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Details
Link-It Detail - Jax Mouse Phenotype - abnormal class switch recombination
Debug Stats
  • ### Total Build Time: 947 ms 35.075 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 398 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 422 bytes
  • CONCEPT_SYNONYM gt=0 Completed: 0 ms rowSize= 170 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=13 ms Completed: 13 ms rowSize= 1.478 KB
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=1 ms Completed: 1 ms rowSize= 13.660 KB
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=924 ms Completed: 924 ms rowSize= 17.646 KB
  • CONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.173 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
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Jax Mouse Phenotype (1)
abnormal class switch recombination MP:0004816
Definition (1)
anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions
Synonyms (1)
"abnormal CSR" EXACT
Parents (3)
img abnormal B cell differentiation MP:0002144
img abnormal B cell physiology MP:0002459
img abnormal adaptive immunity MP:0002420
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img immune system phenotype MP:000538710img abnormal B cell differentiation MP:0002144
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539711img abnormal B cell differentiation MP:0002144
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539710img abnormal B cell differentiation MP:0002144
img mammalian phenotype MP:0000001img immune system phenotype MP:00053879img abnormal B cell differentiation MP:0002144
img mammalian phenotype MP:0000001img cellular phenotype MP:00053848img abnormal B cell differentiation MP:0002144
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:00053979img abnormal B cell differentiation MP:0002144
img mammalian phenotype MP:0000001img immune system phenotype MP:00053878img abnormal B cell differentiation MP:0002144
img mammalian phenotype MP:0000001img immune system phenotype MP:00053878img abnormal B cell physiology MP:0002459
img mammalian phenotype MP:0000001img immune system phenotype MP:00053877img abnormal B cell physiology MP:0002459
img mammalian phenotype MP:0000001img immune system phenotype MP:00053875img abnormal adaptive immunity MP:0002420
Genes (75)

Species:
human : 75
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SpeciesGeneGeneIdGene NameEvidence
HumanAPLF200558aprataxin and PNKP like factor
Click here to display 155 evidence detail records.
HumanTNFRSF13C115650tumor necrosis factor receptor superfamily, member 13C
Click here to display 155 evidence detail records.
HumanSPPL2A84888signal peptide peptidase like 2A
Click here to display 155 evidence detail records.
HumanNFKBID84807nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
Click here to display 155 evidence detail records.
HumanSUV420H284787suppressor of variegation 4-20 homolog 2 (Drosophila)
Click here to display 155 evidence detail records.
HumanZC3H12A80149zinc finger CCCH-type containing 12A
Click here to display 155 evidence detail records.
HumanNHEJ179840nonhomologous end-joining factor 1
Click here to display 155 evidence detail records.
HumanDCLRE1C64421DNA cross-link repair 1C
Click here to display 155 evidence detail records.
HumanBACH260468BTB and CNC homology 1, basic leucine zipper transcription factor 2
Click here to display 155 evidence detail records.
HumanIL2159067interleukin 21
Click here to display 155 evidence detail records.
HumanAICDA57379activation-induced cytidine deaminase
Click here to display 155 evidence detail records.
HumanRIF155183RAP1 interacting factor homolog (yeast)
Click here to display 155 evidence detail records.
HumanICOS29851inducible T-cell co-stimulator
Click here to display 155 evidence detail records.
HumanTBK129110TANK-binding kinase 1
Click here to display 155 evidence detail records.
HumanTNFRSF13B23495tumor necrosis factor receptor superfamily, member 13B
Click here to display 155 evidence detail records.
HumanICOSLG23308inducible T-cell co-stimulator ligand
Click here to display 155 evidence detail records.
HumanSWAP7023075SWAP switching B-cell complex 70kDa subunit
Click here to display 155 evidence detail records.
HumanRUVBL210856RuvB-like 2 (E. coli)
Click here to display 155 evidence detail records.
HumanBATF10538basic leucine zipper transcription factor, ATF-like
Click here to display 155 evidence detail records.
HumanMDC19656mediator of DNA-damage checkpoint 1
Click here to display 155 evidence detail records.
HumanMAP3K149020mitogen-activated protein kinase kinase kinase 14
Click here to display 155 evidence detail records.
HumanTNFSF138741tumor necrosis factor (ligand) superfamily, member 13
Click here to display 155 evidence detail records.
HumanZAP707535zeta-chain (TCR) associated protein kinase 70kDa
Click here to display 155 evidence detail records.
HumanXRCC57520X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Click here to display 155 evidence detail records.
HumanXRCC47518X-ray repair complementing defective repair in Chinese hamster cells 4
Click here to display 155 evidence detail records.
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0004816abnormal class switch recombination0self