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Genes (67)
Species: human : 67 | |
Human | LOC100507436 | 100507436 | | association with Behcet's disease The study of MICA gene polymorphisms disclosed an independent association with genetic risk for juvenile Behcet disease A strong linkage disequilibrium was observed between the MICA*A6 and HLA-B51 in both the patients with Behcet's disease Among Indonesians,frequency of MICA-A9 allele,reported as negatively associated with Behcet's disease, was significantly higher; MICA-A6 allele frequency, reported as positively associated with Behcet's disease, was significantly lower among Japanese frequencies of MICA*009 and MICA*019 were significantly increased in Behcet's disease patients in comparison with controls; high-affinity alleles for NKG2D were not found in homozygous Behcet's disease patients polymorphism in Tunisian Behcet's disease patients This finding suggests that an association between MICA-A6 and BD (Behcet's disease) may be a secondary phenomenon related to HLA-B51 | Human | SUMO4 | 387082 | small ubiquitin-like modifier 4 | SUMO4 +438 C allele is associated with susceptibility to Behcet's Disease (BD) in HLA-B51 negative Chinese Han patients, while the AGAT haplotype is protectively associated with BD in HLA-B51 negative patients | Human | NOD2 | 64127 | nucleotide-binding oligomerization domain containing 2 | These findings suggest that 3 most common Crohn's Disease-predisposing CARD15 variants do not constitute a genetic susceptibility factor for Behcet's Disease in Turkey | Human | TLR9 | 54106 | toll-like receptor 9 | SNPs in the TLR9 gene were not significantly associated with susceptibility to Behcet's disease | Human | PTPN22 | 26191 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | Both the lower prevalence in the general population and the absence in Behcet's disease show the limited role of PTPN22 polymorphism in the pathogenesis of autoimmunity in Turkey study concludes that the presence of PTPN22 620W was inversely associated with Behcet's disease and the distribution of the SNP in the Middle East supports previous findings in the global prevalence | Human | TNFSF13B | 10673 | tumor necrosis factor (ligand) superfamily, member 13b | Serum BAFF (B-cell activating factor )levels were elevated in patients with active Behcets disease compared to the healthy controls, and correlated positively with the extent of skin lesions | Human | CXCL13 | 10563 | chemokine (C-X-C motif) ligand 13 | knee synovial fluid levels of CXCL 13 were higher in Rheumatoid arthritis and Behcets disease patients compared to Osteoarthritis patients | Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | there was no increase in serum adiponectin levels in patients with Behcets Syndrome or Rheumatoid Arthritis | Human | PROZ | 8858 | protein Z, vitamin K-dependent plasma glycoprotein | There is a positive correlation between the disease duration and protein Z levels in patients with Behcet's disease | Human | VWF | 7450 | von Willebrand factor | Elevated levels of plasma vWF anatigen are related to Behcet disease exacerbation rather than vascular involvement | Human | VEGFA | 7422 | vascular endothelial growth factor A | carriers of -634C and I alleles are associated with susceptibility to developing Behcet's disease elevation of VEGF (vascular endothelial growth factor) appears as a feature of inflammatory reaction during the course of Behcets disease, not a direct determinant of subclinical atherosclerosis | Human | TXK | 7294 | TXK tyrosine kinase | Th1 cells expressing Txk and Th1-associated cytokines may play a critical role in the development of skin and intestinal lesions in patients with Behcet's disease | Human | TNFRSF1B | 7133 | tumor necrosis factor receptor superfamily, member 1B | Serum levels and Adamantiades-Behcet's disease activity sTNFR1 and sTNFR2 were found at increased plasma concentrations in active Behcet's disease (BD), with the highest concentration in active BD with arthritis | Human | TNF | 7124 | tumor necrosis factor | there was no association between TNFA (tumor necrosis factor alpha) -308G/A, -238G/A, -857C/T or -863C/A polymorphisms or the -10131C allele and Behcet's disease The novel -646A TNFalpha allele was associated with the expression of HLA-B51 in Korean Behcet disease, although no genetic role of TNFalpha promoter polymorphisms was found in the susceptibility to Behcet's disease Findings indicate that TNFA haplotypes in the promoter response elements may exert significant influence on susceptibility to Behcet's Disease TNF-alpha production by peripheral blood monocytes in Behcet's disease patients who reported "bad" or "very bad" global well-being over the last month (n=4) was higher compared to other patients with better self-rating (p=0.03) No significant association was found between TNF-alpha 238 polymorphisms and nationality or in Behcets disease or health controls There is no association between TNF-alpha polymorphism and behcet disease | Human | TLR4 | 7099 | toll-like receptor 4 | one SNP in TLR4 is associated with Behcet's disease, and six SNPs have an effect on clinical features of Behcet's disease Upregulated TLR4 is associated with HO-1 reduction in peripheral blood monocytes from patients with Behcet's disease, leading to augmented inflammatory responses | Human | TLR2 | 7097 | toll-like receptor 2 | Decreased TLR-2 (toll-like receptor 2) expression was noted in monocytes of Behcets disease patients | Human | THBD | 7056 | thrombomodulin | Behcet's disease with vascular complications involves higher levels of thrombomodulin | Human | TRG@ | 6965 | | T-gamma receptor restriction in peripheral lymphocytes of patients with Behcet's disease | Human | TRD@ | 6964 | | T-delta receptor restriction in peripheral lymphocytes of patients with Behcet's disease | Human | SOD2 | 6648 | superoxide dismutase 2, mitochondrial | Extracellular SOD, endothelial NOS, and inducible NOS gene polymorphisms do not constitute a risk factor for developing BD (Behcet disease) in Japan | Human | SLC11A1 | 6556 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 | The allele 3 and the genotype allele 3/allele 3 of the 5'-promoter (GT)n in the SLC11A1 gene may have a protective effect for the development of Behcet's disease in the Korean population | Human | SELL | 6402 | selectin L | expression on leukocytes in Behcet's disease | Human | CXCL12 | 6387 | chemokine (C-X-C motif) ligand 12 | knee synovial fluid levels of CXCL 12 were higher in Rheumatoid arthritis and Behcets disease patients compared to Osteoarthritis patients | Human | CCL21 | 6366 | chemokine (C-C motif) ligand 21 | knee synovial fluid CCL 21 levels were found to be increased in Rheumatoid arthritis patients as compared to Behcets disease and osteoarthritis patients | Human | SAG | 6295 | S-antigen; retina and pineal gland (arrestin) | S-Ag specific T cells are present in certain active Behcet's disease patients, and most of them are activated memory CD4(+) T cells |
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