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Details
Link-It Detail - Disease - Arthritis, Rheumatoid
Debug Stats
  • ### Total Build Time: 186 ms 62.562 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 390 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 488 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=6 ms Completed: 6 ms rowSize= 188 bytes
  • CONCEPT_NAMESPACE gt=NONE 1 ms Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 1.386 KB
  • CONCEPT_CHILDREN gt=3 ms Completed: 3 ms rowSize= 3.115 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 5.335 KB
  • CONCEPT_RELATIONSHIPS gt=124 ms Completed: 124 ms rowSize= 15.887 KB
  • CONCEPT_GENES gt=47 ms Completed: 47 ms rowSize= 34.616 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.155 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (2)
Arthritis, Rheumatoid C0003873
Rheumatoid Arthritis
Definition (1)
chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures; etiology is unknown, but autoimmune mechanisms have been implicated.
Semantic Types (1)
Disease or Syndrome (T047)
Parents (3)
img Arthritis C0003864
img Autoimmune Diseases C0004364
img Rheumatic Diseases C0035435
Children (7)
img Stills Disease, Adult-Onset C0085253
img Sjogrens Syndrome C1527336
img Arthritis, Juvenile Rheumatoid C0553662
img Rheumatoid Vasculitis C0240903
img Caplan Syndrome C0006915
img Rheumatoid Nodule C0035450
img Felty Syndrome C0015773
Ancestral Roots
RootRoot Plus OneDepthParent
img Musculoskeletal Diseases C0026857img Joint Diseases C00224084img Arthritis C0003864
img Immune System Diseases C0021053img Autoimmune Diseases C00043643img Autoimmune Diseases C0004364
img Musculoskeletal Diseases C0026857img Rheumatic Diseases C00354353img Rheumatic Diseases C0035435
img Skin and Connective Tissue Diseases C0175166img Connective Tissue Diseases C00097824img Rheumatic Diseases C0035435
Relationships (551)

Relation Types:
diso_​to_​anat : 60
diso_​to_​chem : 308
diso_​to_​diso : 154
diso_​to_​gene : 10
diso_​to_​phen : 3
diso_​to_​phys : 16


Relationships:
none : 286
associated_​with : 7
classifies : 1
clinically_​similar : 17
gene_​associated_​with_​disease : 8
gene_​product_​malfunction_​associated_​with_​disease : 1
is_​associated_​anatomic_​site_​of : 1
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 12
location_​of : 1
mapped_​to : 23
may_​treat : 188
related_​to : 5
Page Size
Current 25
  Page 1 of 23
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_CHEM2531img Antirheumatic Agents C0003191
DISO_to_DISO1868img Complication Aspects C1171258
DISO_to_CHEM1553img Antirheumatic Agents C0003191
DISO_to_DISO1284img Complication Aspects C1171258
DISO_to_PHEN1258img genetic aspects C0017399
DISO_to_ANAT1086img In Blood C0005768
DISO_to_CHEM1015img Antibodies, Monoclonal C0003250
DISO_to_CHEM884img Tumor Necrosis Factor-alpha C1456820
DISO_to_PHEN753img genetic aspects C0017399
DISO_to_ANAT661img In Blood C0005768
DISO_to_CHEM638img Antibodies, Monoclonal C0003250
DISO_to_ANAT556img Synovial Membrane C0039099
DISO_to_CHEM524img Tumor Necrosis Factor-alpha C1456820
DISO_to_CHEM514img Methotrexate C0025677
DISO_to_ANAT497img Synovial Membrane C0039099
DISO_to_CHEM395img Abs - Autoantibodies C0004358
DISO_to_CHEM394img Methotrexate C0025677
DISO_to_CHEM390img Immunoglobulin G C0020852
DISO_to_CHEM341img Cyclic Peptides C0030957
DISO_to_DISO291img Degenerative polyarthritis C0029408
DISO_to_DISO272img Degenerative polyarthritis C0029408
DISO_to_CHEM266img Immunoglobulin G C0020852
DISO_to_GENE261img Polymorphism, Single Nucleotide C0752046
DISO_to_CHEM253img Receptors, Tumor Necrosis Factor C0077503
DISO_to_CHEM250img Abs - Autoantibodies C0004358
Genes (376)

