human : 349
mouse : 5
|Mouse||DLL1||28514||delta-like 1 (Drosophila)|
In addition, pretreatment of glioma cells with Notch-1 or Delta-like-1 small interfering RNA significantly prolongs survival in a murine orthotopic brain tumor model.
|Mouse||SAG||6295||S-antigen; retina and pineal gland (arrestin)|
S-antigen and rod-opsin immunoreactions in midline brain neoplasms of transgenic mice: similarities to pineal cell tumors and certain medulloblastomas in man.
Neoplastic cells displaying immunoreactive S-antigen were found in five brain tumors; three of these tumors also contained a limited number of rod-opsin immunoreactive neoplastic cells.
|Mouse||RBP3||5949||retinol binding protein 3, interstitial|
Bilateral ocular and brain tumors (;trilateral;) were found in three other SV40 T-ag transgenic murine lines containing different promoters (murine interphotoreceptor retinoid-binding protein (IRBP), human IRBP, and alpha A-crystallin).
Differential expression of angiopoietin-1 and angiopoietin-2 may enhance recruitment of bone marrow-derived endothelial precursor cells into brain tumors.
DISCUSSION: The relative increase in angiopoietin-2 activity in brain tumors may result in the creation of a pro-angiogenic environment that enhances the recruitment of putative bone marrow-derived endothelial precursor cells into the tumor;s developing vascular tree.
In normal tissue directly surrounding the tumor, GFP+/CD34+ cells colocalized strongly with both angiopoietins (>75% and >70% for Ang-1 and Ang-2, respectively).DISCUSSION: The relative increase in angiopoietin-2 activity in brain tumors may result in the creation of a pro-angiogenic environment that enhances the recruitment of putative bone marrow-derived endothelial precursor cells into the tumor;s developing vascular tree.
|Mouse||PARP1||142||poly (ADP-ribose) polymerase 1|
Strikingly, PARP deficiency widens the tumor spectrum in mice deficient in p53, resulting in a high frequency of carcinomas in the mammary gland, lung, prostate, and skin, as well as brain tumors, reminiscent of Li-Fraumeni syndrome in humans.
Here we show that disruption of poly(ADP-ribose) polymerase (PARP-1) causes a high incidence (49%) of aggressive brain tumors in p53 null mice, with typical features of human cerebellar medulloblastomas.
Here we show that the highly malignant human brain tumor, glioblastoma, strongly overexpresses a specific miRNA, miR-21.
, Score=800, UMLKSK CUI: C0006118
|Human||SIRPA||140885||signal-regulatory protein alpha|
Expression of SIRPalpha1 on astrocytomas may be of considerable importance in brain tumor biology
Given the known role of SIRPalpha in regulating cell adhesion and responses to mitogenic growth factors, the expression of SIRPalpha1 on astrocytomas may be of considerable importance in brain tumor biology, and it offers the potential of a new avenue for therapeutic intervention.
|Human||HIST4H4||121504||histone cluster 4, H4|INFERRED
, Score=800, UMLKSK CUI: C0006118
|Human||OLIG1||116448||oligodendrocyte transcription factor 1|
We raised polyclonal antibodies against a synthetic peptide homologous to the human transcription factor Olig1 and studied by immunohistochemistry the expression of Olig1 in 84 brain tumors and in non-neoplastic brain tissues.
Analysis of the bHLH transcription factors Olig1 and Olig2 in brain tumors.
Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors.
