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Details
Link-It Detail - Jax Mouse Phenotype - abnormal tumor necrosis factor secretion
Debug Stats
  • ### Total Build Time: 81 ms 20.879 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 408 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 511 bytes
  • CONCEPT_SYNONYM gt=0 Completed: 0 ms rowSize= 181 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=5 ms Completed: 5 ms rowSize= 582 bytes
  • CONCEPT_CHILDREN gt=3 ms Completed: 3 ms rowSize= 1.051 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=3 ms Completed: 3 ms rowSize= 1.572 KB
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=60 ms Completed: 60 ms rowSize= 15.291 KB
  • CONCEPT_XREFS gt=4 ms Completed: 4 ms rowSize= 1.178 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Jax Mouse Phenotype (1)
abnormal tumor necrosis factor secretion MP:0008556
Definition (1)
anomaly in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
Synonyms (1)
"abnormal TNFA secretion" EXACT
Parents (1)
img abnormal cytokine secretion MP:0003009
Children (2)
img increased tumor necrosis factor secretion MP:0008560
img decreased tumor necrosis factor secretion MP:0008561
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img immune system phenotype MP:00053876img abnormal cytokine secretion MP:0003009
Genes (170)

Species:
human : 170
Page Size
Current 25
  Page 1 of 7
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Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanGIMAP1-GIMAP5100527949
INFERRED
HumanCCR2729230chemokine (C-C motif) receptor 2
INFERRED
HumanTREML1340205triggering receptor expressed on myeloid cells-like 1
INFERRED
HumanNLRC3197358NLR family, CARD domain containing 3
INFERRED
HumanB3GNT6192134UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)
INFERRED
HumanTICAM1148022toll-like receptor adaptor molecule 1
INFERRED
HumanCD200R1131450CD200 receptor 1
INFERRED
HumanSLC15A4121260solute carrier family 15 (oligopeptide transporter), member 4
INFERRED
HumanCLEC6A93978C-type lectin domain family 6, member A
INFERRED
HumanTIMD491937T-cell immunoglobulin and mucin domain containing 4
INFERRED
HumanUNC93B181622unc-93 homolog B1 (C. elegans)
Click here to display 7 evidence detail records.
HumanZC3H12A80149zinc finger CCCH-type containing 12A
INFERRED
HumanRHBDF279651rhomboid 5 homolog 2 (Drosophila)
INFERRED
HumanTNFAIP8L279626tumor necrosis factor, alpha-induced protein 8-like 2
INFERRED
HumanMMP2879148matrix metallopeptidase 28
INFERRED
HumanDHX5879132DEXH (Asp-Glu-X-His) box polypeptide 58
INFERRED
HumanNFKBIZ64332nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Click here to display 7 evidence detail records.
HumanCARD964170caspase recruitment domain family, member 9
INFERRED
HumanNOD264127nucleotide-binding oligomerization domain containing 2
INFERRED
HumanSELK58515selenoprotein K
INFERRED
HumanCCAR257805cell cycle and apoptosis regulator 2
INFERRED
HumanMAVS57506mitochondrial antiviral signaling protein
INFERRED
HumanPELI157162pellino E3 ubiquitin protein ligase 1
INFERRED
HumanPBK55872PDZ binding kinase
INFERRED
HumanUACA55075uveal autoantigen with coiled-coil domains and ankyrin repeats
INFERRED
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0008556abnormal tumor necrosis factor secretion0self