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Details
Link-It Detail - Jax Mouse Phenotype - increased cellular sensitivity to alkylating agents
Debug Stats
  • ### Total Build Time: 66 ms 30.778 KB
  • CONCEPT_NAME gt=4 ms Completed: 4 ms rowSize= 430 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 236 bytes
  • CONCEPT_SYNONYM gt=0 Completed: 0 ms rowSize= 208 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=13 ms Completed: 13 ms rowSize= 598 bytes
  • CONCEPT_CHILDREN gt=15 ms Completed: 15 ms rowSize= 1.545 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.583 KB
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=28 ms Completed: 28 ms rowSize= 24.880 KB
  • CONCEPT_XREFS gt=4 ms Completed: 4 ms rowSize= 1.188 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Jax Mouse Phenotype (1)
increased cellular sensitivity to alkylating agents MP:0008402
Definition (1)
greater incidence of cell death following exposure to agents that cause DNA damage
Synonyms (1)
"decreased cellular resistance to alkylating agents" EXACT
Parents (1)
img increased sensitivity to induced cell death MP:0008943
Children (3)
img increased cellular sensitivity to thiophosphamide MP:0009876
img increased cellular sensitivity to hydroxyurea MP:0008409
img increased cellular sensitivity to methylmethanesulfonate MP:0008404
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img cellular phenotype MP:00053847img increased sensitivity to induced cell death MP:0008943
Genes (13)

Species:
human : 13
SpeciesGeneGeneIdGene NameEvidence
HumanE2F7144455E2F transcription factor 7
img Jax MP, Pubmed Id: 18194653, MOUSE PHENOTYPE ID: MGI:1289147
img Jax MP, Pubmed Id: 9582278, MOUSE PHENOTYPE ID: MGI:101786
img Jax MP, Pubmed Id: 16439206, MOUSE PHENOTYPE ID: MGI:1354161
img Jax MP, Pubmed Id: 22579044, MOUSE PHENOTYPE ID: MGI:1914403
img Jax MP, Pubmed Id: 21482716, MOUSE PHENOTYPE ID: MGI:104779
HumanSUV420H284787suppressor of variegation 4-20 homolog 2 (Drosophila)
INFERRED
HumanRNASEH2B79621ribonuclease H2, subunit B
img Jax MP, Pubmed Id: 9582278, MOUSE PHENOTYPE ID: MGI:101786
img Jax MP, Pubmed Id: 22579044, MOUSE PHENOTYPE ID: MGI:1914403
img Jax MP, Pubmed Id: 18194653, MOUSE PHENOTYPE ID: MGI:1289147
img Jax MP, Pubmed Id: 21482716, MOUSE PHENOTYPE ID: MGI:104779
img Jax MP, Pubmed Id: 16439206, MOUSE PHENOTYPE ID: MGI:1354161
HumanSIRT651548sirtuin 6
img Jax MP, Pubmed Id: 9582278, MOUSE PHENOTYPE ID: MGI:101786
img Jax MP, Pubmed Id: 22579044, MOUSE PHENOTYPE ID: MGI:1914403
img Jax MP, Pubmed Id: 16439206, MOUSE PHENOTYPE ID: MGI:1354161
img Jax MP, Pubmed Id: 21482716, MOUSE PHENOTYPE ID: MGI:104779
img Jax MP, Pubmed Id: 18194653, MOUSE PHENOTYPE ID: MGI:1289147
HumanATMIN23300ATM interactor
INFERRED
HumanSMC1A8243structural maintenance of chromosomes 1A
INFERRED
HumanTP53BP17158tumor protein p53 binding protein 1
INFERRED
HumanPRKDC5591protein kinase, DNA-activated, catalytic polypeptide
img Jax MP, Pubmed Id: 9582278, MOUSE PHENOTYPE ID: MGI:101786
img Jax MP, Pubmed Id: 21482716, MOUSE PHENOTYPE ID: MGI:104779
img Jax MP, Pubmed Id: 22579044, MOUSE PHENOTYPE ID: MGI:1914403
img Jax MP, Pubmed Id: 18194653, MOUSE PHENOTYPE ID: MGI:1289147
img Jax MP, Pubmed Id: 16439206, MOUSE PHENOTYPE ID: MGI:1354161
HumanMTF14520metal-regulatory transcription factor 1
img Jax MP, Pubmed Id: 21482716, MOUSE PHENOTYPE ID: MGI:104779
img Jax MP, Pubmed Id: 16439206, MOUSE PHENOTYPE ID: MGI:1354161
img Jax MP, Pubmed Id: 22579044, MOUSE PHENOTYPE ID: MGI:1914403
img Jax MP, Pubmed Id: 18194653, MOUSE PHENOTYPE ID: MGI:1289147
img Jax MP, Pubmed Id: 9582278, MOUSE PHENOTYPE ID: MGI:101786
HumanFANCC2176Fanconi anemia, complementation group C
INFERRED
HumanCHD21106chromodomain helicase DNA binding protein 2
INFERRED
HumanCDKN1A1026cyclin-dependent kinase inhibitor 1A (p21, Cip1)
INFERRED
HumanATR545ataxia telangiectasia and Rad3 related
INFERRED
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0008402increased cellular sensitivity to alkylating agents0self