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Details
Link-It Detail - Anatomy - Allogeneic CD4+ Memory Th1-like T Cells/Microparticle-bound Anti-CD3/anti-CD28
Debug Stats
  • ### Total Build Time: 28 ms 4.488 KB
  • CONCEPT_NAME gt=5 ms Completed: 5 ms rowSize= 454 bytes
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Anatomy (1)
Allogeneic CD4+ Memory Th1-like T Cells/Microparticle-bound Anti-CD3/anti-CD28 C2348423
Definition (1)
A preparation consisting of allogeneic, differentiated Th1-like T cells bound to T cell-stimulating monoclonal antibodies with potential antitumor activity. More specifically, allogeneic CD4+ memory Th1-like T cells/microparticle-bound anti-CD3/anti-CD28 are composed of a proprietary preparation of mismatched, allogeneic differentiated CD4+ memory Th1-like T cells bound to paramagnetic, epoxy-covered 4.5 micron microparticles with covalently bound anti-CD3/anti-CD28 monoclonal antibodies at a 2:1 bead:cell ratio. The CD4+ memory Th1-like T cells are derived from precursors found in the circulation of a normal donor. Stimulated by the microparticle-bound monoclonal antibodies, the infused T cells produce pro-inflammatory, anti-tumor cytokines such as like IFN-gamma, TNF-beta, and IL-2, disabling tumor immune avoidance mechanisms and stimulating the host immune system to both reject the infused T cells and kill tumor cells.
Relationships (2)

Relation Types:
anat_​to_​anat : 1
anat_​to_​chem : 1


Relationships:
tradename_​of : 2
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
ANAT_to_ANATtradename_ofimg AlloStim C2825117
ANAT_to_CHEMtradename_ofimg AlloStim C2825117
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C2348423Allogeneic CD4+ Memory Th1-like T Cells/Microparticle-bound Anti-CD3/anti-CD280self