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Details
Link-It Detail - Anatomy - EGFRBi-Armed Autologous T Cells
Debug Stats
  • ### Total Build Time: 23 ms 4.485 KB
  • CONCEPT_NAME gt=7 ms Completed: 7 ms rowSize= 360 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 724 bytes
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  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
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  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
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  • CONCEPT_XREFS gt=6 ms Completed: 6 ms rowSize= 1.165 KB
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Anatomy (1)
EGFRBi-Armed Autologous T Cells C2348359
Definition (1)
Autologous activated T cells, loaded with a bispecific antibody produced by heteroconjugation of anti-CD3 and anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, with potential antineoplastic activity. Binding of EGFRBi-armed autologous activated T cells to EGFR-positive tumor cells may result in increased T cell-mediated cytotoxicity towards tumor cells expressing EGFR. Arming activated T cells with this bispecific antibody may significantly increase T cell secretion of anti-tumor associated cytokines such as IL2, RANTES, IFN-gamma, and TNF-alpha.
Relationships (2)

Relation Types:
anat_​to_​anat : 1
anat_​to_​phys : 1


Relationships:
cell_​type_​or_​tissue_​affected_​by_​chemical_​or_​drug : 1
is_​mechanism_​of_​action_​of_​chemical_​or_​drug : 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
ANAT_to_ANATcell_type_or_tissue_affected_by_chemical_or_drugimg Cytotoxic T-Lymphocytes C0039195
ANAT_to_PHYSis_mechanism_of_action_of_chemical_or_drugimg Antigen Sensitization C1706823
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C2348359EGFRBi-Armed Autologous T Cells0self