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Details
Link-It Detail - Jax Mouse Phenotype - abnormal kidney collecting duct principal cell morphology
Debug Stats
  • ### Total Build Time: 30 ms 6.943 KB
  • CONCEPT_NAME gt=17 ms Completed: 17 ms rowSize= 442 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
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  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=4 ms Completed: 4 ms rowSize= 608 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
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  • CONCEPT_RELATIONSHIPS gt=0 Completed: 0 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=4 ms Completed: 4 ms rowSize= 2.288 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.194 KB
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Jax Mouse Phenotype (1)
abnormal kidney collecting duct principal cell morphology MP:0011757
Definition (1)
any structural abnormality of the cuboidal epithelial cells found in the collecting ducts of the kidney which regulate sodium and potassium balance via channels located on the cells apical membrane. Aldosterone increases the number of Na+/K+-ATPase pumps that allow increased sodium reabsorption and potassium secretion whereas antidiuretic hormone (vasopressin) determines the expression of aquaporin channels on the cell surface; together, aldosterone and vasopressin let the principal cell control the quantity of water that is reabsorbed
Parents (1)
img abnormal kidney collecting duct epithelium morphology MP:0011843
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img renal/urinary system phenotype MP:00053677img abnormal kidney collecting duct epithelium morphology MP:0011843
Genes (1)

Species:
human : 1
SpeciesGeneGeneIdGene NameEvidence
HumanCD63967CD63 molecule
img Jax MP, Pubmed Id: 19075008, MOUSE PHENOTYPE ID: MGI:99529
img Jax MP, Pubmed Id: 8430831, MOUSE PHENOTYPE ID: MGI:97446
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0011757abnormal kidney collecting duct principal cell morphology0self