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Details
Link-It Detail - Jax Mouse Phenotype - decreased type II pneumocyte number
Debug Stats
  • ### Total Build Time: 16 ms 49.993 KB
  • CONCEPT_NAME gt=2 ms Completed: 2 ms rowSize= 398 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 650 bytes
  • CONCEPT_SYNONYM gt=0 Completed: 0 ms rowSize= 196 bytes
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  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
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  • CONCEPT_PARENTS gt=3 ms Completed: 3 ms rowSize= 593 bytes
  • CONCEPT_CHILDREN gt=2 ms Completed: 2 ms rowSize= 583 bytes
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  • CONCEPT_RELATIONSHIPS gt=0 Completed: 0 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=8 ms Completed: 8 ms rowSize= 43.370 KB
  • CONCEPT_XREFS gt=0 Completed: 0 ms rowSize= 1.173 KB
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Jax Mouse Phenotype (1)
decreased type II pneumocyte number MP:0010811
Definition (1)
reduced number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored
Synonyms (1)
"decreased Cuboidal type II cell number" EXACT
Parents (1)
img abnormal type II pneumocyte morphology MP:0002275
Children (1)
img absent type II pneumocytes MP:0010812
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img respiratory system phenotype MP:000538811img abnormal type II pneumocyte morphology MP:0002275
img mammalian phenotype MP:0000001img respiratory system phenotype MP:00053889img abnormal type II pneumocyte morphology MP:0002275
Genes (7)

Species:
human : 7
SpeciesGeneGeneIdGene NameEvidence
HumanPTGES310728prostaglandin E synthase 3 (cytosolic)
img Jax MP, Pubmed Id: 12053176, MOUSE PHENOTYPE ID: MGI:109169
img Jax MP, Pubmed Id: 15716345, MOUSE PHENOTYPE ID: MGI:3574944
img Jax MP, Pubmed Id: 17130238, MOUSE PHENOTYPE ID: MGI:2679530
img Jax MP, Pubmed Id: 15716345, MOUSE PHENOTYPE ID: MGI:3574944
img Jax MP, Pubmed Id: 16414041, MOUSE PHENOTYPE ID: MGI:1338938
img Jax MP, Pubmed Id: 17000766, MOUSE PHENOTYPE ID: MGI:1929282
img Jax MP, Pubmed Id: 7493022
img Jax MP, Pubmed Id: 14702106, MOUSE PHENOTYPE ID: MGI:103038
img Jax MP, Pubmed Id: 10600892
img Jax MP, Pubmed Id: 15936333, MOUSE PHENOTYPE ID: MGI:105382
img Jax MP, Pubmed Id: 17000766, MOUSE PHENOTYPE ID: MGI:1929282
HumanNKX2-17080
INFERRED
HumanTCF216943transcription factor 21
INFERRED
HumanSTAT36774signal transducer and activator of transcription 3 (acute-phase response factor)
img Jax MP, Pubmed Id: 12053176, MOUSE PHENOTYPE ID: MGI:109169
img Jax MP, Pubmed Id: 15936333, MOUSE PHENOTYPE ID: MGI:105382
img Jax MP, Pubmed Id: 15716345, MOUSE PHENOTYPE ID: MGI:3574944
img Jax MP, Pubmed Id: 7493022
img Jax MP, Pubmed Id: 15716345, MOUSE PHENOTYPE ID: MGI:3574944
img Jax MP, Pubmed Id: 16414041, MOUSE PHENOTYPE ID: MGI:1338938
img Jax MP, Pubmed Id: 14702106, MOUSE PHENOTYPE ID: MGI:103038
img Jax MP, Pubmed Id: 17130238, MOUSE PHENOTYPE ID: MGI:2679530
img Jax MP, Pubmed Id: 10600892
img Jax MP, Pubmed Id: 17000766, MOUSE PHENOTYPE ID: MGI:1929282
img Jax MP, Pubmed Id: 17000766, MOUSE PHENOTYPE ID: MGI:1929282
HumanLAMA53911laminin, alpha 5
img Jax MP, Pubmed Id: 17000766, MOUSE PHENOTYPE ID: MGI:1929282
img Jax MP, Pubmed Id: 17000766, MOUSE PHENOTYPE ID: MGI:1929282
img Jax MP, Pubmed Id: 16414041, MOUSE PHENOTYPE ID: MGI:1338938
img Jax MP, Pubmed Id: 10600892
img Jax MP, Pubmed Id: 12053176, MOUSE PHENOTYPE ID: MGI:109169
img Jax MP, Pubmed Id: 14702106, MOUSE PHENOTYPE ID: MGI:103038
img Jax MP, Pubmed Id: 15936333, MOUSE PHENOTYPE ID: MGI:105382
img Jax MP, Pubmed Id: 15716345, MOUSE PHENOTYPE ID: MGI:3574944
img Jax MP, Pubmed Id: 17130238, MOUSE PHENOTYPE ID: MGI:2679530
img Jax MP, Pubmed Id: 15716345, MOUSE PHENOTYPE ID: MGI:3574944
img Jax MP, Pubmed Id: 7493022
HumanEPAS12034endothelial PAS domain protein 1
img Jax MP, Pubmed Id: 17130238, MOUSE PHENOTYPE ID: MGI:2679530
img Jax MP, Pubmed Id: 15716345, MOUSE PHENOTYPE ID: MGI:3574944
img Jax MP, Pubmed Id: 10600892
img Jax MP, Pubmed Id: 15936333, MOUSE PHENOTYPE ID: MGI:105382
img Jax MP, Pubmed Id: 17000766, MOUSE PHENOTYPE ID: MGI:1929282
img Jax MP, Pubmed Id: 12053176, MOUSE PHENOTYPE ID: MGI:109169
img Jax MP, Pubmed Id: 15716345, MOUSE PHENOTYPE ID: MGI:3574944
img Jax MP, Pubmed Id: 17000766, MOUSE PHENOTYPE ID: MGI:1929282
img Jax MP, Pubmed Id: 7493022
img Jax MP, Pubmed Id: 16414041, MOUSE PHENOTYPE ID: MGI:1338938
img Jax MP, Pubmed Id: 14702106, MOUSE PHENOTYPE ID: MGI:103038
HumanBMPR1A657bone morphogenetic protein receptor, type IA
img Jax MP, Pubmed Id: 16414041, MOUSE PHENOTYPE ID: MGI:1338938
img Jax MP, Pubmed Id: 10600892
img Jax MP, Pubmed Id: 15716345, MOUSE PHENOTYPE ID: MGI:3574944
img Jax MP, Pubmed Id: 7493022
img Jax MP, Pubmed Id: 15716345, MOUSE PHENOTYPE ID: MGI:3574944
img Jax MP, Pubmed Id: 17130238, MOUSE PHENOTYPE ID: MGI:2679530
img Jax MP, Pubmed Id: 12053176, MOUSE PHENOTYPE ID: MGI:109169
img Jax MP, Pubmed Id: 15936333, MOUSE PHENOTYPE ID: MGI:105382
img Jax MP, Pubmed Id: 14702106, MOUSE PHENOTYPE ID: MGI:103038
img Jax MP, Pubmed Id: 17000766, MOUSE PHENOTYPE ID: MGI:1929282
img Jax MP, Pubmed Id: 17000766, MOUSE PHENOTYPE ID: MGI:1929282
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0010811decreased type II pneumocyte number0self