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Genes (19)
Species: human : 19 | |
Human | ANKH | 56172 | ANKH inorganic pyrophosphate transport regulator | ANKH may be a candidate gene affecting bone size and geometry variation, and thus may be relevant for osteoporosis fracture risk | Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Although adiponectin was a negative determinant of BMD in two independent cohorts, it was not associated with fracture risk in men | Human | PRDM2 | 7799 | PR domain containing 2, with ZNF domain | observed no association of the RIZ1 Pro704 insertion-deletion polymorphism with BMD or fracture risk | Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | VDR genotypes are associated with the risk of fracture in postmenopausal women independently of bone mineral density A Cdx-2 binding site polymorphism (G to A) in the promoter region of the vitamin D receptor gene was reported. investigated the relationship between the VDR Cdx-2 genotype and risk of fracture the common and potentially functional VDR translation start site polymorphism confers a modestly increased relative risk of fracture among older white women | Human | SPP1 | 6696 | secreted phosphoprotein 1 | These are the first data to suggest a role for osteocytes and OPN in the recruitment of mesenchymal stem cells to aid in fracture repair | Human | PTH | 5741 | parathyroid hormone | in a cohort of elderly Swedish women, polymorphisms in PTH may contribute to the risk of fracture through mechanisms that are independent of bone mineral density | Human | TNFRSF11B | 4982 | tumor necrosis factor receptor superfamily, member 11b | Results describe a negative association between serum osteoprotegerin (OPG) and bone mass with increased fracture odds ratios, and an influence of the OPG promoter mutation on bone mass and fracture status independent of serum OPG level Single nucleotide polymorphisms in OPG are not related to bone density or fracture in elderly women We found no significant relationship between sequence variations in the OPG gene or serum OPG and bone mass, bone-related biochemistry or fracture frequency | Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | In this cohort of elderly whites, the MTHFR C677T variant interacts with dietary riboflavin intake to influence fracture risk in women These results indicate that the TT genotype of methylenetetrahydrofolate reductase may be a risk factor for future fracture in addition to the traditional risk factors MTHFR C677T polymorphism is an independent predictor of fracture risk, although it only had a weak effect on bone mineral density | Human | LTBP2 | 4053 | latent transforming growth factor beta binding protein 2 | LTBP2 is a novel positional candidate gene in chromosome 14q quantitative trait locos for bone density variation and fracture | Human | IL1A | 3552 | interleukin 1, alpha | All the polymorphisms within the IL-1alpha gene are in strong linkage disequilibrium and not convincingly associated with fracture risk, BMD, or bone turnover | Human | IGF1 | 3479 | insulin-like growth factor 1 (somatomedin C) | The CA-repeat promoter polymorphism in the IGF-I gene is associated with the risk for fragility fracture at old age in women and with bone structure in both genders | Human | ESR1 | 2099 | estrogen receptor 1 | The ESR1 gene exerts differential genetic effects on bone mineral density and fracture risk | Human | CYP19A1 | 1588 | cytochrome P450, family 19, subfamily A, polypeptide 1 | differences in estrogen levels due to polymorphism at the aromatase CYP19 gene may predispose men to increased age-related bone loss and fracture risk | Human | CTNNB1 | 1499 | catenin (cadherin-associated protein), beta 1, 88kDa | Wnt/beta-catenin signaling mediates the differentiation of osteochondral progenitor cells during fracture repair | Human | COMT | 1312 | catechol-O-methyltransferase | COMT Val158Met polymorphism is associated with fracture risk in elderly men | Human | COL1A1 | 1277 | collagen, type I, alpha 1 | the -1997 G/T and Sp1 polymorphisms in the collagen type I alpha1 (COLIA1) gene may have a role in changes in femoral neck bone mineral density and the risk of fracture in the elderly In a cohort of 75-year-old Swedish women, there was an association among the Sp1 COLIA1 polymorphism, bone mass, and fracture | Human | CLCN7 | 1186 | chloride channel, voltage-sensitive 7 | Autosomal dominant osteopetrosis caused by mutations in the CLCN7 gene is a frequently symptomatic disease manifested by a high rate of fracture, osteomyelitis, visual loss, and occasional bone marrow failure | Human | CDX2 | 1045 | caudal type homeobox 2 | A Cdx-2 binding site polymorphism (G to A) in the promoter region of the vitamin D receptor gene was reported. investigated the relationship between the VDR Cdx-2 genotype and risk of fracture | Human | CASR | 846 | calcium-sensing receptor | Casr polymorphism does not predict serum calcium level, bone density, calcaneal ultrasound indices, or fracture rate in a large cohort of elderly women |
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