Human | LOC100507436 | 100507436 | | Click here to display 5 evidence detail records. |
Human | KIR2DS2 | 100132285 | killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 | Title:Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis.|Association:Y|Conclusion:These data suggest that HLA class I-recognizing receptors and HLA class I genes are genetic risk determinants that modulate the pattern of RA expression. Specifically, KIR2DS2 in conjunction with the appropriate HLA-C ligand may have a role in vascular damage by regulating CD4(+)CD28(null) T cells. Data show that there was no correlation between CD158b expression and disease activity in rheumatoid arthritis |
Human | CCR2 | 729230 | chemokine (C-C motif) receptor 2 | infiltrated neutrophils from patients with chronic inflammatory lung diseases and rheumatoid arthritis highly express CCR1, CCR2, CCR3, CCR5, CXCR3, and CXCR4 |
Human | MIR16-1 | 406950 | | Rheumatoid arthritis peripheral blood mononuclear cells exhibited increases in miR-146a, miR-155, miR-132, and miR-16 expression, whereas let-7a expression was not significantly different compared with healthy control individuals |
Human | MIR146A | 406938 | microRNA 146a | miR-146a expression is increased but unable to properly function, leading to prolonged tumor necrosis factor-alpha production in patients with rheumatoid arthritis synovial fibroblasts showed increased expression of miRNA miR-155 (microRNA 155) and miR-146a (microRNA 146a) in Rheumatoid Arthritis |
Human | NCR3 | 259197 | natural cytotoxicity triggering receptor 3 | The expression of LST1, specifically splice variants encoding soluble isoforms and NCR3, was increased in rheumatoid-arthritis-affected blood and synovium and was associated with more severe inflammation in the synovium |
Human | AQPEP | 206338 | laeverin | The 3 most significantly overexpressed genes in rheumatoid arthritis were laeverin, 11beta-hydroxysteroid dehydrogenase type 2 (a steroid pathway enzyme), and cysteine-rich, angiogenic inducer 61 (a known angiogenic factor) |
Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | Citrullinated polypeptides (CCP-2) were detected in the synovial fluid from patients with rheumatoid arthritis and patients with spondylarthritides [CCP-2] may significantly contribute to the genetic determination of anti-cyclic citrullinated peptide production in Hungarian patients with rheumatoid arthritis[cyclic citrullinated peptide ] |
Human | IL23R | 149233 | interleukin 23 receptor | The data reported provide direct evidence that some allelic variants or haplogroups of IL-23R represent independent risk factors for rheumatoid arthritis as well as Crohn's disease, but not for scleroderma interleukin23R (IL23R)variants are not associated with rheumatoid arthritis We conclude that the IL23R gene does not seem to be associated with rheumatoid arthritis predisposition in a Spanish population |
Human | TNFRSF13C | 115650 | tumor necrosis factor receptor superfamily, member 13C | Widely expressed in the synovial tissue of patients with rheumatoid arthritis |
Human | FCRL3 | 115352 | Fc receptor-like 3 | Click here to display 5 evidence detail records. |
Human | MIR155HG | 114614 | MIR155 host gene (non-protein coding) | synovial fibroblasts showed increased expression of miRNA miR-155 (microRNA 155) and miR-146a (microRNA 146a) in Rheumatoid Arthritis |
Human | NLRP3 | 114548 | NLR family, pyrin domain containing 3 | significant KPNA1-, NLRP1- and NLRP3-gene expression phenotypes associated with human genotypes of Crohn's disease, Huntington's disease and rheumatoid arthritis |
Human | HAVCR2 | 84868 | hepatitis A virus cellular receptor 2 | Tim-3 gene associated with rheumatoid arthritis Title:The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis.|Association:Not Found|Conclusion:These results strongly suggest that -574T>G and 4259G>T polymorphism of the Tim-3 might be associated with susceptibility to RA. |
Human | FCRLA | 84824 | Fc receptor-like A | The concentration of FREB FCRL in patients with rheumatoid arthritis is three times higher than in healthy adults |
Human | SYVN1 | 84447 | synovial apoptosis inhibitor 1, synoviolin | Results showed that Synoviolin, a novel causative factor for rheumatoid arthritis, is up-regulated in proliferating synovial cells in the disease overexpressed in the synovial cells of patients with rheumatoid arthritis, resulting in a state in which the cell deals with accumulated unfolded proteins excessively |
Human | ITCH | 83737 | itchy E3 ubiquitin protein ligase | Itch gene sequence is highly conserved in healthy subjects; no relevant SNPs located in putative functional regions of Itch were found in atopic dermatitis and rheumatoid arthritis patients |
Human | JAM3 | 83700 | junctional adhesion molecule 3 | JAM-C *junctional adhesion molecule C) mediates recruiting and retaining leukocytes in the Rheumatoid arthritis synovium |
Human | ISCA1 | 81689 | iron-sulfur cluster assembly 1 | INFERRED, Score=800, UMLKSK CUI: C0003873 |
Human | CD276 | 80381 | CD276 molecule | B7-H3 may be important for the interactions between fibroblast-like synoviocytes and T cells in rheumatoid arthritis and other diseases; the outcome of such interactions depends on the activation state of the T cell |
Human | PDCD1LG2 | 80380 | programmed cell death 1 ligand 2 | Polymorphisms of PD-L2 are not associated with susceptibility to rheumatoid arthritis in Taiwan |
Human | ENGASE | 64772 | endo-beta-N-acetylglucosaminidase | endo-beta-n-acetylglucosaminidase present in the synovial fluid of rheumatoid arthritis patients, may contribute to the depletion of glycosaminoglycans from cartilage allowing the invasion of synovial cells |
Human | NOD2 | 64127 | nucleotide-binding oligomerization domain containing 2 | These data suggest that CARD15 variants are not associated with rheumatoid arthritis susceptibility |
Human | MRPL17 | 63875 | mitochondrial ribosomal protein L17 | High levels of LIP2 were found in serum and synovial fluid of rheumatoid arthritis patients, providing evidence for a cytokine-like role |
Human | EXOC4 | 60412 | exocyst complex component 4 | Title:Association between single-nucleotide polymorphisms in the SEC8L1 gene, which encodes a subunit of the exocyst complex, and rheumatoid arthritis in a Japanese population.|Association:Y|Conclusion:Our locus-wide association and LD analyses identified intronic SNPs and haplotypes in the SEC8L1 gene that are strongly associated with RA. We propose that SEC8L1, which encodes a component of the exocyst complex, is a candidate susceptibility gene for RA in the Japanese population. |