Human | CCR2 | 729230 | chemokine (C-C motif) receptor 2 | Click here to display 25 evidence detail records. |
Human | APOBEC3H | 164668 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H | the anti-HIV activity of APOBEC3H seems to be regulated by a combination of genomic variation and alternative splicing |
Human | APOBEC3G | 60489 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | investigation of possible anti-HIV activity of hA3G (APOBEC3G); hA3G mRNA levels follow a hierarchical order of long-term nonprogressors>HIV-uninfected>Progressors; hA3G mRNA abundance correlates with surrogates of HIV disease progression Title:APOBEC3G genetic variants and their influence on the progression to AIDS.|Association:Y|Conclusion:These studies suggest that there may be a modifying role of variants of APOBEC3G on HIV-1 disease progression that warrants further investigation. diverse A3G oligomerization modes contribute to the human immunodeficiency virus, type 1, proviral DNA mutational bias |
Human | WFDC1 | 58189 | WAP four-disulfide core domain 1 | ps20 promoted HIV entry via fusion and augmented CD54 integrin expression |
Human | RETN | 56729 | resistin | Among HIV-infected subjects with insulin resistance and lipoatrophy, resistin levels decreased significantly after rosiglitazone |
Human | TLR9 | 54106 | toll-like receptor 9 | Costimulation with TLR9 (or TLR2) and TLR4 induces synergistic release of Th1 cytokines, IFN-gamma and TNF-alpha, and additive HIV-LTR trans-activation and HIV replication, as measured by p24 antigen release from HIV-1 transgenic mouse spleen cells B cells from HIV-infected persons express reduced levels of TLR9 mRNA, and this defect is especially pronounced among memory B cells |
Human | CPSF3 | 51692 | cleavage and polyadenylation specific factor 3, 73kDa | up-regulated by HIV-1 TAT protein; this could represent a novel mechanism by which HIV increases mRNA processing, causing an increase in both cell and viral gene expression |
Human | CD209 | 30835 | CD209 molecule | Click here to display 8 evidence detail records. |
Human | CD274 | 29126 | CD274 molecule | findings show monocytes & CCR5(+) T cells of HIV-uninfected donors upregulate PDL-1 on in vitro exposure to HIV; HIV-induced PDL-1 required interferon alpha; in setting of HIV infection, IFN-alpha may negatively affect T cell responses by inducing PDL-1 up-regulation in HIV infection, relation to disease progression, and possible role in AIDS progression |
Human | APOBEC3C | 27350 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C | reviews the current knowledge on the mechanism of APOBEC3-dependent retrovirus restriction and discuss whether this innate host-defense system actively contributes to HIV genetic variation Study compared the antiviral activities of human and murine Apobec3 (A3), and found that, HIV is able to resist human A3G but is sensitive to murine A3, whereas murine leukemia virus is relatively resistant to murine A3 but sensitive to human A3G |
Human | BBC3 | 27113 | BCL2 binding component 3 | In the absence of PUMA, there is no HIV apoptosis |
Human | PABPC1 | 26986 | poly(A) binding protein, cytoplasmic 1 | The authors demonstrate that inhibition of HIV expression by Sam68DeltaC is correlated with a loss of PABP1 binding with no attendant change in polyadenosine tail length of the affected RNAs |
Human | AIPL1 | 23746 | aryl hydrocarbon receptor interacting protein-like 1 | Interacts with and aids in processing of farnesylated proteins in the retina |
Human | BRD4 | 23476 | bromodomain containing 4 | Overexpression of the BRD4 P-TEFb-interacting domain disrupts the interaction between the HIV transactivator Tat and positive transcription elongation factor b and suppresses the ability of Tat to transactivate the HIV promoter |
Human | SIRT1 | 23411 | sirtuin 1 | Hiv Tat is deacetylated by human sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent class III protein deacetylase in vitro and in vivo |
Human | DICER1 | 23405 | dicer 1, ribonuclease type III | These results suggest that, in the context of HIV replication, TRBP contributes mainly to the enhancement of virus production and that Dicer does not mediate HIV restriction by RNAi |
Human | PSIP1 | 11168 | PC4 and SFRS1 interacting protein 1 | LEDGF is thus the first example of a cellular protein controlling the location of HIV integration in human cells data validate LEDGF/p75 as an important cellular cofactor for HIV integration The complementary inhibition by LEDGF/p75 knockdown and mutagenesis at the integrase-LEDGF/p75 interface points to the incapability of HIV to circumvent LEDGF/p75 function during proviral integration |
Human | CXCR6 | 10663 | chemokine (C-X-C motif) receptor 6 | There is an association between CXCR6 genotype and progression from Pneumocystis carinii pneumonia to death in African-Americans with AIDS |
Human | KHDRBS1 | 10657 | KH domain containing, RNA binding, signal transduction associated 1 | Sam68 is involved in Rev-mediated RNA export and is required for HIV production |
Human | HEXIM1 | 10614 | hexamethylene bis-acetamide inducible 1 | Binding of HEXIM1 is a prerequisite for association of P-TEFb with the G302-C324 apical region of the 3' hairpin of 7SK that is highly reminiscent of the human immunodeficiency virus transactivation-responsive RNA |
Human | CLEC4M | 10332 | C-type lectin domain family 4, member M | Title:Polymorphisms and haplotypes of the CD209L gene and their association with the clinical courses of HIV-positive Japanese patients.|Association:Not Found|Conclusion:Among HIV-infected patients, the A allele in intron 5 at IMS-JST025124 was associated with the higher number of lowest CD4+ cell counts during the whole clinical course. In 44 patients, whose CD4+ cells were counted on more than three occassions before the start of anti-retroviral treatment, this A allele was again associated with the higher number of the lowest CD4 cell counts during untreated periods. Title:Polymorphisms and haplotypes of the CD209L gene and their association with the clinical courses of HIV-positive Japanese patients.|Association:Not Found|Conclusion:Not Found |
Human | KLRG1 | 10219 | killer cell lectin-like receptor subfamily G, member 1 | virus-specific CD8+ T cells are mostly KLRG1+ in chronic viral infections (human immunodeficiency virus, cytomegalovirus, and Epstein-Barr virus) but not in resolved infection (influenza virus) |
Human | FGFBP1 | 9982 | fibroblast growth factor binding protein 1 | The upregulation of FGF-BP by regenerating renal tubular epithelial cells may provide a mechanism by which the regenerative and angiogenic activity of FGF-2 in renal capillaries can be modulated in children with HIV-HUS and other renal disease |
Human | MRC2 | 9902 | mannose receptor, C type 2 | Approximately 60% of the initial association of HIV with macrophages that lack expression of DC-SIGN (a dendritic cell-specific ICAM-3 receptor/HIV-1-binding protein) is mediated by the macrophage mannose receptor |
Human | NMT2 | 9397 | N-myristoyltransferase 2 | Nef is preferentially myristoylated by NMT2, suggesting that selective inhibition of NMT2 may provide a novel means of blocking HIV virulence |