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Details
Link-It Detail - Jax Mouse Phenotype - increased susceptibility to neuronal excitotoxicity
Debug Stats
  • ### Total Build Time: 97 ms 24.309 KB
  • CONCEPT_NAME gt=13 ms Completed: 13 ms rowSize= 430 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 337 bytes
  • CONCEPT_SYNONYM gt=0 Completed: 0 ms rowSize= 205 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
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  • CONCEPT_PARENTS gt=3 ms Completed: 3 ms rowSize= 1.042 KB
  • CONCEPT_CHILDREN gt=2 ms Completed: 2 ms rowSize= 618 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=11 ms Completed: 11 ms rowSize= 4.273 KB
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=65 ms Completed: 65 ms rowSize= 16.107 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.188 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Jax Mouse Phenotype (1)
increased susceptibility to neuronal excitotoxicity MP:0008235
Definition (1)
greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kainate-induced neuronal cell death mediated via a glutamate excitotoxic process
Synonyms (1)
"decreased resistance to neuronal excitotoxicity" EXACT
Parents (2)
img increased neuron apoptosis MP:0003203
img increased physiological sensitivity to xenobiotic MP:0008873
Children (1)
img increased susceptibility to dopaminergic neuron neurotoxicity MP:0011451
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img cellular phenotype MP:00053848img increased neuron apoptosis MP:0003203
img mammalian phenotype MP:0000001img nervous system phenotype MP:00036317img increased neuron apoptosis MP:0003203
img mammalian phenotype MP:0000001img homeostasis/metabolism phenotype MP:00053765img increased physiological sensitivity to xenobiotic MP:0008873
Genes (32)

Species:
human : 32
Page Size
Current 25
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Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanNPAS4266743neuronal PAS domain protein 4
Click here to display 37 evidence detail records.
HumanLYNX166004Ly6/neurotoxin 1
Click here to display 37 evidence detail records.
HumanGAL51083galanin/GMAP prepropeptide
Click here to display 37 evidence detail records.
HumanHTRA227429HtrA serine peptidase 2
Click here to display 37 evidence detail records.
HumanPARK711315parkinson protein 7
INFERRED
HumanHYOU110525hypoxia up-regulated 1
Click here to display 37 evidence detail records.
HumanAKT310000v-akt murine thymoma viral oncogene homolog 3
Click here to display 37 evidence detail records.
HumanRPS6KA59252ribosomal protein S6 kinase, 90kDa, polypeptide 5
Click here to display 37 evidence detail records.
HumanUCP27351uncoupling protein 2 (mitochondrial, proton carrier)
INFERRED
HumanTNFRSF1B7133tumor necrosis factor receptor superfamily, member 1B
Click here to display 37 evidence detail records.
HumanSLC22A36581solute carrier family 22 (organic cation transporter), member 3
INFERRED
HumanSLC18A26571solute carrier family 18 (vesicular monoamine transporter), member 2
INFERRED
HumanSLC6A36531solute carrier family 6 (neurotransmitter transporter), member 3
INFERRED
HumanCX3CL16376chemokine (C-X3-C motif) ligand 1
INFERRED
HumanPTGS25743prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Click here to display 37 evidence detail records.
HumanPSEN15663presenilin 1
Click here to display 37 evidence detail records.
HumanOGG149688-oxoguanine DNA glycosylase
Click here to display 37 evidence detail records.
HumanNR4A24929nuclear receptor subfamily 4, group A, member 2
Click here to display 37 evidence detail records.
HumanNTRK24915neurotrophic tyrosine kinase, receptor, type 2
INFERRED
HumanNOS34846nitric oxide synthase 3 (endothelial cell)
Click here to display 37 evidence detail records.
HumanNAIP4671NLR family, apoptosis inhibitory protein
Click here to display 37 evidence detail records.
HumanNUDT14521nudix (nucleoside diphosphate linked moiety X)-type motif 1
Click here to display 37 evidence detail records.
HumanIL63569interleukin 6 (interferon, beta 2)
INFERRED
HumanHPCA3208hippocalcin
Click here to display 37 evidence detail records.
HumanGRN2896granulin
INFERRED
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0008235increased susceptibility to neuronal excitotoxicity0self