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Details
Link-It Detail - Jax Mouse Phenotype - abnormal microglial cell physiology
Debug Stats
  • ### Total Build Time: 105 ms 24.650 KB
  • CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 398 bytes
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  • CONCEPT_GENES gt=98 ms Completed: 98 ms rowSize= 16.135 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.173 KB
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Jax Mouse Phenotype (1)
abnormal microglial cell physiology MP:0003691
Definition (1)
any functional anomaly of the small, migratory, phagocytic, interstitial cells derived from myeloid progenitor cells and found in the parenchyma of the central nervous system; microglia are scavengers, engulfing dead cells and other debris, and in Alzheimer's disease, microglia are found associated with dying nerve cells and amyloid plaques
Parents (2)
img abnormal macrophage physiology MP:0002451
img abnormal glial cell physiology MP:0003690
Children (2)
img abnormal microglial cell activation MP:0010762
img abnormal microglial cell chemotaxis MP:0010761
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img immune system phenotype MP:00053877img abnormal macrophage physiology MP:0002451
img mammalian phenotype MP:0000001img immune system phenotype MP:00053876img abnormal macrophage physiology MP:0002451
img mammalian phenotype MP:0000001img nervous system phenotype MP:00036315img abnormal glial cell physiology MP:0003690
Genes (36)

Species:
human : 36
Page Size
Current 25
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Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanCCR2729230chemokine (C-C motif) receptor 2
Click here to display 34 evidence detail records.
HumanCCL3L3414062chemokine (C-C motif) ligand 3-like 3
INFERRED
HumanTICAM1148022toll-like receptor adaptor molecule 1
Click here to display 34 evidence detail records.
HumanNEIL355247nei endonuclease VIII-like 3 (E. coli)
INFERRED
HumanVPS5451542vacuolar protein sorting 54 homolog (S. cerevisiae)
INFERRED
HumanTNFRSF1B7133tumor necrosis factor receptor superfamily, member 1B
INFERRED
HumanTLR47099toll-like receptor 4
Click here to display 34 evidence detail records.
HumanTLR27097toll-like receptor 2
INFERRED
HumanCCL136357chemokine (C-C motif) ligand 13
Click here to display 34 evidence detail records.
HumanCCL3L16349chemokine (C-C motif) ligand 3-like 1
INFERRED
HumanPTPN65777protein tyrosine phosphatase, non-receptor type 6
INFERRED
HumanPTGER25732prostaglandin E receptor 2 (subtype EP2), 53kDa
Click here to display 34 evidence detail records.
HumanPSEN15663presenilin 1
Click here to display 34 evidence detail records.
HumanPSAP5660prosaposin
Click here to display 34 evidence detail records.
HumanPLG5340plasminogen
Click here to display 34 evidence detail records.
HumanPLAT5327plasminogen activator, tissue
Click here to display 34 evidence detail records.
HumanNPC14864Niemann-Pick disease, type C1
Click here to display 34 evidence detail records.
HumanMT1E4493metallothionein 1E
Click here to display 34 evidence detail records.
HumanCD2004345CD200 molecule
Click here to display 34 evidence detail records.
HumanLYN4067v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Click here to display 34 evidence detail records.
HumanLEP3952leptin
Click here to display 34 evidence detail records.
HumanLDLR3949low density lipoprotein receptor
Click here to display 34 evidence detail records.
HumanIL63569interleukin 6 (interferon, beta 2)
Click here to display 34 evidence detail records.
HumanIFNB13456interferon, beta 1, fibroblast
Click here to display 34 evidence detail records.
HumanIDUA3425iduronidase, alpha-L-
Click here to display 34 evidence detail records.
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0003691abnormal microglial cell physiology0self