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Details
Link-It Detail - Jax Mouse Phenotype - abnormal level of surface class II molecules
Debug Stats
  • ### Total Build Time: 23 ms 21.547 KB
  • CONCEPT_NAME gt=0 Completed: 0 ms rowSize= 416 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 278 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 601 bytes
  • CONCEPT_CHILDREN gt=3 ms Completed: 3 ms rowSize= 1.539 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 5.662 KB
  • CONCEPT_RELATIONSHIPS gt=0 Completed: 0 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=19 ms Completed: 19 ms rowSize= 11.755 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.182 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Jax Mouse Phenotype (1)
abnormal level of surface class II molecules MP:0005042
Definition (1)
deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface
Parents (1)
img abnormal antigen presentation via MHC class II MP:0005041
Children (3)
img increased level of surface class II molecules MP:0010538
img abnormal MHC II cell surface expression on macrophages MP:0005040
img decreased level of surface class II molecules MP:0010539
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img immune system phenotype MP:000538710img abnormal antigen presentation via MHC class II MP:0005041
img mammalian phenotype MP:0000001img immune system phenotype MP:00053879img abnormal antigen presentation via MHC class II MP:0005041
img mammalian phenotype MP:0000001img immune system phenotype MP:00053877img abnormal antigen presentation via MHC class II MP:0005041
img mammalian phenotype MP:0000001img immune system phenotype MP:00053876img abnormal antigen presentation via MHC class II MP:0005041
Genes (20)

Species:
human : 20
SpeciesGeneGeneIdGene NameEvidence
HumanTIRAP114609toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Click here to display 32 evidence detail records.
HumanMARCH155016membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
Click here to display 32 evidence detail records.
HumanTLR47099toll-like receptor 4
Click here to display 32 evidence detail records.
HumanSTAT66778signal transducer and activator of transcription 6, interleukin-4 induced
Click here to display 32 evidence detail records.
HumanSTAT26773signal transducer and activator of transcription 2, 113kDa
Click here to display 32 evidence detail records.
HumanSTAT16772signal transducer and activator of transcription 1, 91kDa
INFERRED
HumanRFX55993regulatory factor X, 5 (influences HLA class II expression)
Click here to display 32 evidence detail records.
HumanRAG15896recombination activating gene 1
Click here to display 32 evidence detail records.
HumanPRKDC5591protein kinase, DNA-activated, catalytic polypeptide
Click here to display 32 evidence detail records.
HumanPRF15551perforin 1 (pore forming protein)
Click here to display 32 evidence detail records.
HumanCIITA4261class II, major histocompatibility complex, transactivator
Click here to display 32 evidence detail records.
HumanLYN4067v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Click here to display 32 evidence detail records.
HumanIL103586interleukin 10
Click here to display 32 evidence detail records.
HumanIL23558interleukin 2
Click here to display 32 evidence detail records.
HumanIFNG3458interferon, gamma
INFERRED
HumanHLA-DQB13119
Click here to display 32 evidence detail records.
HumanHLA-DQA13117
INFERRED
HumanHLA-DMA3108
Click here to display 32 evidence detail records.
HumanCSF21437colony stimulating factor 2 (granulocyte-macrophage)
INFERRED
HumanCD74972CD74 molecule, major histocompatibility complex, class II invariant chain
Click here to display 32 evidence detail records.
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0005042abnormal level of surface class II molecules0self