Human | HAMP | 57817 | hepcidin antimicrobial peptide | REVIEW: hepcidin as the hormone that links the type II acute phase response to iron handling and erythropoiesis |
Human | IRAK4 | 51135 | interleukin-1 receptor-associated kinase 4 | Two cases of IRAK-4 deficiency that presented with unusual S. aureus infections that were not accompanied by the expected constitutional symptoms or hematologic and acute phase responses are reported |
Human | SOCS3 | 9021 | suppressor of cytokine signaling 3 | SOCS-3 plays an important role in the suppression of cytokine signaling by GH in down-regulating the acute phase response after injury |
Human | VWF | 7450 | von Willebrand factor | raised vWf in breast cancer seems likely to be independent of the acute phase response |
Human | TNF | 7124 | tumor necrosis factor | Inflammatory markers associated with the acute-phase response (IL-6, TNF-alpha, C-reactive protein, and fibrinogen, but not IL-18) are associated with risk of recurrent stroke |
Human | STAT3 | 6774 | signal transducer and activator of transcription 3 (acute-phase response factor) | acetylation-deacetylation reaction as a novel signaling mechanism controlling the IL-6-STAT3 pathway in the hepatic acute phase response |
Human | PTX3 | 5806 | pentraxin 3, long | We provide evidence for expression of PTX3 by vascular smooth muscle cells induced by degraded lipoproteins, which may lead to a vascular acute-phase reaction, contributing to the inflammatory pathogenesis of atherosclerosis |
Human | PPARA | 5465 | peroxisome proliferator-activated receptor alpha | chronic treatment with the PPARalpha agonist fully prevents the acute phase response gene expression in wild-type but not in PPARalpha-deficient mice |
Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | REVIEW of factors which influence PAI-1 levels and the possible role of PAI-1 polymorphisms in the acute phase response and cardiovascular diseases |
Human | MBL2 | 4153 | mannose-binding lectin (protein C) 2, soluble | The nature and expression of MBL deficiency during a surgery-induced acute-phase response is reported |
Human | LBP | 3929 | lipopolysaccharide binding protein | mouse study showing that LBP is required for rapid acute-phase response to LPS but not for clearance of LPS from circulation |
Human | IL18 | 3606 | interleukin 18 (interferon-gamma-inducing factor) | Inflammatory markers associated with the acute-phase response (IL-6, TNF-alpha, C-reactive protein, and fibrinogen, but not IL-18) are associated with risk of recurrent stroke |
Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | Inflammatory markers associated with the acute-phase response (IL-6, TNF-alpha, C-reactive protein, and fibrinogen, but not IL-18) are associated with risk of recurrent stroke acetylation-deacetylation reaction as a novel signaling mechanism controlling the IL-6-STAT3 pathway in the hepatic acute phase response IL-6 response elements have roles in transactivating Stat3 on fibrinogen promoters with additional transcription factors during acute phase response |
Human | ICAM1 | 3383 | intercellular adhesion molecule 1 | raised sICAM-1 in breast cancer, like the acute phase response, reflects inflammation |
Human | FOXM1 | 2305 | forkhead box M1 | hepatocyte nuclear translocation of the FoxM1B transgene protein was rapidly induced during the hepatic acute phase response |
Human | F12 | 2161 | coagulation factor XII (Hageman factor) | similar FXIIa levels in acute or chronic phases of coronary atherosclerosis suggests that the initial arterial denudation and acute-phase response associated to acute coronary syndromes are not major determinants for prolonged FXII activation |
Human | CRP | 1401 | C-reactive protein, pentraxin-related | Protection against lethality is conferred neither by an autologous acute-phase response to sterile inflammatory stimuli given wild-type mice 24 h before lipopolysaccharide challenge, nor by human CRP, passively administered or expressed transgenically findings show that IL-1beta NFkappakappaB- & C/EBPbeta-dependently induces IL-6-synthesis in hepatocytes; IL-6 consecutively stimulates CRP production; this mechanism may be crucial for acute phase response in general & CRP production in particular |
Human | CPB2 | 1361 | carboxypeptidase B2 (plasma) | elevated TAFI antigen levels may be a consequence of an acute phase reaction, and together with a depressed overall fibrinolysis potential suggest impaired fibrinolysis in patients with acute ischemic stroke |