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Details
Link-It Detail - Jax Mouse Phenotype - abnormal macrophage physiology
Debug Stats
  • ### Total Build Time: 1,751 ms 30.396 KB
  • CONCEPT_NAME gt=14 ms Completed: 14 ms rowSize= 388 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 432 bytes
  • CONCEPT_SYNONYM gt=0 Completed: 0 ms rowSize= 180 bytes
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  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
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  • CONCEPT_PARENTS gt=1 ms Completed: 1 ms rowSize= 1.503 KB
  • CONCEPT_CHILDREN gt=5 ms Completed: 5 ms rowSize= 4.750 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 4.276 KB
  • CONCEPT_RELATIONSHIPS gt=0 Completed: 0 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=1,726 ms Completed: 1.726 Seconds rowSize= 17.578 KB
  • CONCEPT_XREFS gt=5 ms Completed: 5 ms rowSize= 1.168 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
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Jax Mouse Phenotype (1)
abnormal macrophage physiology MP:0002451
Definition (1)
any functional anomaly of the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells
Synonyms (1)
"macrophage dysfunction" EXACT
Parents (3)
img abnormal leukocyte physiology MP:0002442
img abnormal professional antigen presenting cell physiology MP:0002452
img abnormal innate immunity MP:0002419
Children (10)
img impaired macrophage phagocytosis MP:0001798
img abnormal macrophage nitric oxide production MP:0011074
img abnormal macrophage chemotaxis MP:0010760
img abnormal macrophage cytokine production MP:0011072
img abnormal macrophage antigen presentation MP:0002454
img abnormal microglial cell physiology MP:0003691
img abnormal macrophage apoptosis MP:0011073
img abnormal macrophage activation involved in immune response MP:0011075
img abnormal macrophage proliferation MP:0011985
img abnormal osteoclast physiology MP:0001541
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img immune system phenotype MP:00053876img abnormal leukocyte physiology MP:0002442
img mammalian phenotype MP:0000001img immune system phenotype MP:00053876img abnormal professional antigen presenting cell physiology MP:0002452
img mammalian phenotype MP:0000001img immune system phenotype MP:00053875img abnormal innate immunity MP:0002419
Genes (335)

Species:
human : 335
Page Size
Current 25
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Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanCCR2729230chemokine (C-C motif) receptor 2
INFERRED
HumanNCF1653361neutrophil cytosolic factor 1
Click here to display 317 evidence detail records.
HumanCCL3L3414062chemokine (C-C motif) ligand 3-like 3
INFERRED
HumanPELI3246330pellino E3 ubiquitin protein ligase family member 3
INFERRED
HumanUNC13D201294unc-13 homolog D (C. elegans)
Click here to display 317 evidence detail records.
HumanTICAM1148022toll-like receptor adaptor molecule 1
Click here to display 317 evidence detail records.
HumanCCBE1147372collagen and calcium binding EGF domains 1
Click here to display 317 evidence detail records.
HumanSIRPA140885signal-regulatory protein alpha
Click here to display 317 evidence detail records.
HumanIL31RA133396interleukin 31 receptor A
Click here to display 317 evidence detail records.
HumanSPIC121599Spi-C transcription factor (Spi-1/PU.1 related)
INFERRED
HumanPGLYRP2114770peptidoglycan recognition protein 2
Click here to display 317 evidence detail records.
HumanTIRAP114609toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Click here to display 317 evidence detail records.
HumanNLRP3114548NLR family, pyrin domain containing 3
Click here to display 317 evidence detail records.
HumanTIMD491937T-cell immunoglobulin and mucin domain containing 4
Click here to display 317 evidence detail records.
HumanHVCN184329hydrogen voltage-gated channel 1
Click here to display 317 evidence detail records.
HumanZMYND1584225zinc finger, MYND-type containing 15
Click here to display 317 evidence detail records.
HumanUNC93B181622unc-93 homolog B1 (C. elegans)
Click here to display 317 evidence detail records.
HumanDCSTAMP81501dendrocyte expressed seven transmembrane protein
Click here to display 317 evidence detail records.
HumanNLRX179671NLR family member X1
Click here to display 317 evidence detail records.
HumanTNFAIP8L279626tumor necrosis factor, alpha-induced protein 8-like 2
INFERRED
HumanTNIP279155TNFAIP3 interacting protein 2
Click here to display 317 evidence detail records.
HumanMMP2879148matrix metallopeptidase 28
INFERRED
HumanMARCKSL165108MARCKS-like 1
Click here to display 317 evidence detail records.
HumanCLEC7A64581C-type lectin domain family 7, member A
Click here to display 317 evidence detail records.
HumanCARD964170caspase recruitment domain family, member 9
Click here to display 317 evidence detail records.
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0002451abnormal macrophage physiology0self