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Details
Link-It Detail - Anatomy - Autologous LMP1-/LMP2- Specific Cytotoxic T-Lymphocytes
Debug Stats
  • ### Total Build Time: 12 ms 6.042 KB
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Anatomy (1)
Autologous LMP1-/LMP2- Specific Cytotoxic T-Lymphocytes C2346885
Definition (1)
A preparation of cytotoxic T-lymphocytes (CTL), specifically reactive to the Epstein-Barr virus (EBV) latent membrane proteins (LMP) 1 and 2, with potential antineoplastic activity. Autologous dendritic cells and EBV-infected lymphoblastoid cell lines (LCL) from patients with EBV-positive nasopharyngeal carcinoma (NPC) are transduced with an LMP1/LMP2-expressing adenoviral vector, are irradiated, and then are used to stimulate and expand autologous CTL to produce autologous LMP1-/LMP2-specific CTL ex vivo. Administration of autologous LMP1-/LMP2- specific cytotoxic T-lymphocytes may result in a specific CTL response against tumor cells expressing LMP1 and LMP2, resulting in cell lysis and inhibition of tumor cell proliferation in vivo. Among a limited set of viral antigens expressed by NPC cells, LMP1 and LMP2 are weak immunogens which, nevertheless, are capable of inducing a T-lymphocyte response.
Relationships (4)

Relation Types:
anat_​to_​anat : 1
anat_​to_​phys : 1
chem_​to_​anat : 1
chem_​to_​phys : 1


Relationships:
cell_​type_​or_​tissue_​affected_​by_​chemical_​or_​drug : 2
is_​mechanism_​of_​action_​of_​chemical_​or_​drug : 2
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
ANAT_to_ANATcell_type_or_tissue_affected_by_chemical_or_drugimg Cytotoxic T-Lymphocytes C0039195
ANAT_to_PHYSis_mechanism_of_action_of_chemical_or_drugimg Antigen Sensitization C1706823
CHEM_to_ANATcell_type_or_tissue_affected_by_chemical_or_drugimg Cytotoxic T-Lymphocytes C0039195
CHEM_to_PHYSis_mechanism_of_action_of_chemical_or_drugimg Antigen Sensitization C1706823
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C2346885Autologous LMP1-/LMP2- Specific Cytotoxic T-Lymphocytes0self