Human | LOC100507436 | 100507436 | | binding of MICA and MICB induces endocytosis and downregulation of NKG2D, and in turn severe impairment of the responsiveness of tumour-antigen-specific effector T cells |
Human | NCF1C | 654817 | neutrophil cytosolic factor 1C pseudogene | The chain of cellular events leading to increased ERK1/2 responsiveness to Ang II in hypertension include an exaggerated response of p47phox |
Human | IL27 | 246778 | interleukin 27 | IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms |
Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | Set/TAF-Ibeta acts as a ligand-activated GR-responsive transcriptional repressor, while Set-Can does not retain physiologic responsiveness to ligand-bound glucocorticoid receptor.[Set-Can fusio protein] |
Human | AMOT | 154796 | angiomotin | PDZ binding motif of angiomotin plays a critical role in regulating the responsiveness of endothelial cells to chemotactic cues |
Human | ABRA | 137735 | actin-binding Rho activating protein | Modulates the responsiveness of the heart to stress signaling by functioning as a cytoskeletal intermediary between human and transgenic myocyte enhancer factor-2 and serum response factor |
Human | TPH2 | 121278 | tryptophan hydroxylase 2 | Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence |
Human | TNFRSF13C | 115650 | tumor necrosis factor receptor superfamily, member 13C | BAFF-R and CD40 enhance B cell responsiveness to transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI)-mediated suppression |
Human | WNT3A | 89780 | wingless-type MMTV integration site family, member 3A | These results suggest that Wnt responsiveness is a stage-specific phenomenon in B-cell development and that the morphological changes associated with Wnt signaling may play a role in the motility and metastatic potential of myeloma cells |
Human | ABCG8 | 64241 | ATP-binding cassette, sub-family G (WHITE), member 8 | Polymorphisms at the half-transporter ABCG5 and ABCG8 genes affect blood cholesterol concentrations in prepubertal children by influencing dietary responsiveness |
Human | SMURF1 | 57154 | SMAD specific E3 ubiquitin protein ligase 1 | LIM-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads |
Human | ACSL5 | 51703 | acyl-CoA synthetase long-chain family member 5 | Existence of a link between ACSL5 genotype and diet responsiveness |
Human | TLR8 | 51311 | toll-like receptor 8 | These data lead us to suggest that ongoing viral activation of TLR7/8 could alter the adaptive immune response by modifying DC differentiation and by down-regulating DC responsiveness to a subsequent bacterial TLR4-mediated signal Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848 |
Human | GP6 | 51206 | glycoprotein VI (platelet) | Induction of GP VI cleavage caused specific down-regulation of collagen-induced platelet aggregation, providing a mechanism for the modulation of platelet responsiveness to this important platelet agonist |
Human | TBX21 | 30009 | T-box 21 | These data suggest that T-bet variation contributes to airway responsiveness in asthma |
Human | CD274 | 29126 | CD274 molecule | Hepatitis c virus-specific CD8 T-cell dysfunction and responsiveness to PD-1/PD-L blockade are defined by their PD-1 expression and compartmentalization |
Human | TBK1 | 29110 | TANK-binding kinase 1 | interferon-A promoter organization differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon |
Human | RNF11 | 26994 | ring finger protein 11 | overexpression of RNF11, through its interaction with Smurf2, can restore TGFbeta responsiveness in transfected tumor cells |
Human | OR1A2 | 26189 | olfactory receptor, family 1, subfamily A, member 2 | Evolutionary conserved amino acid residues to be necessary for specific responsiveness of OR1A1 to odorants were identified |
Human | LY96 | 23643 | lymphocyte antigen 96 | Click here to display 5 evidence detail records. |
Human | KLRK1 | 22914 | killer cell lectin-like receptor subfamily K, member 1 | binding of MICA and MICB induces endocytosis and downregulation of NKG2D, and in turn severe impairment of the responsiveness of tumour-antigen-specific effector T cells |
Human | CD160 | 11126 | CD160 molecule | short-time incubation of NK lymphocytes with IL-15 converts the membrane-bound CD160 to a soluble form; activated NK lymphocytes release a soluble form of CD160 that functionally impairs the MHC-I-specific cytotoxic CD8(+) T lymphocyte responsiveness |
Human | PLAC1 | 10761 | placenta-specific 1 | PLAC1, a trophoblast-specific gene, is Trophoblast-specific expression throughout gestation and responsiveness to KGF are consistent with a fundamental role for PLAC1 at the maternal-fetal interface |
Human | HDAC6 | 10013 | histone deacetylase 6 | HDAC6 mRNA expression may have potential both as a marker of endocrine responsiveness and also as a prognostic indicator in breast cancer |
Human | IKBKE | 9641 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon |