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Details
Link-It Detail - Jax Mouse Phenotype - abnormal circulating renin level
Debug Stats
  • ### Total Build Time: 288 ms 18.858 KB
  • CONCEPT_NAME gt=5 ms Completed: 5 ms rowSize= 392 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 285 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=10 ms Completed: 10 ms rowSize= 588 bytes
  • CONCEPT_CHILDREN gt=9 ms Completed: 9 ms rowSize= 1.035 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=1 ms Completed: 1 ms rowSize= 2.939 KB
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=256 ms Completed: 256 ms rowSize= 12.334 KB
  • CONCEPT_XREFS gt=4 ms Completed: 4 ms rowSize= 1.170 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Jax Mouse Phenotype (1)
abnormal circulating renin level MP:0003349
Definition (1)
aberrant blood level of the enzyme which is secreted by the kidney and cleaves a bond in angiotensionogen to generate angiotensin I
Parents (1)
img abnormal circulating enzyme level MP:0001570
Children (2)
img decreased circulating renin level MP:0003353
img increased circulating renin level MP:0003352
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img homeostasis/metabolism phenotype MP:00053766img abnormal circulating enzyme level MP:0001570
img mammalian phenotype MP:0000001img homeostasis/metabolism phenotype MP:00053767img abnormal circulating enzyme level MP:0001570
Genes (24)

Species:
human : 24
SpeciesGeneGeneIdGene NameEvidence
HumanNCF1653361neutrophil cytosolic factor 1
INFERRED
HumanWNK465266WNK lysine deficient protein kinase 4
INFERRED
HumanSLC4A557835solute carrier family 4 (sodium bicarbonate cotransporter), member 5
INFERRED
HumanSUCNR156670succinate receptor 1
INFERRED
HumanVAV310451vav 3 guanine nucleotide exchange factor
INFERRED
HumanVAMP88673vesicle-associated membrane protein 8
INFERRED
HumanSLC4A48671solute carrier family 4 (sodium bicarbonate cotransporter), member 4
INFERRED
HumanVDR7421vitamin D (1,25- dihydroxyvitamin D3) receptor
INFERRED
HumanVAV27410vav 2 guanine nucleotide exchange factor
INFERRED
HumanTGFB17040transforming growth factor, beta 1
INFERRED
HumanSLC12A16557solute carrier family 12 (sodium/potassium/chloride transporter), member 1
INFERRED
HumanREN5972renin
INFERRED
HumanNPR14881natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
INFERRED
HumanNOS34846nitric oxide synthase 3 (endothelial cell)
INFERRED
HumanMYH114629myosin, heavy chain 11, smooth muscle
INFERRED
HumanNR3C24306nuclear receptor subfamily 3, group C, member 2
INFERRED
HumanKCNK33777potassium channel, subfamily K, member 3
INFERRED
HumanKCNE13753potassium voltage-gated channel, Isk-related family, member 1
img Jax MP, Pubmed Id: 11438691, MOUSE PHENOTYPE ID: MGI:96673
HumanELN2006elastin
INFERRED
HumanACE1636angiotensin I converting enzyme
INFERRED
HumanCYP11B21585cytochrome P450, family 11, subfamily B, polypeptide 2
INFERRED
HumanCYP11B11584cytochrome P450, family 11, subfamily B, polypeptide 1
INFERRED
HumanAGTR1185angiotensin II receptor, type 1
INFERRED
HumanAGT183angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
INFERRED
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0003349abnormal circulating renin level0self