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Details
Link-It Detail - Jax Mouse Phenotype - decreased germinal center B cell number
Debug Stats
  • ### Total Build Time: 255 ms 34.328 KB
  • CONCEPT_NAME gt=0 Completed: 0 ms rowSize= 406 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 449 bytes
  • CONCEPT_SYNONYM gt=0 Completed: 0 ms rowSize= 195 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=5 ms Completed: 5 ms rowSize= 1.039 KB
  • CONCEPT_CHILDREN gt=3 ms Completed: 3 ms rowSize= 587 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=4 ms Completed: 4 ms rowSize= 13.735 KB
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=240 ms Completed: 240 ms rowSize= 16.634 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.177 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Jax Mouse Phenotype (1)
decreased germinal center B cell number MP:0008178
Definition (1)
reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen
Synonyms (1)
"reduced germinal center B cell number" EXACT
Parents (2)
img abnormal germinal center B cell morphology MP:0008176
img decreased mature B cell number MP:0008211
Children (1)
img absent germinal center B cells MP:0008179
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img immune system phenotype MP:00053878img abnormal germinal center B cell morphology MP:0008176
img mammalian phenotype MP:0000001img immune system phenotype MP:000538711img abnormal germinal center B cell morphology MP:0008176
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539712img abnormal germinal center B cell morphology MP:0008176
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539711img abnormal germinal center B cell morphology MP:0008176
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539712img decreased mature B cell number MP:0008211
img mammalian phenotype MP:0000001img immune system phenotype MP:000538711img decreased mature B cell number MP:0008211
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539711img decreased mature B cell number MP:0008211
img mammalian phenotype MP:0000001img immune system phenotype MP:000538712img decreased mature B cell number MP:0008211
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539713img decreased mature B cell number MP:0008211
img mammalian phenotype MP:0000001img immune system phenotype MP:00053878img decreased mature B cell number MP:0008211
Genes (27)

Species:
human : 27
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SpeciesGeneGeneIdGene NameEvidence
HumanDOCK881704dedicator of cytokinesis 8
Click here to display 40 evidence detail records.
HumanBACH260468BTB and CNC homology 1, basic leucine zipper transcription factor 2
INFERRED
HumanIL2159067interleukin 21
Click here to display 40 evidence detail records.
HumanAICDA57379activation-induced cytidine deaminase
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HumanICOS29851inducible T-cell co-stimulator
Click here to display 40 evidence detail records.
HumanCD27429126CD274 molecule
Click here to display 40 evidence detail records.
HumanBATF10538basic leucine zipper transcription factor, ATF-like
INFERRED
HumanBCL2L1110018BCL2-like 11 (apoptosis facilitator)
Click here to display 40 evidence detail records.
HumanMCM3AP8888minichromosome maintenance complex component 3 associated protein
Click here to display 40 evidence detail records.
HumanCD848832CD84 molecule
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HumanTNFRSF47293tumor necrosis factor receptor superfamily, member 4
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HumanTRAF27186TNF receptor-associated factor 2
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HumanTNF7124tumor necrosis factor
INFERRED
HumanZEB16935zinc finger E-box binding homeobox 1
Click here to display 40 evidence detail records.
HumanREV3L5980REV3-like, polymerase (DNA directed), zeta, catalytic subunit
Click here to display 40 evidence detail records.
HumanPIK3CD5293phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Click here to display 40 evidence detail records.
HumanMCL14170myeloid cell leukemia sequence 1 (BCL2-related)
Click here to display 40 evidence detail records.
HumanSH2D1A4068SH2 domain containing 1A
Click here to display 40 evidence detail records.
HumanLTB4050lymphotoxin beta (TNF superfamily, member 3)
INFERRED
HumanGALNT12589UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
Click here to display 40 evidence detail records.
HumanEBF11879early B-cell factor 1
Click here to display 40 evidence detail records.
HumanCDH171015cadherin 17, LI cadherin (liver-intestine)
Click here to display 40 evidence detail records.
HumanCD79A973CD79a molecule, immunoglobulin-associated alpha
Click here to display 40 evidence detail records.
HumanCD40958CD40 molecule, TNF receptor superfamily member 5
INFERRED
HumanCD19930CD19 molecule
Click here to display 40 evidence detail records.
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0008178decreased germinal center B cell number0self