Logo arc image image
GATACA
  • Pin/Unpin Search
  • Pin/Unpin Details
Status:
Global Actions
Concepts: 0 (0)   Selected: 0 (0
Clear All Selections
 
Search
Text Search Results
Text Search Query:
none
Text Search Options:
none

Guided Help

Text Search Results
GraphTree Minimize or Maximize this Category
 Disease: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Anatomy: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Gene: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Jax Mouse Phenotype: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Human Phenotype: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Gene Ontology: Biological Processes: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Gene Ontology: Cellular Component: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Gene Ontology: Molecular Function: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Pathway: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Drug: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Genomic Expression Atlas --
      Microarray Datasets: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 PubMed: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 CoExpression Atlas: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 CoExpression: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Interactions: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Details
Link-It Detail - Disease - Primary Myelofibrosis
Debug Stats
  • ### Total Build Time: 256 ms 63.022 KB
  • CONCEPT_NAME gt=6 ms Completed: 6 ms rowSize= 340 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 364 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=14 ms Completed: 14 ms rowSize= 564 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.523 KB
  • CONCEPT_RELATIONSHIPS gt=186 ms Completed: 186 ms rowSize= 16.392 KB
  • CONCEPT_GENES gt=40 ms Completed: 40 ms rowSize= 42.495 KB
  • CONCEPT_XREFS gt=8 ms Completed: 8 ms rowSize= 1.155 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Primary Myelofibrosis C0001815
Definition (1)
A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Myeloproliferative Disorders C0027022
Ancestral Roots
RootRoot Plus OneDepthParent
img Hemic and Lymphatic Diseases C0018981img Hematologic Diseases C00189395img Myeloproliferative Disorders C0027022
Relationships (79)

Relation Types:
diso_​to_​anat : 18
diso_​to_​chem : 19
diso_​to_​diso : 35
diso_​to_​phen : 3
diso_​to_​phys : 4


Relationships:
none : 44
clinically_​similar : 3
is_​abnormal_​cell_​of_​disease : 4
is_​associated_​anatomic_​site_​of : 1
is_​finding_​of_​disease : 3
is_​normal_​cell_​origin_​of_​disease : 2
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​cytogenetic_​abnormality_​of_​disease : 2
is_​not_​finding_​of_​disease : 1
is_​not_​molecular_​abnormality_​of_​disease : 1
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 2
mapped_​to : 2
may_​be_​cytogenetic_​abnormality_​of_​disease : 5
may_​be_​finding_​of_​disease : 1
may_​be_​molecular_​abnormality_​of_​disease : 1
may_​treat : 3
related_​to : 1
Page Size
Current 25
  Page 1 of 4
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_PHEN186img genetic aspects C0017399
DISO_to_DISO142img Complication Aspects C1171258
DISO_to_DISO138img Complication Aspects C1171258
DISO_to_CHEM92img Janus Kinase 2 C0169661
DISO_to_PHEN81img genetic aspects C0017399
DISO_to_DISO75img Thrombocythemia, Essential C0040028
DISO_to_DISO72img Polycythemia Vera C0032463
DISO_to_ANAT57img In Blood C0005768
DISO_to_ANAT39img Bone Marrow C0005953
DISO_to_PHYS38img Mutation C0026882
DISO_to_ANAT35img In Blood C0005768
DISO_to_PHYS30img Hematopoiesis, Extramedullary C0018952
DISO_to_CHEM26img Protein Kinase Inhibitors C1449702
DISO_to_PHYS26img Extramedullary Hematopoiesis Function C0018952
DISO_to_DISO25img Polycythemia Vera C0032463
DISO_to_ANAT24img Bone Marrow C0005953
DISO_to_CHEM22img Receptors, Thrombopoietin C1706293
DISO_to_DISO22img ESSENTIAL THROMBOCYTHEMIA C0040028
DISO_to_DISO22img Leukemia, Myelocytic, Acute C0023467
DISO_to_CHEM21img Antineoplastic Agents C0003392
DISO_to_CHEM20img (+)-Thalidomide C0039736
DISO_to_CHEM20img Pyrazole Compound C0034242
DISO_to_CHEM20img Pyrazoles C0034242
DISO_to_CHEM20img Thalidomide C0039736
DISO_to_DISO20img Dysmyelopoietic Syndromes C0026986
Genes (45)

