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Details
Link-It Detail - Jax Mouse Phenotype - abnormal Sertoli cell phagocytosis
Debug Stats
  • ### Total Build Time: 76 ms 9.336 KB
  • CONCEPT_NAME gt=8 ms Completed: 8 ms rowSize= 396 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 554 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=11 ms Completed: 11 ms rowSize= 578 bytes
  • CONCEPT_CHILDREN gt=9 ms Completed: 9 ms rowSize= 1.039 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=18 ms Completed: 18 ms rowSize= 1.574 KB
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=23 ms Completed: 23 ms rowSize= 3.914 KB
  • CONCEPT_XREFS gt=4 ms Completed: 4 ms rowSize= 1.172 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
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Jax Mouse Phenotype (1)
abnormal Sertoli cell phagocytosis MP:0009851
Definition (1)
altered ability of the Sertoli cells to endocytose and degrade the apoptotic spermatogenic cells and residual bodies (shed cytoplasts) during the maturation phase of spermiogenesis; normally, greater than 50 per cent of differentiating spermatogenic cells undergo apoptosis before maturing into spermatozoa, and these cells are selectively and rapidly eliminated through phagocytosis by Sertoli cells
Parents (1)
img abnormal spermiogenesis MP:0001932
Children (2)
img decreased Sertoli cell phagocytosis MP:0009853
img increased Sertoli cell phagocytosis MP:0009852
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img reproductive system phenotype MP:00053897img abnormal spermiogenesis MP:0001932
Genes (6)

Species:
human : 6
SpeciesGeneGeneIdGene NameEvidence
HumanEHD110938EH-domain containing 1
img Jax MP, Pubmed Id: 20359371, MOUSE PHENOTYPE ID: MGI:1341878
HumanMERTK10461c-mer proto-oncogene tyrosine kinase
INFERRED
HumanKATNB110300katanin p80 (WD repeat containing) subunit B 1
INFERRED
HumanELMO19844engulfment and cell motility 1
INFERRED
HumanTYRO37301TYRO3 protein tyrosine kinase
INFERRED
HumanAXL558AXL receptor tyrosine kinase
INFERRED
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0009851abnormal Sertoli cell phagocytosis0self