Human | PLA2G7 | 7941 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | Title:Vasospastic Angina and Microvascular Angina are Differentially Influenced by PON1 A632G Polymorphism in the Japanese.|Association:Not Found|Conclusion:There was a significant association between PON1 A632G polymorphism and MVA as well as VSA, but the impact of this on VSA and MVA is different in the Japanese. |
Human | TAF1 | 6872 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | Title:Association between thrombin-activatable fibrinolysis inhibitor (TAFI) and clinical outcome in patients with unstable angina pectoris.|Association:Y|Conclusion:In conclusion, in this study population plasma TAFI Ag levels are significantly correlated with refractiveness in patients with UAP. Furthermore, all three polymorphisms contribute independently to plasma TAFI Ag levels, but not to refractiveness. |
Human | PON1 | 5444 | paraoxonase 1 | Title:Vasospastic Angina and Microvascular Angina are Differentially Influenced by PON1 A632G Polymorphism in the Japanese.|Association:Not Found|Conclusion:There was a significant association between PON1 A632G polymorphism and MVA as well as VSA, but the impact of this on VSA and MVA is different in the Japanese. |
Human | PLA2G2A | 5320 | phospholipase A2, group IIA (platelets, synovial fluid) | Data show that serum concentrations of PLA(2)-IIA, Lp(a), ICAM-1 and PECAM-1 are higher for patients with unstable rather that stable angina and controls, and that high plasma Lp(a) is an independent risk factor for angina |
Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | Title:Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) in patients with coexistent hypertrophic cardiomyopathy and coronary spastic angina.|Association:Y|Conclusion:In conclusion, the Asp298 variant of the eNOS gene may be associated with CSA in HCM patients. HCM patients with CSA or the Asp298 variant may need more drugs to relieve their symptoms. |
Human | NFKBIL1 | 4795 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 | no association between polymorphisms and hypertension, myocardial infarct and angina in Irish |
Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Title:The roles of stromelysin-1 and the gelatinase B gene polymorphism in stable angina.|Association:Not Found|Conclusion:Our results show that functional genetic variation of stromelysin-1 could be a significant risk factor for stable angina, and might play an important role in coronary atherosclerosis involving vascular remodeling. |
Human | MMP3 | 4314 | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | Title:The roles of stromelysin-1 and the gelatinase B gene polymorphism in stable angina.|Association:Not Found|Conclusion:Our results show that functional genetic variation of stromelysin-1 could be a significant risk factor for stable angina, and might play an important role in coronary atherosclerosis involving vascular remodeling. |
Human | LTA | 4049 | lymphotoxin alpha | no association between polymorphisms and hypertension, myocardial infarct and angina in Irish |
Human | ITGA3 | 3675 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | Title:Association of genetic polymorphisms in the fibrinogen and platelet glycoprotein genes with unstable angina in Chinese patients|Association:Not Found|Conclusion:Chinese patients with UA had increased frequencies of GP Ib alpha C/B genotype and Bbeta fibrinogen 448A allele. These data suggest that some genetic factors may influence the development of UA. |
Human | GP1BA | 2811 | glycoprotein Ib (platelet), alpha polypeptide | Title:Association of genetic polymorphisms in the fibrinogen and platelet glycoprotein genes with unstable angina in Chinese patients|Association:Y|Conclusion:Chinese patients with UA had increased frequencies of GP Ib alpha C/B genotype and Bbeta fibrinogen 448A allele. These data suggest that some genetic factors may influence the development of UA. |
Human | FGB | 2244 | fibrinogen beta chain | Title:Association of genetic polymorphisms in the fibrinogen and platelet glycoprotein genes with unstable angina in Chinese patients|Association:Y|Conclusion:Chinese patients with UA had increased frequencies of GP Ib alpha C/B genotype and Bbeta fibrinogen 448A allele. These data suggest that some genetic factors may influence the development of UA. |
Human | FGA | 2243 | fibrinogen alpha chain | Title:Association of genetic polymorphisms in the fibrinogen and platelet glycoprotein genes with unstable angina in Chinese patients|Association:Y|Conclusion:Chinese patients with UA had increased frequencies of GP Ib alpha C/B genotype and Bbeta fibrinogen 448A allele. These data suggest that some genetic factors may influence the development of UA. |
Human | ACE | 1636 | angiotensin I converting enzyme | There is an association between the I/D polymorphism of the ACE gene and the presence of fatigue in patients with angina and normal coronary arteriograms |
Human | CYBA | 1535 | cytochrome b-245, alpha polypeptide | Title:Vasospastic Angina and Microvascular Angina are Differentially Influenced by PON1 A632G Polymorphism in the Japanese.|Association:Not Found|Conclusion:There was a significant association between PON1 A632G polymorphism and MVA as well as VSA, but the impact of this on VSA and MVA is different in the Japanese. |
Human | CRP | 1401 | C-reactive protein, pentraxin-related | In cultured PBMC cells from patients with angina, added IFN and CRP further increase TF levels that may contribute to the hypercoagulable state in coronary disease |
Human | CPB2 | 1361 | carboxypeptidase B2 (plasma) | Title:Association between TAFI antigen and Ala147Thr polymorphism of the TAFI gene and the angina pectoris incidence. The PRIME Study (Prospective Epidemiological Study of MI).|Association:Y|Conclusion:Genotyping for the Ala147Thr polymorphism seems to be a reliable tool to assess the risk mediated by TAFI. |
Human | ADRB2 | 154 | adrenoceptor beta 2, surface | Genetic variations of the alpha and beta adrenergic receptors (Beta2 Gln27 allele) were found to be significant predictors of vaospastic angina |