Human | ATAD3A | 55210 | ATPase family, AAA domain containing 3A | We also have shown that the loss of ATAD 3A/3B may be involved in the transformation pathway and the chemosensitivity of oligodendrogliomas |
Human | ING4 | 51147 | inhibitor of growth family, member 4 | ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells |
Human | LATS2 | 26524 | large tumor suppressor kinase 2 | Kpm/Lats2 is involved in the fate of p73 through the phosphorylation of YAP2 by Kpm/Lats2 and the induction of p73 target genes that underlie chemosensitivity of leukemic cells |
Human | PDCD5 | 9141 | programmed cell death 5 | exogenous PDCD5 expression enhances the chemosensitivity of K562 leukemia cells to either low or high doses of idarubicin in vitro, resulting in increased apoptosis |
Human | TNFSF10 | 8743 | tumor necrosis factor (ligand) superfamily, member 10 | Data suggest that interferon-gamma sensitizes resistant Ewing's sarcoma cells to TRAIL-induced apoptosis by up-regulation of caspase-8 without altering chemosensitivity |
Human | TP63 | 8626 | tumor protein p63 | described an important role for TAp63alpha in the induction of apoptosis and chemosensitivity |
Human | TP53 | 7157 | tumor protein p53 | expression of p53 is essential for cytotoxic effect of cisplatin in human malignant glioblastoma cells, A172 and T98G, and introduction of apoptotic signal molecules, such as p53, will be beneficial to achieve chemosensitivity in malignant glioma high and low P-glycoprotein, glutathione S-transferase pi expression, excision repair cross-complementing 1 alterations, and tumor suppressor p53 mutation were candidates for future clinical trials of chemosensitivity tests in lung cancer patients p53 pathway mediates in part growth suppression by NaB and the p53 status may be an important determinant of chemosensitivity in HDI based cancer chemotherapy Title:Association of p53 gene mutation with decreased chemosensitivity in human malignant gliomas.|Association:Y|Conclusion:Not Found |
Human | RB1 | 5925 | retinoblastoma 1 | Retinoblastoma deficiency increases chemosensitivity in lung cancer |
Human | NEUROD1 | 4760 | neuronal differentiation 1 | NEUROD1 methylation is a chemosensitivity marker in estrogen receptor-negative breast cancer |
Human | IL8 | 3576 | interleukin 8 | The IL-8 is increased of native human acute myelogenous leukemia (AML) blasts and nonleukemic cells in the bone marrow microenvironment seem important both for disease development chemosensitivity |
Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | IL-6 can induce cell proliferation and neuroendocrine(NE) dedifferentiation but has little effect on chemosensitivity in IL-6 receptor-expressing NSCLC-NE cells |
Human | IGF1R | 3480 | insulin-like growth factor 1 receptor | Suppression of IGF1R gene expression by shRNA enhances the chemosensitivity of A549 cells to DDP both in vitro and in vivo |
Human | MTOR | 2475 | mechanistic target of rapamycin (serine/threonine kinase) | mTOR inhibition enhances chemosensitivity in hepatocellular carcinoma |
Human | FGF2 | 2247 | fibroblast growth factor 2 (basic) | Results suggest that the release of bFGF following cell death contributes to enhanced chemosensitivity in Non-Small-Cell Lung Carcinoma (NSCLC) cell lines |
Human | FASN | 2194 | fatty acid synthase | breast cancer-associated FAS plays an active role in human breast cancer chemosensitivity |
Human | EGFR | 1956 | epidermal growth factor receptor | Association of epidermal growth factor receptor mutations in lung cancer with chemosensitivity to gefitinib in isolated cancer cells from male and female Japanese patients |
Human | CTNNA1 | 1495 | catenin (cadherin-associated protein), alpha 1, 102kDa | prognostic and chemosensitivity marker for invasive bladder cancer |
Human | CDKN2A | 1029 | cyclin-dependent kinase inhibitor 2A | p16 and p14ARF have roles in radio- and chemosensitivity of malignant gliomas |
Human | CDKN1A | 1026 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | p21 might play an important role in chemosensitivity to anticancer agents |
Human | CDH1 | 999 | cadherin 1, type 1, E-cadherin (epithelial) | E-cadherin affected the regulation of cell proliferation, differentiation and adhesion, and decreased chemosensitivity |
Human | CDA | 978 | cytidine deaminase | 6 SNPs ( -92A>G, -205C>G, -451C>T, -897C>A, -1075A>G and -1181G>A) in promoter of CDA may influence Ara-C chemosensitivity |
Human | BRCA1 | 672 | breast cancer 1, early onset | Specific chemosensitivity profile of BRCA1-defective breast cancer cells in vitro, which is dependent on BRCA1 protein expression |
Human | BNIP3 | 664 | BCL2/adenovirus E1B 19kDa interacting protein 3 | High levels of BNIP3 expression cannot be used as one of the predicting factors for gemcitabine chemosensitivity of pancreatic neoplasms |
Human | BID | 637 | BH3 interacting domain death agonist | Activator BH3-only occupation of BCL2 may prime cancer cells for death, offering a potential explanation for the marked chemosensitivity of certain cancers |
Human | CCND1 | 595 | cyclin D1 | Ectopic cyclin D1 overexpression increases chemosensitivity but not cell proliferation in multiple myeloma cyclin D1 has a role in cisplatin chemosensitivity in oral squamous cell carcinoma |