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Details
Link-It Detail - Disease - Acute-Phase Reaction
Debug Stats
  • ### Total Build Time: 121 ms 39.377 KB
  • CONCEPT_NAME gt=6 ms Completed: 6 ms rowSize= 338 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 391 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 232 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=4 ms Completed: 4 ms rowSize= 548 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=5 ms Completed: 5 ms rowSize= 1.522 KB
  • CONCEPT_RELATIONSHIPS gt=78 ms Completed: 78 ms rowSize= 12.954 KB
  • CONCEPT_GENES gt=21 ms Completed: 21 ms rowSize= 22.237 KB
  • CONCEPT_XREFS gt=5 ms Completed: 5 ms rowSize= 1.154 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Acute-Phase Reaction C0001349
Definition (1)
An early local inflammatory reaction to insult or injury that consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma.
Semantic Types (2)
Finding (T033)
Pathologic Function (T046)
Parents (1)
img Inflammation C0021368
Ancestral Roots
RootRoot Plus OneDepthParent
img Pathological Conditions, Signs and Symptoms C0039058img Pathologic Processes C00306604img Inflammation C0021368
Relationships (60)

Relation Types:
diso_​to_​anat : 7
diso_​to_​chem : 28
diso_​to_​diso : 17
diso_​to_​phen : 2
diso_​to_​phys : 6


Relationships:
none : 55
consider : 1
isa : 1
part_​of : 2
permuted_​term_​of : 1
Page Size
Current 25
  Page 1 of 3
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANAT87img In Blood C0005768
DISO_to_ANAT73img In Blood C0005768
DISO_to_DISO43img chemically induced C0007994
DISO_to_CHEM30img Acute-Phase Proteins C0001347
DISO_to_PHEN29img genetic aspects C0017399
DISO_to_ANAT26img Liver C0023884
DISO_to_CHEM26img Acute-Phase Proteins C0001347
DISO_to_ANAT22img Liver C0023884
DISO_to_PHEN22img genetic aspects C0017399
DISO_to_CHEM18img Interleukin-6 C0021760
DISO_to_DISO18img chemically induced C0007994
DISO_to_CHEM14img C-Reactive Protein C0006560
DISO_to_CHEM13img C-Reactive Protein C0006560
DISO_to_CHEM13img Interleukin-6 C0021760
DISO_to_CHEM13img Serum Amyloid A Protein C0002723
DISO_to_DISO13img Inflammation C0021368
DISO_to_CHEM12img Cytokines C0079189
DISO_to_CHEM12img Diphosphonates C0012544
DISO_to_CHEM11img Lipopolysaccharides C0023810
DISO_to_CHEM10img Lipopolysaccharides C0023810
DISO_to_PHYS10img Gene Expression Regulation C0017263
DISO_to_CHEM8img Cytokines C0079189
DISO_to_CHEM8img STAT3 Transcription Factor C0253050
DISO_to_CHEM8img Serum Amyloid A Protein C0002723
DISO_to_DISO8img Burns C0006434
Genes (18)

Species:
human : 18
SpeciesGeneGeneIdGene NameEvidence
HumanHAMP57817hepcidin antimicrobial peptide
img GENERIF, Score=884, Pubmed Id: 15725899, UMLKSK CUI: C0001349
HumanIRAK451135interleukin-1 receptor-associated kinase 4
img GENERIF, Score=983, Pubmed Id: 18174872, UMLKSK CUI: C0001349
HumanSOCS39021suppressor of cytokine signaling 3
img GENERIF, Score=1000, Pubmed Id: 12688541, UMLKSK CUI: C0001349
HumanVWF7450von Willebrand factor
img GENERIF, Score=1000, Pubmed Id: 11914659, UMLKSK CUI: C0001349
HumanTNF7124tumor necrosis factor
img GENERIF, Score=1000, Pubmed Id: 18566306, UMLKSK CUI: C0001349
HumanSTAT36774signal transducer and activator of transcription 3 (acute-phase response factor)
img GENERIF, Score=923, Pubmed Id: 16285960, UMLKSK CUI: C0001349
HumanPTX35806pentraxin 3, long
img GENERIF, Score=923, Pubmed Id: 15262177, UMLKSK CUI: C0001349
HumanPPARA5465peroxisome proliferator-activated receptor alpha
img GENERIF, Score=717, Pubmed Id: 14764586, UMLKSK CUI: C0001349
HumanSERPINE15054serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
img GENERIF, Score=1000, Pubmed Id: 15116245, UMLKSK CUI: C0001349
HumanMBL24153mannose-binding lectin (protein C) 2, soluble
img GENERIF, Score=884, Pubmed Id: 17083310, UMLKSK CUI: C0001349
HumanLBP3929lipopolysaccharide binding protein
img GENERIF, Score=923, Pubmed Id: 9338787, UMLKSK CUI: C0001349
HumanIL183606interleukin 18 (interferon-gamma-inducing factor)
img GENERIF, Score=1000, Pubmed Id: 18566306, UMLKSK CUI: C0001349
HumanIL63569interleukin 6 (interferon, beta 2)
img GENERIF, Score=923, Pubmed Id: 16285960, UMLKSK CUI: C0001349
img GENERIF, Score=1000, Pubmed Id: 12900415, UMLKSK CUI: C0001349
img GENERIF, Score=1000, Pubmed Id: 18566306, UMLKSK CUI: C0001349
HumanICAM13383intercellular adhesion molecule 1
img GENERIF, Score=1000, Pubmed Id: 11914659, UMLKSK CUI: C0001349
HumanFOXM12305forkhead box M1
img GENERIF, Score=923, Pubmed Id: 14686788, UMLKSK CUI: C0001349
HumanF122161coagulation factor XII (Hageman factor)
img GENERIF, Score=1000, Pubmed Id: 15567455, UMLKSK CUI: C0001349
HumanCRP1401C-reactive protein, pentraxin-related
img GENERIF, Score=1000, Pubmed Id: 18262272, UMLKSK CUI: C0001349
img GENERIF, Score=923, Pubmed Id: 14634117, UMLKSK CUI: C0001349
HumanCPB21361carboxypeptidase B2 (plasma)
img GENERIF, Score=1000, Pubmed Id: 17473579, UMLKSK CUI: C0001349
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0001349Acute-Phase Reaction0self