Species:
human : 45
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanZFPM1161882zinc finger protein, FOG family member 1
img GENERIF, Score=734, Pubmed Id: 16127162, UMLKSK CUI: C0001815
HumanCD17757126CD177 molecule
img NCI, Score=801, Pubmed Id: 12377969, UMLKSK CUI: C0001815
HumanNOG9241noggin
img GENERIF, Score=1000, Pubmed Id: 17889703, UMLKSK CUI: C0001815
HumanSOCS39021suppressor of cytokine signaling 3
img GENERIF, Score=1000, Pubmed Id: 18815196, UMLKSK CUI: C0001815
HumanD13S258101Disrupted in B-cell neoplasia
img NCI, Score=801, Pubmed Id: 11380400, UMLKSK CUI: C0001815
img NCI, Score=801, Pubmed Id: 11380400, UMLKSK CUI: C0001815
HumanHMGA28091high mobility group AT-hook 2
img GENERIF, Score=1000, Pubmed Id: 14603445, UMLKSK CUI: C0001815
HumanCXCR47852chemokine (C-X-C motif) receptor 4
img GENERIF, Score=1000, Pubmed Id: 17350297, UMLKSK CUI: C0001815
img GENERIF, Score=1000, Pubmed Id: 18206727, UMLKSK CUI: C0001815
img GENERIF, Score=1000, Pubmed Id: 18511598, UMLKSK CUI: C0001815
HumanVEGFA7422vascular endothelial growth factor A
img GENERIF, Score=1000, Pubmed Id: 15613104, UMLKSK CUI: C0001815
HumanTGFB17040transforming growth factor, beta 1
img GENERIF, Score=1000, Pubmed Id: 17157157, UMLKSK CUI: C0001815
img GENERIF, Score=923, Pubmed Id: 14991065, UMLKSK CUI: C0001815
HumanTAC16863tachykinin, precursor 1
img GENERIF, Score=1000, Pubmed Id: 12486316, UMLKSK CUI: C0001815
HumanSTAT5B6777signal transducer and activator of transcription 5B
img NCI, Score=801, Pubmed Id: 12842707, UMLKSK CUI: C0001815
HumanSTAT5A6776signal transducer and activator of transcription 5A
img NCI, Score=801, Pubmed Id: 12842707, UMLKSK CUI: C0001815
HumanSTAT36774signal transducer and activator of transcription 3 (acute-phase response factor)
img GENERIF, Score=1000, Pubmed Id: 16871275, UMLKSK CUI: C0001815
HumanCXCL126387chemokine (C-X-C motif) ligand 12
img GENERIF, Score=1000, Pubmed Id: 18206727, UMLKSK CUI: C0001815
HumanRARB5915retinoic acid receptor, beta
img GENERIF, Score=1000, Pubmed Id: 15361842, UMLKSK CUI: C0001815
HumanPRG25553proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
img GENERIF, Score=1000, Pubmed Id: 19039208, UMLKSK CUI: C0001815
HumanPDGFB5155platelet-derived growth factor beta polypeptide
img GENERIF, Score=1000, Pubmed Id: 17157157, UMLKSK CUI: C0001815
HumanTNFRSF11B4982tumor necrosis factor receptor superfamily, member 11b
img NCI, Score=801, Pubmed Id: 15504545, UMLKSK CUI: C0001815
img NCI, Score=801, Pubmed Id: 15982347, UMLKSK CUI: C0001815
img GENERIF, Score=1000, Pubmed Id: 15504545, UMLKSK CUI: C0001815
HumanNPM14869nucleophosmin (nucleolar phosphoprotein B23, numatrin)
img GENERIF, Score=861, Pubmed Id: 18200037, UMLKSK CUI: C0001815
HumanNOTCH14851notch 1
img NCI, Score=801, Pubmed Id: 16357566, UMLKSK CUI: C0001815
HumanMPL4352myeloproliferative leukemia virus oncogene
img NCI, Score=801, Pubmed Id: 9475764, UMLKSK CUI: C0001815
img NCI, Score=801, Pubmed Id: 11007052, UMLKSK CUI: C0001815
img GENERIF, Score=734, Pubmed Id: 18566540, UMLKSK CUI: C0001815
img GENERIF, Score=734, Pubmed Id: 17507998, UMLKSK CUI: C0001815
img NCI, Score=801, Pubmed Id: 9475764, UMLKSK CUI: C0001815
img NCI, Score=801, Pubmed Id: 15095485, UMLKSK CUI: C0001815
img GENERIF, Score=1000, Pubmed Id: 17408465, UMLKSK CUI: C0001815
img GENERIF, Score=1000, Pubmed Id: 17408398, UMLKSK CUI: C0001815
img NCI, Score=801, Pubmed Id: 8589367, UMLKSK CUI: C0001815
img GENERIF, Score=673, Pubmed Id: 18754026, UMLKSK CUI: C0001815
img GENERIF, Score=1000, Pubmed Id: 17920755, UMLKSK CUI: C0001815
img NCI, Score=801, Pubmed Id: 9864154, UMLKSK CUI: C0001815
HumanMMP144323matrix metallopeptidase 14 (membrane-inserted)
img GENERIF, Score=1000, Pubmed Id: 16877349, UMLKSK CUI: C0001815
HumanMCAM4162melanoma cell adhesion molecule
img GENERIF, Score=1000, Pubmed Id: 19029148, UMLKSK CUI: C0001815
HumanKRT73855keratin 7
img GENERIF, Score=1000, Pubmed Id: 14513050, UMLKSK CUI: C0001815
HumanKIT3815v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
img GENERIF, Score=1000, Pubmed Id: 18165278, UMLKSK CUI: C0001815
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0001815Primary Myelofibrosis0self