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Details
Link-It Detail - Anatomy - Apoptosomes
Debug Stats
  • ### Total Build Time: 22 ms 7.461 KB
  • CONCEPT_NAME gt=4 ms Completed: 4 ms rowSize= 320 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 574 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 266 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=4 ms Completed: 4 ms rowSize= 553 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.502 KB
  • CONCEPT_RELATIONSHIPS gt=9 ms Completed: 9 ms rowSize= 3.062 KB
  • CONCEPT_GENES gt=1 ms Completed: 1 ms rowSize= 45 bytes
  • CONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.146 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Anatomy (1)
Apoptosomes C1657248
Definition (1)
Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.
Semantic Types (2)
Amino Acid, Peptide, or Protein (T116)
Biologically Active Substance (T123)
Parents (1)
img cytosol component C1820051
Ancestral Roots
RootRoot Plus OneDepthParent
img intracellular part C1820033img cytoplasm component C18200504img cytosol component C1820051
Relationships (5)

Relation Types:
anat_​to_​anat : 1
anat_​to_​chem : 3
anat_​to_​phys : 1


Relationships:
none : 4
permuted_​term_​of : 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
ANAT_to_PHYS20img Apoptosis C0162638
ANAT_to_CHEM12img Apoptotic Protease-Activating Factor 1 C0664613
ANAT_to_CHEM12img Caspase 9 C0910167
ANAT_to_CHEM6img Caspase 3 C0291573
ANAT_to_ANATpermuted_term_ofimg Apoptosomal Protein Complex C1657248
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C1657248Apoptosomes0self