| Human | LOC100507436 | 100507436 | | Click here to display 5 evidence detail records. |
| Human | KIR2DS2 | 100132285 | killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 | Title:Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis.|Association:Y|Conclusion:These data suggest that HLA class I-recognizing receptors and HLA class I genes are genetic risk determinants that modulate the pattern of RA expression. Specifically, KIR2DS2 in conjunction with the appropriate HLA-C ligand may have a role in vascular damage by regulating CD4(+)CD28(null) T cells. Data show that there was no correlation between CD158b expression and disease activity in rheumatoid arthritis |
| Human | CCR2 | 729230 | chemokine (C-C motif) receptor 2 | infiltrated neutrophils from patients with chronic inflammatory lung diseases and rheumatoid arthritis highly express CCR1, CCR2, CCR3, CCR5, CXCR3, and CXCR4 |
| Human | MIR16-1 | 406950 | | Rheumatoid arthritis peripheral blood mononuclear cells exhibited increases in miR-146a, miR-155, miR-132, and miR-16 expression, whereas let-7a expression was not significantly different compared with healthy control individuals |
| Human | MIR146A | 406938 | microRNA 146a | synovial fibroblasts showed increased expression of miRNA miR-155 (microRNA 155) and miR-146a (microRNA 146a) in Rheumatoid Arthritis miR-146a expression is increased but unable to properly function, leading to prolonged tumor necrosis factor-alpha production in patients with rheumatoid arthritis |
| Human | NCR3 | 259197 | natural cytotoxicity triggering receptor 3 | The expression of LST1, specifically splice variants encoding soluble isoforms and NCR3, was increased in rheumatoid-arthritis-affected blood and synovium and was associated with more severe inflammation in the synovium |
| Human | AQPEP | 206338 | laeverin | The 3 most significantly overexpressed genes in rheumatoid arthritis were laeverin, 11beta-hydroxysteroid dehydrogenase type 2 (a steroid pathway enzyme), and cysteine-rich, angiogenic inducer 61 (a known angiogenic factor) |
| Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | may significantly contribute to the genetic determination of anti-cyclic citrullinated peptide production in Hungarian patients with rheumatoid arthritis[cyclic citrullinated peptide ] Citrullinated polypeptides (CCP-2) were detected in the synovial fluid from patients with rheumatoid arthritis and patients with spondylarthritides [CCP-2] |
| Human | IL23R | 149233 | interleukin 23 receptor | We conclude that the IL23R gene does not seem to be associated with rheumatoid arthritis predisposition in a Spanish population The data reported provide direct evidence that some allelic variants or haplogroups of IL-23R represent independent risk factors for rheumatoid arthritis as well as Crohn's disease, but not for scleroderma interleukin23R (IL23R)variants are not associated with rheumatoid arthritis |
| Human | TNFRSF13C | 115650 | tumor necrosis factor receptor superfamily, member 13C | Widely expressed in the synovial tissue of patients with rheumatoid arthritis |
| Human | FCRL3 | 115352 | Fc receptor-like 3 | Click here to display 5 evidence detail records. |
| Human | MIR155HG | 114614 | MIR155 host gene (non-protein coding) | synovial fibroblasts showed increased expression of miRNA miR-155 (microRNA 155) and miR-146a (microRNA 146a) in Rheumatoid Arthritis |
| Human | NLRP3 | 114548 | NLR family, pyrin domain containing 3 | significant KPNA1-, NLRP1- and NLRP3-gene expression phenotypes associated with human genotypes of Crohn's disease, Huntington's disease and rheumatoid arthritis |
| Human | HAVCR2 | 84868 | hepatitis A virus cellular receptor 2 | Title:The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis.|Association:Not Found|Conclusion:These results strongly suggest that -574T>G and 4259G>T polymorphism of the Tim-3 might be associated with susceptibility to RA. Tim-3 gene associated with rheumatoid arthritis |
| Human | FCRLA | 84824 | Fc receptor-like A | The concentration of FREB FCRL in patients with rheumatoid arthritis is three times higher than in healthy adults |
| Human | SYVN1 | 84447 | synovial apoptosis inhibitor 1, synoviolin | overexpressed in the synovial cells of patients with rheumatoid arthritis, resulting in a state in which the cell deals with accumulated unfolded proteins excessively Results showed that Synoviolin, a novel causative factor for rheumatoid arthritis, is up-regulated in proliferating synovial cells in the disease |
| Human | ITCH | 83737 | itchy E3 ubiquitin protein ligase | Itch gene sequence is highly conserved in healthy subjects; no relevant SNPs located in putative functional regions of Itch were found in atopic dermatitis and rheumatoid arthritis patients |
| Human | JAM3 | 83700 | junctional adhesion molecule 3 | JAM-C *junctional adhesion molecule C) mediates recruiting and retaining leukocytes in the Rheumatoid arthritis synovium |
| Human | ISCA1 | 81689 | iron-sulfur cluster assembly 1 | INFERRED, Score=800, UMLKSK CUI: C0003873 |
| Human | CD276 | 80381 | CD276 molecule | B7-H3 may be important for the interactions between fibroblast-like synoviocytes and T cells in rheumatoid arthritis and other diseases; the outcome of such interactions depends on the activation state of the T cell |
| Human | PDCD1LG2 | 80380 | programmed cell death 1 ligand 2 | Polymorphisms of PD-L2 are not associated with susceptibility to rheumatoid arthritis in Taiwan |
| Human | ENGASE | 64772 | endo-beta-N-acetylglucosaminidase | endo-beta-n-acetylglucosaminidase present in the synovial fluid of rheumatoid arthritis patients, may contribute to the depletion of glycosaminoglycans from cartilage allowing the invasion of synovial cells |
| Human | NOD2 | 64127 | nucleotide-binding oligomerization domain containing 2 | These data suggest that CARD15 variants are not associated with rheumatoid arthritis susceptibility |
| Human | MRPL17 | 63875 | mitochondrial ribosomal protein L17 | High levels of LIP2 were found in serum and synovial fluid of rheumatoid arthritis patients, providing evidence for a cytokine-like role |
| Human | EXOC4 | 60412 | exocyst complex component 4 | Title:Association between single-nucleotide polymorphisms in the SEC8L1 gene, which encodes a subunit of the exocyst complex, and rheumatoid arthritis in a Japanese population.|Association:Y|Conclusion:Our locus-wide association and LD analyses identified intronic SNPs and haplotypes in the SEC8L1 gene that are strongly associated with RA. We propose that SEC8L1, which encodes a component of the exocyst complex, is a candidate susceptibility gene for RA in the Japanese population. |