Species:
human : 376
Page Size
Current 25
  Page 1 of 16
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanLOC100507436100507436
Click here to display 5 evidence detail records.
HumanKIR2DS2100132285killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
img GAD, Score=1000, Pubmed Id: 11369787, UMLKSK CUI: C0003873
img GENERIF, Score=1000, Pubmed Id: 17497034, UMLKSK CUI: C0003873
HumanCCR2729230chemokine (C-C motif) receptor 2
img GENERIF, Score=901, Pubmed Id: 19017998, UMLKSK CUI: C0003873
HumanMIR16-1406950
img GENERIF, Score=660, Pubmed Id: 18759964, UMLKSK CUI: C0003873
HumanMIR146A406938microRNA 146a
img GENERIF, Score=1000, Pubmed Id: 18759964, UMLKSK CUI: C0003873
img GENERIF, Score=1000, Pubmed Id: 18383392, UMLKSK CUI: C0003873
HumanNCR3259197natural cytotoxicity triggering receptor 3
img GENERIF, Score=694, Pubmed Id: 16362817, UMLKSK CUI: C0003873
HumanAQPEP206338laeverin
img GENERIF, Score=1000, Pubmed Id: 16804865, UMLKSK CUI: C0003873
HumanNEWENTRY192343Record to support submission of GeneRIFs for a gene not in Gene (human; man).
img GENERIF, Score=1000, Pubmed Id: 18668562, UMLKSK CUI: C0003873
img GENERIF, Score=673, Pubmed Id: 17911417, UMLKSK CUI: C0003873
HumanIL23R149233interleukin 23 receptor
img GENERIF, Score=1000, Pubmed Id: 17606463, UMLKSK CUI: C0003873
img GENERIF, Score=1000, Pubmed Id: 18512797, UMLKSK CUI: C0003873
img GENERIF, Score=734, Pubmed Id: 17678723, UMLKSK CUI: C0003873
HumanTNFRSF13C115650tumor necrosis factor receptor superfamily, member 13C
img GENERIF, Score=1000, Pubmed Id: 17963166, UMLKSK CUI: C0003873
HumanFCRL3115352Fc receptor-like 3
Click here to display 5 evidence detail records.
HumanMIR155HG114614MIR155 host gene (non-protein coding)
img GENERIF, Score=1000, Pubmed Id: 18383392, UMLKSK CUI: C0003873
HumanNLRP3114548NLR family, pyrin domain containing 3
img GENERIF, Score=1000, Pubmed Id: 19001869, UMLKSK CUI: C0003873
HumanHAVCR284868hepatitis A virus cellular receptor 2
img GENERIF, Score=1000, Pubmed Id: 15325803, UMLKSK CUI: C0003873
img GAD, Score=1000, Pubmed Id: 15325803, UMLKSK CUI: C0003873
HumanFCRLA84824Fc receptor-like A
img GENERIF, Score=1000, Pubmed Id: 12966588, UMLKSK CUI: C0003873
HumanSYVN184447synovial apoptosis inhibitor 1, synoviolin
img GENERIF, Score=1000, Pubmed Id: 16786162, UMLKSK CUI: C0003873
img GENERIF, Score=1000, Pubmed Id: 18235538, UMLKSK CUI: C0003873
HumanITCH83737itchy E3 ubiquitin protein ligase
img GENERIF, Score=734, Pubmed Id: 19001863, UMLKSK CUI: C0003873
HumanJAM383700junctional adhesion molecule 3
img GENERIF, Score=734, Pubmed Id: 18821692, UMLKSK CUI: C0003873
HumanISCA181689iron-sulfur cluster assembly 1
INFERRED, Score=800, UMLKSK CUI: C0003873
HumanCD27680381CD276 molecule
img GENERIF, Score=1000, Pubmed Id: 18292521, UMLKSK CUI: C0003873
HumanPDCD1LG280380programmed cell death 1 ligand 2
img GENERIF, Score=1000, Pubmed Id: 17597384, UMLKSK CUI: C0003873
HumanENGASE64772endo-beta-N-acetylglucosaminidase
img GENERIF, Score=734, Pubmed Id: 12905469, UMLKSK CUI: C0003873
HumanNOD264127nucleotide-binding oligomerization domain containing 2
img GENERIF, Score=734, Pubmed Id: 16134725, UMLKSK CUI: C0003873
HumanMRPL1763875mitochondrial ribosomal protein L17
img GENERIF, Score=734, Pubmed Id: 18162190, UMLKSK CUI: C0003873
HumanEXOC460412exocyst complex component 4
img GAD, Score=1000, Pubmed Id: 15880602, UMLKSK CUI: C0003873
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0003873Arthritis, Rheumatoid0self