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Details
Link-It Detail - Jax Mouse Phenotype - abnormal Langerhans cell physiology
Debug Stats
  • ### Total Build Time: 118 ms 15.051 KB
  • CONCEPT_NAME gt=11 ms Completed: 11 ms rowSize= 398 bytes
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  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.579 KB
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  • CONCEPT_GENES gt=93 ms Completed: 93 ms rowSize= 9.839 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.173 KB
  • CONCEPT_ANCILLARY gt=2 ms Completed: 2 ms rowSize= 14 bytes
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Jax Mouse Phenotype (1)
abnormal Langerhans cell physiology MP:0005362
Definition (1)
atypical or failure of normal function of the stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus
Synonyms (1)
"abnormal Langerhans cell function" EXACT
Parents (1)
img abnormal dendritic cell physiology MP:0002376
Children (1)
img abnormal Langerhans cell antigen presentation MP:0002456
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img immune system phenotype MP:00053877img abnormal dendritic cell physiology MP:0002376
Genes (16)

Species:
human : 16
SpeciesGeneGeneIdGene NameEvidence
HumanCCR2729230chemokine (C-C motif) receptor 2
Click here to display 18 evidence detail records.
HumanSIRPA140885signal-regulatory protein alpha
Click here to display 18 evidence detail records.
HumanSUCNR156670succinate receptor 1
Click here to display 18 evidence detail records.
HumanIL21R50615interleukin 21 receptor
Click here to display 18 evidence detail records.
HumanXPA7507xeroderma pigmentosum, complementation group A
Click here to display 18 evidence detail records.
HumanFSCN16624fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
Click here to display 18 evidence detail records.
HumanPTGER45734prostaglandin E receptor 4 (subtype EP4)
Click here to display 18 evidence detail records.
HumanMMP94318matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
Click here to display 18 evidence detail records.
HumanMITF4286microphthalmia-associated transcription factor
Click here to display 18 evidence detail records.
HumanEPCAM4072epithelial cell adhesion molecule
Click here to display 18 evidence detail records.
HumanIL17A3605interleukin 17A
Click here to display 18 evidence detail records.
HumanIL103586interleukin 10
Click here to display 18 evidence detail records.
HumanIFNG3458interferon, gamma
Click here to display 18 evidence detail records.
HumanCSF1R1436colony stimulating factor 1 receptor
Click here to display 18 evidence detail records.
HumanCSF11435colony stimulating factor 1 (macrophage)
Click here to display 18 evidence detail records.
HumanAHR196aryl hydrocarbon receptor
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XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0005362abnormal Langerhans cell physiology0self