Human | SLC30A8 | 169026 | solute carrier family 30 (zinc transporter), member 8 | The results indicate that in Chinese Hans, common variants in SLC30A8 loci independently or additively contribute to type 2 diabetes risk, likely mediated through beta-cell dysfunction |
Human | CDKAL1 | 54901 | CDK5 regulatory subunit associated protein 1-like 1 | The results indicate that in Chinese Hans, common variants in CDKAL1 loci independently or additively contribute to type 2 diabetes risk, likely mediated through beta-cell dysfunction |
Human | IGF2BP2 | 10644 | insulin-like growth factor 2 mRNA binding protein 2 | The results indicate that in Chinese Hans, common variants in IGF2BP2 loci independently or additively contribute to type 2 diabetes risk, likely mediated through beta-cell dysfunction |
Human | NAMPT | 10135 | nicotinamide phosphoribosyltransferase | change of plasma visfatin concentration by intensive glycemic control may be a compensatory mechanism to ameliorate insulin deficiency due to pancreatic beta-cell dysfunction in type 2 diabetes |
Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Adiponectin concentration is an independent correlate of beta cell function in late pregnancy and may play a key role in mediating insulin resistance and beta cell dysfunction in the pathogenesis of diabetes |
Human | TCF7L2 | 6934 | transcription factor 7-like 2 (T-cell specific, HMG-box) | Odds ratio for single nucleotide polymorphisms associated with plasma proinsulin, beta cell dysfunction and increased risk of type 2 diabettes |
Human | HNF1A | 6927 | HNF1 homeobox A | that beta-cell dysfunction in MODY3 is caused by loss-of-function mechanisms like reduced DNA binding, impaired transcriptional activation, and defects in subcellular localization |
Human | ABCC8 | 6833 | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | |
Human | SREBF1 | 6720 | sterol regulatory element binding transcription factor 1 | Transfected from humans into transgenic mice, SREBP-1c and endogenous lipogenesis could be involved in beta-cell dysfunction and diabetes |
Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | cyclooxygenase-2 has a role in cytokine-induced beta-cell dysfunction and damage Glucose-induced induction of COX-2 in human islets suggest that this is one route through which hyperglycemia may contribute to beta-cell dysfunction |
Human | PAX4 | 5078 | paired box 4 | The Arg121Trp variant in the PAX4 gene is associated with beta cell dysfunction in Japanese subjects with type 2 diabetes. mellitus Beta-cell dysfunction in late-onset diabetic subjects carrying homozygous mutation in transcription factor Pax4 |
Human | NOS1 | 4842 | nitric oxide synthase 1 (neuronal) | Intracellular factors able to induce abnormalities in the nNOS monomer/dimer equilibrium could lead to pancreatic beta-cell dysfunction |
Human | NEUROD1 | 4760 | neuronal differentiation 1 | Beta-cell dysfunction in late-onset diabetic subjects carrying homozygous mutation in transcription factor NeuroD1 |
Human | KCNJ11 | 3767 | potassium inwardly-rectifying channel, subfamily J, member 11 | |
Human | INS | 3630 | insulin | disproportionately elevated proinsulin levels in thalassemic patients indicate early beta-cell dysfunction due to siderosis Fasting intact proinsulin is a suitable measure for beta-cell dysfunction and insulin resistance in type 2 diabetes and may be used to support therapeutic decisions Misfolding leading to impaired endoplasmic reticulum exit of nonmutant proinsulin may be a key early step in a chain reaction of beta cell dysfunction leading to onset and progression of diabetes |
Human | IL1B | 3553 | interleukin 1, beta | These data suggest that glucose- and IL-1beta-induced beta-cell secretory dysfunction and apoptosis are Ca(2+) influx and ERK dependent in rat islets |
Human | HNF4A | 3172 | hepatocyte nuclear factor 4, alpha | The HNF-4alpha clinical phenotype and beta cell dysfunction are similar to HNF-1alpha in maturity onset diabetes in the young |
Human | HHEX | 3087 | hematopoietically expressed homeobox | Single nucleotid polymorphismallele represents a risk allele for beta-cell dysfunction and, mayconfer increased susceptibility of beta-cells toward adverse environmental factors and type 2 diabetes |
Human | GCK | 2645 | glucokinase (hexokinase 4) | Lack of genetic predisposition in offspring to progressive beta cell dysfunction in glucokinase mutation of mmothrs |
Human | CRP | 1401 | C-reactive protein, pentraxin-related | C-reactive protein has a role in advanced stage beta-cell dysfunction and insulin resistance in patients with type 2 diabetes mellitus |
Human | CDKN2B | 1030 | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | The results indicate that in Chinese Hans, common variants in CDKN2B loci independently or additively contribute to type 2 diabetes risk, likely mediated through beta-cell dysfunction |
Human | CDKN2A | 1029 | cyclin-dependent kinase inhibitor 2A | Results indicate that in Chinese Hans, common variants in CDKN2A loci independently or additively contribute to type 2 diabetes risk, likely mediated through beta-cell dysfunction |