Mouse | PNCK | 139728 | pregnancy up-regulated non-ubiquitously expressed CaM kinase | Potentially related to its heterogeneous in vivo expression pattern, Pnck expression is oncogene-associated in murine epithelial cell lines derived from mammary tumors arising in different transgenic mouse models of breast cancer; cell lines derived from mammary tumors initiated by c-myc or int-2/Fgf3 express Pnck, whereas cell lines initiated by neu or H-ras do not. |
Mouse | MYLK3 | 91807 | myosin light chain kinase 3 | In vivo experiments showed that inhibiting MLCK increased the number of apoptotic cells and retarded the growth of mammary cancer cells in mice. |
Mouse | STRA6 | 64220 | stimulated by retinoic acid 6 | Up-regulation of Stra6 mRNA was also observed in hyperplastic mammary tissue and mammary gland tumors from transgenic mice expressing Wnt-1 and in human tumors that frequently harbor defects in Wnt-1 signaling. |
Mouse | SPDEF | 25803 | SAM pointed domain containing ETS transcription factor | Comparison of Ets factor expression in normal mammary tissue and mammary tumors identified significantly elevated expression of Pse/PDEF, Ese2/Elf5, Ese3/Ehf, TEL/Etv6, and Elf2/NERF in mammary tumors and confirmed previously reported alterations in expression of Ese1/Elf3 and the PEA3 subfamily. |
Mouse | STARD10 | 10809 | StAR-related lipid transfer (START) domain containing 10 | StarD10 was initially discovered on the basis of its cross-reactivity with a phosphoserine-specific antibody in mammary tumors from Neu/ErbB2 transgenic mice and subsequently isolated from SKBR3 human breast carcinoma cells using a multistep biochemical purification strategy. |
Mouse | KDM5B | 10765 | lysine (K)-specific demethylase 5B | Click here to display 4 evidence detail records. |
Mouse | KSR1 | 8844 | kinase suppressor of ras 1 | Hence, MT-driven mammary tumor genesis, which is signaled through src and phosphatidylinositol 3;-kinase, appears KSR1 independent, whereas v-Ha-ras-mediated skin cancer, signaled through the Raf-1/MAPK cascade, requires KSR1. Moreover, whereas the genesis of polyomavirus middle T antigen (MT)-driven mammary cancer appears independent of KSR1, KSR1 is obligate for v-Ha-ras-mediated skin tumor formation. |
Mouse | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | We used stable RNAi to reduce expression of CXCR4 in murine 4T1 cells, a highly metastatic mammary cancer cell line that is a model for stage IV human breast cancer. |
Mouse | PCGF2 | 7703 | polycomb group ring finger 2 | Murine mel-18 negatively regulates the cell cycle through the c-myc/cdc25 cascade, and mice haploinsufficient for mel-18 develop mammary gland tumors. |
Mouse | VIPR1 | 7433 | vasoactive intestinal peptide receptor 1 | Click here to display 3 evidence detail records. |
Mouse | UBE3A | 7337 | ubiquitin protein ligase E3A | The E6-AP overexpression in the mammary tumors is substantiated by western blot analysis and immunohistochemical analysis. |
Mouse | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | These data suggested that TIMP-1 overexpression may reduce local invasion and delay the progression of the metastatic disease in the present mammary tumor model. |
Mouse | STAT5A | 6776 | signal transducer and activator of transcription 5A | Loss of Stat5a delays mammary cancer progression in a mouse model. |
Mouse | SDC1 | 6382 | syndecan 1 | Here we have examined the role of syndecan-1 (encoded by Sdc1) during mammary tumour formation in response to the ectopic expression of the proto-oncogene Wnt1. Mice with a null mutation in the cell surface heparan sulfate (HS) proteoglycan, syndecan-1 (Sdc1), develop almost normally, but resist mammary tumor development in response to Wnt-1. |
Mouse | SCD | 6319 | stearoyl-CoA desaturase (delta-9-desaturase) | These observations suggest that (a) a major portion of the oleate in the mammary tumor is not produced within the tissue, (b) dietary adaptation is not a general characteristic of stearoyl-CoA desaturase in neoplastic tissues, and (c) enhanced desaturase activity in liver is directly related to the absence of linoleate or oleate, or to a large decrease in oleate in the diet. |
Mouse | S100A4 | 6275 | S100 calcium binding protein A4 | Click here to display 5 evidence detail records. |
Mouse | ROBO1 | 6091 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | Reduction of TGF-beta signaling by expression of a dominant-negative TGF-beta type II receptor in bigenic MMTV-Wnt1/DNIIR mice increased mammary tumor latency and was correlated with a decrease in expression of Gpc1, Inhba, and Robo1, three of the TGF-beta/Wnt cooperative targets. |
Mouse | PTPRE | 5791 | protein tyrosine phosphatase, receptor type, E | Protein tyrosine phosphatase epsilon increases the risk of mammary hyperplasia and mammary tumors in transgenic mice. |
Mouse | PTGER3 | 5733 | prostaglandin E receptor 3 (subtype EP3) | Role of the prostaglandin E2 receptor in mammary tumor metastasis. |
Mouse | NOTCH4 | 4855 | notch 4 | Click here to display 11 evidence detail records. |
Mouse | NOTCH3 | 4854 | notch 3 | Overexpression of activated murine notch1 and notch3 in transgenic mice blocks mammary gland development and induces mammary tumors. |
Mouse | NOTCH1 | 4851 | notch 1 | Click here to display 7 evidence detail records. |
Mouse | MT1L | 4500 | metallothionein 1L (gene/pseudogene) | Unfractionated nuclear extracts from the hepatoma or a rat mammary adenocarcinoma as well as whole cell extract obtained from the mammary tumor also transcribed MT-I gene. |
Mouse | MST1R | 4486 | macrophage stimulating 1 receptor (c-met-related tyrosine kinase) | Click here to display 3 evidence detail records. |
Mouse | MGAT5 | 4249 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | In addition, mammary tumors produced in Mgat5 gene knockout mice show markedly reduced metastases, indicating that it plays an important role in this process. |