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Details
Link-It Detail - Gene Ontology: Biological Processes - isotype switching
Debug Stats
  • ### Total Build Time: 48 ms 52.095 KB
  • CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 358 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_DEFINITION gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_NAMESPACE gt=0 Completed: 0 ms rowSize= 170 bytes
  • CONCEPT_PARENTS gt=5 ms Completed: 5 ms rowSize= 1.014 KB
  • CONCEPT_CHILDREN gt=3 ms Completed: 3 ms rowSize= 3.099 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=10 ms Completed: 10 ms rowSize= 21.767 KB
  • CONCEPT_RELATIONSHIPS gt=0 Completed: 0 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=28 ms Completed: 28 ms rowSize= 24.436 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.120 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Gene Ontology: Biological Processes (1)
isotype switching GO:0045190
Namespace (1)
biological_process
Parents (2)
img somatic recombination of immunoglobulin genes involved in immune response GO:0002204
img B cell activation involved in immune response GO:0002312
Children (7)
img isotype switching to IgD isotypes GO:0048292
img isotype switching to IgG isotypes GO:0048291
img negative regulation of isotype switching GO:0045829
img regulation of isotype switching GO:0045191
img isotype switching to IgA isotypes GO:0048290
img isotype switching to IgE isotypes GO:0048289
img positive regulation of isotype switching GO:0045830
Ancestral Roots
RootRoot Plus OneDepthParent
img biological_process GO:0008150img immune system process GO:00023768img somatic recombination of immunoglobulin genes involved in immune response GO:0002204
img biological_process GO:0008150img multicellular organismal process GO:003250111img somatic recombination of immunoglobulin genes involved in immune response GO:0002204
img biological_process GO:0008150img single-organism process GO:004469911img somatic recombination of immunoglobulin genes involved in immune response GO:0002204
img biological_process GO:0008150img developmental process GO:003250210img somatic recombination of immunoglobulin genes involved in immune response GO:0002204
img biological_process GO:0008150img immune system process GO:00023767img somatic recombination of immunoglobulin genes involved in immune response GO:0002204
img biological_process GO:0008150img metabolic process GO:000815213img somatic recombination of immunoglobulin genes involved in immune response GO:0002204
img biological_process GO:0008150img metabolic process GO:000815212img somatic recombination of immunoglobulin genes involved in immune response GO:0002204
img biological_process GO:0008150img cellular process GO:000998713img somatic recombination of immunoglobulin genes involved in immune response GO:0002204
img biological_process GO:0008150img metabolic process GO:000815211img somatic recombination of immunoglobulin genes involved in immune response GO:0002204
img biological_process GO:0008150img cellular process GO:000998711img somatic recombination of immunoglobulin genes involved in immune response GO:0002204
img biological_process GO:0008150img immune system process GO:000237611img somatic recombination of immunoglobulin genes involved in immune response GO:0002204
img biological_process GO:0008150img response to stimulus GO:005089611img somatic recombination of immunoglobulin genes involved in immune response GO:0002204
img biological_process GO:0008150img immune system process GO:00023767img B cell activation involved in immune response GO:0002312
img biological_process GO:0008150img single-organism process GO:00446999img B cell activation involved in immune response GO:0002312
img biological_process GO:0008150img cellular process GO:00099879img B cell activation involved in immune response GO:0002312
img biological_process GO:0008150img immune system process GO:00023768img B cell activation involved in immune response GO:0002312
img biological_process GO:0008150img response to stimulus GO:00508968img B cell activation involved in immune response GO:0002312
Genes (72)

Species:
human : 35
mouse : 37
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SpeciesGeneGeneIdGene NameEvidence
MouseMir181b-2723903
MouseMir181b-1723890
MouseLig4319583ligase IV, DNA, ATP-dependent
img GO IMP, Pubmed Id: 17713479, Gene Ontology ID: GO:0045190
MouseXrcc4108138X-ray repair complementing defective repair in Chinese hamster cells 4
img GO IMP, Pubmed Id: 17713479, Gene Ontology ID: GO:0045190
MouseExosc672544exosome component 6
img GO IMP, Gene Ontology ID: GO:0045190
MouseRnf16870238ring finger protein 168, E3 ubiquitin protein ligase
img GO IMP, Gene Ontology ID: GO:0045190
MouseTnfsf1369583tumor necrosis factor (ligand) superfamily, member 13
MouseExosc366362exosome component 3
img GO IMP, Gene Ontology ID: GO:0045190
MouseNdfip165113Nedd4 family interacting protein 1
MouseRnf858230ring finger protein 8, E3 ubiquitin protein ligase
img GO IMP, Gene Ontology ID: GO:0045190
MouseTbx2157765T-box 21
MouseClcf156708cardiotrophin-like cytokine factor 1
MousePaxip155982PAX interacting (with transcription-activation domain) protein 1
MouseBatf53314basic leucine zipper transcription factor, ATF-like
img GO IMP, Gene Ontology ID: GO:0045190
MouseIl27ra50931interleukin 27 receptor, alpha
MouseIcosl50723icos ligand
img GO NAS, Pubmed Id: 11343122, Gene Ontology ID: GO:0045190
MouseNbn27354nibrin
img GO IDA, Pubmed Id: 15668383, Gene Ontology ID: GO:0045190
MouseExo126909exonuclease 1
img GO IMP, Pubmed Id: 14716311, Gene Ontology ID: GO:0045190
MouseTnfsf422164tumor necrosis factor (ligand) superfamily, member 4
MouseCd40lg21947CD40 ligand
img GO IDA, Pubmed Id: 7529792, Gene Ontology ID: GO:0045190
MouseCd4021939CD40 molecule, TNF receptor superfamily member 5
MouseTgfb121803transforming growth factor, beta 1
MouseSwap7020947SWAP switching B-cell complex 70kDa subunit
img GO IDA, Pubmed Id: 9642267, Gene Ontology ID: GO:0045190
MouseStat620852signal transducer and activator of transcription 6, interleukin-4 induced
MouseFoxp320371forkhead box P3
XRefs (1)

XRef Types:
go : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
GOimg GO:0045190isotype switching0self