To search for a differential expression of the OLIG genes in subgroups of brain tumors, the authors investigated OLIG1 and OLIG2 gene expression.
|Human||SAT2||112483||spermidine/spermine N1-acetyltransferase family member 2|
In order to establish a possible correlation between ganglioside expression in brain tumor and the activities of the enzymes involved in their metabolism, we analyzed the activities of specific sialyltransferases (SAT-1 and SAT-2), galactosyltransferase (GalT-4), N-acetylgalactosaminyltransferase (GalNAcT-1), and N-acetylglucosaminyltransferase (GlcNAcT-1) in 9 human meningiomas whose ganglioside pattern was characterized either by the predominance ganglioside GM3 (4 out of 9) or ganglioside GD3 (5 out of 9).
|Human||TUBA1C||84790||tubulin, alpha 1c|
These will boost the wide use of this useful class of compounds, i.e. in brain tumors as the most of the present active compounds have poor blood-brain barrier crossing ratios and also, various tubulin isotypes has shown resistance to taxanes and other antimitotic agents.
Most mechanisms of drugs which are used in brain tumor chemotherapy are well characterized: alkylation of DNA components (nitrosoureas), binding with tubulin protein resulting in metaphase arrest (vincristine), chromatid breaks and chromosome translocations (procarbazine), or inhibition of ribonucleotide reductase (hydroxyurea) .
These results may implicate NKX6B as a candidate tumor suppressor gene for brain tumors, particularly for oligodendrogliomas.
Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors.
|Human||INHBE||83729||inhibin, beta E|
To investigate the role of inhibin and activin in human brain tumors, the expression of inhibin alpha, and beta A mRNA as well as activin type II receptor (ACTR II) mRNA were studied in various human brain tumors.
|Human||PLVAP||83483||plasmalemma vesicle associated protein|
Plasmalemmal vesicle associated protein-1 has a role in brain tumor angiogenesis
|Human||MAGED4B||81557||melanoma antigen family D, 4B|
Detection of MAGE-1 tumor antigen in brain tumor.
We investigated the expression of MAGE-1 and -4 proteins in brain tumors with antibodies to recombinant MAGE-1 and -4 proteins.
|Human||WNT10A||80326||wingless-type MMTV integration site family, member 10A|
WNT10A mRNA was detected in 10 out of 12 esophageal cancer cell lines by cDNA-PCR, and was significantly up-regulated in esophageal cancer cell lines TE2, TE3, TE4, and a brain tumor cell line A-172.
Data show that L-2-hydroxyglutaric aciduria and brain tumors in children with mutations in the L2HGDH gene in exon 3 (c.292C-->T) and in exon 7 (c.887T-->A)
|Human||MMP25||64386||matrix metallopeptidase 25|
On the basis of these results, we propose that MT6-MMP may facilitate tumor progression through its ability to activate progelatinase A at the membrane of cells from colon carcinomas or brain tumors.
|Human||LRRC4||64101||leucine rich repeat containing 4|
LRRC4 is a novel relatively specific gene, which displays significant down-regulation in primary brain tumor biopsies and has the potential to suppress brain tumor growth.
Results showed that LRRC4 expression was limited to normal adult brain, both in human and in mouse, and exhibited a development-regulated pattern, but was down-regulated in brain tumor tissues and U251MG cell line.
This study was designed to investigate if LRRC4 has the potential of suppressing brain tumor growth.
|Human||ARHGAP23||57636||Rho GTPase activating protein 23|
ARHGAP23 mRNA was expressed in placenta, prostate, hippocampus, brain medulla as well as in brain tumor, salivary gland tumor, head and neck tumor.
|Human||PTCHD2||57540||patched domain containing 2|
DISP3 mRNA was expressed in human embryonic stem (ES) cells, brain, testis, lung carcinoid, neuroblastoma, retinoblastoma and brain tumor.
|Human||CYSLTR2||57105||cysteinyl leukotriene receptor 2|
Distribution of cysteinyl leukotriene receptor 2 in human traumatic brain injury and brain tumors.
|Human||SOX6||55553||SRY (sex determining region Y)-box 6|
Immunohistochemical analysis of SOX6 expression in human brain tumors.
|Human||BCAS3||54828||breast carcinoma amplified sequence 3|
BCAS3 is mis-expressed in brain tumors and could serve as a human ES cell and tumor marker