cancer kills more women in the United States than any cancer except lung cancer. No one knows why some women get breast cancer, but there are a number of risk factors. Risks that you cannot change include

  • Age - the chance of getting breast cancer rises as a woman gets older
  • Genes - there are two genes, BRCA1 and BRCA2, that greatly increase the risk. Women who have family members with breast or ovarian cancer may wish to be tested.
  • Personal factors - beginning periods before age 12 or going through menopause after age 55

Other risks include being overweight, using hormone replacement therapy (also called menopausal hormone therapy), taking birth control pills, drinking alcohol, not having children or having your first child after age 35 or having dense breasts.

Symptoms of breast cancer may include a lump in the breast, a change in size or shape of the breast or discharge from a nipple. Breast self-exam and mammography can help find breast cancer early when it is most treatable. Treatment may consist of radiation, lumpectomy, mastectomy, chemotherapy and hormone therapy.

Men can have breast cancer, too, but the number of cases is small.

NIH: National Cancer Institute

Relationships (60)

Relation Types:
diso_​to_​anat : 3
diso_​to_​chem : 2
diso_​to_​diso : 48
diso_​to_​gene : 6
diso_​to_​phys : 1


Relationships:
associated_​disease : 2
classified_​as : 13
gene_​associated_​with_​disease : 6
gene_​product_​is_​biomarker_​of : 1
gene_​product_​malfunction_​associated_​with_​disease : 1
has_​single_​level_​category : 1
is_​abnormal_​cell_​of_​disease : 2
is_​associated_​anatomic_​site_​of : 1
isa : 20
manifestation_​of : 9
related_​to : 3
used_​for : 1
Page Size
Current 25
  Page 1 of 3
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_associated_anatomic_site_ofimg Breast C0006141
DISO_to_ANATis_abnormal_cell_of_diseaseimg Cancer Cell C0334227
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_CHEMgene_product_is_biomarker_ofimg CYFRA 21-1 C0530993
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg Microsomal Epoxide Hydrolase C0026027
DISO_to_DISOassociated_diseaseimg Ataxia Telangiectasia C0004135
DISO_to_DISOisaimg BREAST CANCER, FAMILIAL C0346153
DISO_to_DISOrelated_toimg BREAST CANCER, FAMILIAL MALE C1861906
DISO_to_DISOisaimg Breast Adenomyoepithelioma with Malignant Change C1334564
DISO_to_DISOmanifestation_ofimg Breast Carcinoma C0678222
DISO_to_DISOrelated_toimg Breast Diseases C0006145
DISO_to_DISOisaimg Breast Lymphoma C1704251
DISO_to_DISOisaimg Breast Metastases C0346993
DISO_to_DISOused_forimg Breast Neoplasms C1458155
DISO_to_DISOisaimg Breast Sarcoma C0349667
DISO_to_DISOrelated_toimg Carcinoma of Male Breast C0238033
DISO_to_DISOmanifestation_ofimg Caused by mutation in the BRCA1-associated C-terminal helicase 1 gene (BRIP1, 605882.0001) C1861911
DISO_to_DISOmanifestation_ofimg Caused by mutation in the breast cancer type 1 gene (BRCA1, 113705.0001) C1861907
DISO_to_DISOmanifestation_ofimg Caused by mutation in the breast cancer type 2 gene (BRCA2, 600185.0001) C1861908
DISO_to_DISOmanifestation_ofimg Caused by mutation in the homolog of the S. cerevisiae RAD51A gene (RAD51A, 179617.0001) C1861912
DISO_to_DISOmanifestation_ofimg Caused by mutation in the solute carrier family 22, member 1-like gene (SLC22A1L, 602631.0001) C1861909
DISO_to_DISOmanifestation_ofimg Caused by mutation in the tumor protein p53 gene (TP53, 191170.0023) C1861910
DISO_to_DISOisaimg Hormone receptor positive malignant neoplasm of breast C1562029
DISO_to_DISOclassified_asimg Hx of breast malignancy C0260421
DISO_to_DISOassociated_diseaseimg Li-Fraumeni Syndrome C0085390
Genes (934)

