Human | LOC100507436 | 100507436 | | data provide little support for the hypothesis that MICA alleles substantially affect recovery from HCV and HBV infections MICA is induced on dendritic cells upon IFN-alpha stimulation and is capable of activating NK cells by a mechanism that is impaired in hepatitis C virus infection MICA-NKG2D interaction constitutes a mechanism by which monocytes and NK cells as an early source of IFN-gamma may communicate directly during an innate immune response to infections in humans the MICA-A4 allele shows a tendency to be protective against infection by Brucella melitensis |
Human | CCR2 | 729230 | chemokine (C-C motif) receptor 2 | Click here to display 5 evidence detail records. |
Human | SFTPA1 | 653509 | surfactant protein A1 | role in Aspergillus mediated allergies and infections |
Human | RICTOR | 253260 | RPTOR independent companion of MTOR, complex 2 | These data suggest that, during HCMV infection, the rictor- and raptor-containing complexes are modified such that their substrate specificities and rapamycin sensitivities are altered |
Human | IL27 | 246778 | interleukin 27 | These results implicate IL-12 and IL-27 in regulating human macrophages, and IL-27 derived from macrophages during infection impedes control of Mycobacterium tuberculosis growth |
Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | Infection by Trypanosoma brucei brucei causes hemolysis that triggers activation of trypanosome lytic factor by formation of haptoglobin-related protein-hemoglobin complexes, enhancing binding, trypanolytic activity, and clearance of parasites [TLF] |
Human | NFAM1 | 150372 | NFAT activating protein with ITAM motif 1 | NFAT plays a role in SV40 infection via transcriptional control of Simian Virus 40 |
Human | FGD4 | 121512 | FYVE, RhoGEF and PH domain containing 4 | role of frabin, a guanine nucleotide exchange factor specific for Cdc42, in the activation of Cdc42 during Cryptosporidium parvum infection of biliary epithelial cells |
Human | TIRAP | 114609 | toll-interleukin 1 receptor (TIR) domain containing adaptor protein | A polymorphism modulating innate immunity signal transduction has recently been shown to influence human susceptibility to many different infections |
Human | NLRP3 | 114548 | NLR family, pyrin domain containing 3 | functional expression of NLRP3 in osteoblasts provides potential mechanism underlying apoptotic cell death of these cells after challenge with intracellular bacterial pathogens & may be significant contributory factor to bone loss at sites of infection |
Human | SAT2 | 112483 | spermidine/spermine N1-acetyltransferase family member 2 | expression of SSAT mediated by Ad-SSAT infection inhibits the growth of colorectal cancer cells |
Human | TRIM5 | 85363 | tripartite motif containing 5 | Click here to display 5 evidence detail records. |
Human | MAP1LC3A | 84557 | microtubule-associated protein 1 light chain 3 alpha | Modification of LC3 occurs both during poliovirus infection and following expression of a single viral protein, a stable precursor termed 2BC |
Human | ANTXR1 | 84168 | anthrax toxin receptor 1 | This is the first demonstration that the ATR/TEM8 protein is highly expressed in epithelial cells, suggesting that the ATR/TEM8 expression pattern is highly relevant for understanding the pathogenesis of anthrax infection |
Human | PDCD1LG2 | 80380 | programmed cell death 1 ligand 2 | HRV-16 infection or exposure to dsRNA induces epithelial B7-H1 and B7-DC |
Human | C7orf49 | 78996 | chromosome 7 open reading frame 49 | Characterizes the hamster ortholog and suggests that it may modulate the ability of the proteasome to degrade retroviral cores upon cellular infection |
Human | APOBEC3G | 60489 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | These findings indicate that APOBEC3G could suppress HBV replication and antigen expression both in vivo and in vitro, promising an advance in treatment of HBV infection APOBEC3G is incorporated into HTLV-1 virions and inhibits the infection of HTLV-1 through different mechanisms from that on HIV-1 APOBEC3G-restricts HIV-1 infection in resting CD4+ T cells, which may not be strictly dependent on deoxycytidine deamination |
Human | ACE2 | 59272 | angiotensin I converting enzyme 2 | Here we show that transgenic mice that express the SARS-CoV receptor (human angiotensin-converting enzyme 2 [hACE2]) in airway and other epithelia develop a rapidly lethal infection after intranasal inoculation with a human strain of the virus A lower-affinity interaction with ACE-2 may partly explain the different pathological consequences of infection by SARS-Coronavirus and NL63 coronavirus SARS coronavirus airway epithelial infection is associated with ACE2 expression and localization (review) |
Human | IL21 | 59067 | interleukin 21 | IL-21 has a physiological role in immunity, infection, and cancer [review] |
Human | HAMP | 57817 | hepcidin antimicrobial peptide | Elevated basal hepcidin levels in the liver may inhibit the development of malaria infection |
Human | MAVS | 57506 | mitochondrial antiviral signaling protein | HCV infection transiently induces RIG-I- and IPS-1-dependent IRF-3 activation |
Human | CCL28 | 56477 | chemokine (C-C motif) ligand 28 | CCL28 mediates mucosal immunity in HIV exposure and infection |
Human | APOM | 55937 | apolipoprotein M | Apolipoprotein M is a negative acute response protein that decreases during infection and inflammation |
Human | TREM1 | 54210 | triggering receptor expressed on myeloid cells 1 | During melioidosis, TREM-1 expression is differentially regulated on granulocytes and monocytes; measurement of TREM-1 expression on blood granulocytes may not provide adequate information on granulocyte TREM-1 expression at the infection site Increased TREM-1 expression on monocytes is associated with both infectious and noninfectious inflammatory processes Results show that sTREM-1 and procalcitonin are not specific for infection and can increase markedly in acute inflammation without infection |
Human | TLR9 | 54106 | toll-like receptor 9 | Click here to display 6 evidence detail records. |