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Details
Link-It Detail - Jax Mouse Phenotype - abnormal solitary pulmonary neuroendocrine cell morphology
Debug Stats
  • ### Total Build Time: 73 ms 12.059 KB
  • CONCEPT_NAME gt=5 ms Completed: 5 ms rowSize= 444 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 722 bytes
  • CONCEPT_SYNONYM gt=0 Completed: 0 ms rowSize= 172 bytes
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  • CONCEPT_PARENTS gt=18 ms Completed: 18 ms rowSize= 594 bytes
  • CONCEPT_CHILDREN gt=10 ms Completed: 10 ms rowSize= 1.551 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=16 ms Completed: 16 ms rowSize= 2.945 KB
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=18 ms Completed: 18 ms rowSize= 4.336 KB
  • CONCEPT_XREFS gt=4 ms Completed: 4 ms rowSize= 1.195 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
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Jax Mouse Phenotype (1)
abnormal solitary pulmonary neuroendocrine cell morphology MP:0010914
Definition (1)
any structural anomaly of the specialized non-ciliated, round- to oval-shaped epithelial cells found as solitary cells in the nasal respiratory epithelium and the mucosa of the larynx, trachea and bronchi up to the terminal bronchioles; PNECs are the first cell type to differentiate during early fetal lung development, produce amine (e.g. serotonin, 5-HT) and peptides (e.g. bombesin, calcitonin) with growth factor-like properties, and appear to be involved in processes ranging from lung development and respiratory physiology to repair, disease and carcinogenesis
Synonyms (1)
"abnormal PNECs" EXACT
Parents (1)
img abnormal neuroendocrine cell morphology MP:0010913
Children (3)
img absent solitary pulmonary neuroendocrine cells MP:0010917
img increased solitary pulmonary neuroendocrine cell number MP:0010915
img decreased solitary pulmonary neuroendocrine cell number MP:0010916
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img nervous system phenotype MP:00036316img abnormal neuroendocrine cell morphology MP:0010913
img mammalian phenotype MP:0000001img endocrine/exocrine gland phenotype MP:00053796img abnormal neuroendocrine cell morphology MP:0010913
Genes (7)

Species:
human : 7
SpeciesGeneGeneIdGene NameEvidence
HumanPOFUT123509protein O-fucosyltransferase 1
INFERRED
HumanPTEN5728phosphatase and tensin homolog
INFERRED
HumanNEUROD14760neuronal differentiation 1
INFERRED
HumanHES13280hairy and enhancer of split 1, (Drosophila)
INFERRED
HumanFBN12200fibrillin 1
INFERRED
HumanCRH1392corticotropin releasing hormone
img Jax MP, Pubmed Id: 9922208, MOUSE PHENOTYPE ID: MGI:88496
HumanASCL1429achaete-scute complex homolog 1 (Drosophila)
INFERRED
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0010914abnormal solitary pulmonary neuroendocrine cell morphology0self