Species:
human : 878
mouse : 56
Page Size
Current 25
  Page 1 of 38
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
MousePNCK139728pregnancy up-regulated non-ubiquitously expressed CaM kinase
img NCI, Score=801, Pubmed Id: 11034105, UMLKSK CUI: C0006142
MouseMYLK391807myosin light chain kinase 3
img NCI, Score=801, Pubmed Id: 15988034, UMLKSK CUI: C0006142
MouseSTRA664220stimulated by retinoic acid 6
img NCI, Score=801, Pubmed Id: 11358845, UMLKSK CUI: C0006142
MouseSPDEF25803SAM pointed domain containing ETS transcription factor
img NCI, Score=801, Pubmed Id: 14662758, UMLKSK CUI: C0006142
MouseSTARD1010809StAR-related lipid transfer (START) domain containing 10
img NCI, Score=801, Pubmed Id: 15150109, UMLKSK CUI: C0006142
MouseKDM5B10765lysine (K)-specific demethylase 5B
Click here to display 4 evidence detail records.
MouseKSR18844kinase suppressor of ras 1
img NCI, Score=801, Pubmed Id: 12874031, UMLKSK CUI: C0006142
img NCI, Score=801, Pubmed Id: 12874031, UMLKSK CUI: C0006142
MouseCXCR47852chemokine (C-X-C motif) receptor 4
img NCI, Score=801, Pubmed Id: 15574767, UMLKSK CUI: C0006142
MousePCGF27703polycomb group ring finger 2
img NCI, Score=801, Pubmed Id: 12196719, UMLKSK CUI: C0006142
MouseVIPR17433vasoactive intestinal peptide receptor 1
Click here to display 3 evidence detail records.
MouseUBE3A7337ubiquitin protein ligase E3A
img NCI, Score=801, Pubmed Id: 11072783, UMLKSK CUI: C0006142
MouseTIMP17076TIMP metallopeptidase inhibitor 1
img NCI, Score=801, Pubmed Id: 9683813, UMLKSK CUI: C0006142
MouseSTAT5A6776signal transducer and activator of transcription 5A
img NCI, Score=801, Pubmed Id: 12082622, UMLKSK CUI: C0006142
MouseSDC16382syndecan 1
img NCI, Score=801, Pubmed Id: 10888884, UMLKSK CUI: C0006142
img NCI, Score=801, Pubmed Id: 14681683, UMLKSK CUI: C0006142
MouseSCD6319stearoyl-CoA desaturase (delta-9-desaturase)
img NCI, Score=801, Pubmed Id: 1624, UMLKSK CUI: C0006142
MouseS100A46275S100 calcium binding protein A4
Click here to display 5 evidence detail records.
MouseROBO16091roundabout, axon guidance receptor, homolog 1 (Drosophila)
img NCI, Score=801, Pubmed Id: 17210685, UMLKSK CUI: C0006142
MousePTPRE5791protein tyrosine phosphatase, receptor type, E
img NCI, Score=801, Pubmed Id: 10602512, UMLKSK CUI: C0006142
MousePTGER35733prostaglandin E receptor 3 (subtype EP3)
img NCI, Score=801, Pubmed Id: 1849040, UMLKSK CUI: C0006142
MouseNOTCH44855notch 4
Click here to display 11 evidence detail records.
MouseNOTCH34854notch 3
img NCI, Score=801, Pubmed Id: 16507912, UMLKSK CUI: C0006142
MouseNOTCH14851notch 1
Click here to display 7 evidence detail records.
MouseMT1L4500metallothionein 1L (gene/pseudogene)
img NCI, Score=801, Pubmed Id: 3558400, UMLKSK CUI: C0006142
MouseMST1R4486macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Click here to display 3 evidence detail records.
MouseMGAT54249mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
img NCI, Score=801, Pubmed Id: 12122020, UMLKSK CUI: C0006142
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0006142Malignant neoplasm of breast0self