Human | PRKAG2 | 51422 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | Identified a novel mutation (Arg531Gly) in the PRKAG2 of AMP-activated protein kinase (AMPK) to be responsible for a syndrome associated with ventricular preexcitation and early onset of atrial fibrillation and conduction disease |
Human | KCNE4 | 23704 | potassium voltage-gated channel, Isk-related family, member 4 | The non-synonymous single nucleotide polymorphism E145D may be associated with the atrial fibrillation phenotype |
Human | KCNE1L | 23630 | KCNE1-like | A missense mutation in KCNE5 may be associated with nonfamilial or acquired forms of atrial fibrillation Title:|Association:Not Found|Conclusion:Not Found |
Human | KCNE3 | 10008 | potassium voltage-gated channel, Isk-related family, member 3 | Abnormalities in the KCNE3 gene is a potential genetic risk factor for initiation and/or maintenance of atrial fibrillation |
Human | KCNE2 | 9992 | potassium voltage-gated channel, Isk-related family, member 2 | KCNE2 R27C is a gain-of-function mutation associated with the initiation and/or maintenance of Atrial Fibrillation |
Human | NUP155 | 9631 | nucleoporin 155kDa | These human and mouse studies indicate that loss of NUP155 function causes atrial fibrillation by altering mRNA and protein transport and link the nuclear pore complex to cardiovascular disease |
Human | ADAM15 | 8751 | ADAM metallopeptidase domain 15 | Atrial fibrillation is associated with an increase in the expression of ADAM15 in the heart atrium |
Human | SLC30A1 | 7779 | solute carrier family 30 (zinc transporter), member 1 | This study provides evidence for increased ZnT-1 expression in atria of patients with atrial fibrillation |
Human | VWF | 7450 | von Willebrand factor | Endothelial dysfunction exists in atrial fibrillation and is related to dysfuncion of VWF levels |
Human | TAC1 | 6863 | tachykinin, precursor 1 | Increase in AngII and decrease in substance P after coronary artery bypass grafting may play role in occurrence of postoperative atrial fibrillation |
Human | STAT3 | 6774 | signal transducer and activator of transcription 3 (acute-phase response factor) | The Ang II/Rac1/STAT3 pathway is an important signaling pathway in the atrial myocardium to mediate atrial structural remodeling, and losartan and statin may be able to reverse Ang II-induced atrial structural remodeling in atrial fibrillation |
Human | SELE | 6401 | selectin E | Endothelial dysfunction exists in atrial fibrillation and is related to dysfuncion of E selectin levels |
Human | SCN5A | 6331 | sodium channel, voltage-gated, type V, alpha subunit | The researchers found a single SCN5A mutation association with arrhythmia in a familial cohort with atrial fibrillation, which suggests this variation in the SCN5A gene is not a significant cause of familial atrial fibrillation SCN5A mutation causes a familial form of atrial fibrillation without any underlying structural heart disease |
Human | RYR2 | 6262 | ryanodine receptor 2 (cardiac) | large genomic deletion in RYR2 leads to extended clinical phenotypes eg, sinoatrial node and atrioventricular node dysfunction, atrial fibrillation, atrial standstill, and dilated cardiomyopathy |
Human | PEPD | 5184 | peptidase D | presence of atrial fibrillation in patients with severe mitral stenosis may be associated with the plasma prolidase activity, tissue and plasma oxidative parameters |
Human | NPPB | 4879 | natriuretic peptide B | BNP levels significantly correlated with atrial fibrillation, indicating that the BNP level may reflect early left ventricular dysfunction in this patient population Data show that brain natriuretic peptide plasma concentrations correlate with the extent of atrial fibrillation-associated silent brain lesions |
Human | NPPA | 4878 | natriuretic peptide A | In a family with 11 members with atrial fibrillation we mapped an atrial fibrillation locus to chromosome 1p36-p35 and identified a heterozygous frameshift mutation in the gene encoding atrial natriuretic peptide |
Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | Title:Angiotensin-converting enzyme and endothelial nitric oxide synthase polymorphisms in patients with atrial fibrillation.|Association:Not Found|Conclusion:The results suggest a possible role of ACE DD genotype as a predisposing factor to AF and a pathophysiological mechanism of ACE inhibition in reducing the incidence of AF in patients with left ventricular dysfunction. |
Human | LMNA | 4000 | lamin A/C | A specific phenotype characterized by early atrial fibrillation is associated with LMNA mutation |
Human | KCNQ1 | 3784 | potassium voltage-gated channel, KQT-like subfamily, member 1 | the S140G mutation in KCNQ1 is likely to initiate and maintain atrial fibrillation by reducing action potential duration and effective refractory period in atrial myocytes no association between atrial fibrillation and single nucleotide polymorphisms Functional assessment of a mutation in Kv7.1 identified in a proband with permanent atrial fibrillation and prolonged QT interval is reported |
Human | KCNJ2 | 3759 | potassium inwardly-rectifying channel, subfamily J, member 2 | Kir2.1 gain-of-function mutation may have a role in development of familial atrial fibrillation |
Human | KCNE1 | 3753 | potassium voltage-gated channel, Isk-related family, member 1 | We report the association between the minK 38G allele and clinical atrial fibrillation no association between atrial fibrillation and single nucleotide polymorphisms |
Human | KCNA5 | 3741 | potassium voltage-gated channel, shaker-related subfamily, member 5 | R87Q and P307S polymorphisms in hKv1.5, possibly in combination with other risk factors, may influencethe development of postoperative atrial fibrillation |
Human | ITGA2 | 3673 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 807C/T polymorphism of glycoprotein Ia (GPIa) gene were associated with higher risk of ischaemic stroke in atrial fibrillation |
Human | IL8 | 3576 | interleukin 8 | Normal levels of C-reactive protein and IL-6, along with the elevated levels of IL-8 in patients with permanent atrial fibrillation (AF), but not in those with paroxysmal AF, suggest a link between a low-grade inflammatory reaction and long-lasting AF |