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Details
Link-It Detail - Jax Mouse Phenotype - abnormal interleukin-1 beta secretion
Debug Stats
  • ### Total Build Time: 26 ms 19.869 KB
  • CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 402 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
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  • CONCEPT_SYNONYM gt=0 Completed: 0 ms rowSize= 181 bytes
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  • CONCEPT_GENES gt=13 ms Completed: 13 ms rowSize= 14.338 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.175 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Jax Mouse Phenotype (1)
abnormal interleukin-1 beta secretion MP:0008656
Definition (1)
anomaly in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane
Synonyms (1)
"abnormal Il1b secretion" EXACT
Parents (1)
img abnormal interleukin-1 secretion MP:0008650
Children (2)
img decreased interleukin-1 beta secretion MP:0008658
img increased interleukin-1 beta secretion MP:0008657
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img immune system phenotype MP:00053878img abnormal interleukin-1 secretion MP:0008650
Genes (59)

Species:
human : 59
Page Size
Current 25
  Page 1 of 3
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Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanCASP12100506742caspase 12 (gene/pseudogene)
INFERRED
HumanCD300LF146722CD300 molecule-like family member f
INFERRED
HumanCD200R1131450CD200 receptor 1
INFERRED
HumanGBP5115362guanylate binding protein 5
INFERRED
HumanNLRP3114548NLR family, pyrin domain containing 3
INFERRED
HumanIL3390865interleukin 33
INFERRED
HumanZC3H12A80149zinc finger CCCH-type containing 12A
INFERRED
HumanNLRX179671NLR family member X1
INFERRED
HumanTNFAIP8L279626tumor necrosis factor, alpha-induced protein 8-like 2
INFERRED
HumanPINK165018PTEN induced putative kinase 1
INFERRED
HumanNOD264127nucleotide-binding oligomerization domain containing 2
INFERRED
HumanNLRC458484NLR family, CARD domain containing 4
INFERRED
HumanATG16L155054autophagy related 16-like 1 (S. cerevisiae)
INFERRED
HumanTREM154210triggering receptor expressed on myeloid cells 1
INFERRED
HumanPILRB29990paired immunoglobin-like type 2 receptor beta
INFERRED
HumanPYCARD29108PYD and CARD domain containing
INFERRED
HumanNLRP122861NLR family, pyrin domain containing 1
INFERRED
HumanMAP4K111184mitogen-activated protein kinase kinase kinase kinase 1
INFERRED
HumanB3GNT210678UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
INFERRED
HumanAIM29447absent in melanoma 2
INFERRED
HumanMAPKAPK29261mitogen-activated protein kinase-activated protein kinase 2
INFERRED
HumanTAX1BP18887Tax1 (human T-cell leukemia virus type I) binding protein 1
INFERRED
HumanSOCS28835suppressor of cytokine signaling 2
INFERRED
HumanMBTPS18720membrane-bound transcription factor peptidase, site 1
INFERRED
HumanNCOA38202nuclear receptor coactivator 3
INFERRED
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0008656abnormal interleukin-1 beta secretion0self