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Details
Link-It Detail - Jax Mouse Phenotype - abnormal humoral immune response
Debug Stats
  • ### Total Build Time: 780 ms 21.623 KB
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  • CONCEPT_GENES gt=771 ms Completed: 771 ms rowSize= 15.882 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.170 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Jax Mouse Phenotype (1)
abnormal humoral immune response MP:0001800
Definition (1)
any functional anomaly of the aspect of immunity that is mediated by secreted antibodies produced in the cells of the B lymphocyte lineage (B cell) and the accessory processes that accompany it, including Th2 activation and cytokine production, germinal center formation and isotype switching, affinity maturation and memory cell generation; it also refers to the effector functions of antibody, which include pathogen and toxin neutralization, classical complement activation, and opsonin promotion of phagocytosis and pathogen elimination
Synonyms (1)
"humoral immune response dysfunction" EXACT
Parents (1)
img abnormal immune system physiology MP:0001790
Children (2)
img abnormal complement pathway MP:0002471
img abnormal immunoglobulin level MP:0002490
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img immune system phenotype MP:00053874img abnormal immune system physiology MP:0001790
Genes (419)

Species:
human : 419
Page Size
Current 25
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Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanCOMMD3-BMI1100532731
INFERRED
HumanGIMAP1-GIMAP5100527949
INFERRED
HumanIGLL5100423062immunoglobulin lambda-like polypeptide 5
INFERRED
HumanCCR2729230chemokine (C-C motif) receptor 2
INFERRED
HumanINCA1388324inhibitor of CDK, cyclin A1 interacting protein 1
INFERRED
HumanNLRP10338322NLR family, pyrin domain containing 10
INFERRED
HumanATP11C286410ATPase, class VI, type 11C
Click here to display 177 evidence detail records.
HumanCLEC9A283420C-type lectin domain family 9, member A
Click here to display 177 evidence detail records.
HumanTAB3257397TGF-beta activated kinase 1/MAP3K7 binding protein 3
INFERRED
HumanGAPT202309GRB2-binding adaptor protein, transmembrane
INFERRED
HumanNLRP6171389NLR family, pyrin domain containing 6
INFERRED
HumanBTLA151888B and T lymphocyte associated
Click here to display 177 evidence detail records.
HumanRC3H1149041ring finger and CCCH-type domains 1
INFERRED
HumanTICAM1148022toll-like receptor adaptor molecule 1
INFERRED
HumanDSG4147409desmoglein 4
INFERRED
HumanTOM1L2146691target of myb1-like 2 (chicken)
Click here to display 177 evidence detail records.
HumanIL31RA133396interleukin 31 receptor A
INFERRED
HumanFCRLB127943Fc receptor-like B
INFERRED
HumanGABPB2126626GA binding protein transcription factor, beta subunit 2
INFERRED
HumanSPNS2124976spinster homolog 2 (Drosophila)
Click here to display 177 evidence detail records.
HumanPIK3AP1118788phosphoinositide-3-kinase adaptor protein 1
INFERRED
HumanTNFRSF13C115650tumor necrosis factor receptor superfamily, member 13C
Click here to display 177 evidence detail records.
HumanTIRAP114609toll-interleukin 1 receptor (TIR) domain containing adaptor protein
INFERRED
HumanIL17F112744interleukin 17F
INFERRED
HumanFNIP196459folliculin interacting protein 1
INFERRED
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0001800abnormal humoral immune response0self