Genes (54)
Species: human : 54 | |
Human | UGT1A7 | 54577 | UDP glucuronosyltransferase 1 family, polypeptide A7 | UGT1A7 polymorphisms do not predispose patients to the development of pancreatic cancer and pancreatitis | Human | C18orf8 | 29919 | chromosome 18 open reading frame 8 | Title:Antibody-based approach to high-volume genotyping for MIC-1 polymorphism.|Association:Not Found|Conclusion:This novel antibody-based assay confidently determines the genotype of MIC-1. It offers the advantages of an ELISA-ease of automation, high-volume throughput of samples, and ease of use in a routine, clinical laboratory. | Human | BSCL2 | 26580 | Berardinelli-Seip congenital lipodystrophy 2 (seipin) | | Human | CTRC | 11330 | chymotrypsin C (caldecrin) | Study analyzed the gene encoding the trypsin-degrading enzyme chymotrypsin C in German subjects with idiopathic or hereditary chronic pancreatitis; 2 alterations in this gene were significantly overrepresented in the pancreatitis group | Human | AGPAT2 | 10555 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | | Human | SLC7A7 | 9056 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 | | Human | ST8SIA4 | 7903 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | Pancreatitis risk was highest in individuals with abnormalities in pancreatic duct(CFTR) and acini (PST1) indicating that PST1 is a modifier gene for CFTR-related idiopathic chronic pancreatitis | Human | VEGFA | 7422 | vascular endothelial growth factor A | Title:Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitis.|Association:Not Found|Conclusion:This preliminary study suggests that genetic polymorphism within several cytokine genes is unlikely to influence susceptibility to CP, but the possible role of IL-8 and ICAM-1 polymorphisms in the development of this disease requires further investigation. | Human | TNF | 7124 | tumor necrosis factor | Title:Polymorphism of cytokine genes (TGF-beta1, IFN-gamma, IL-6, IL-10, and TNF-alpha) in patients with chronic pancreatitis.|Association:Not Found|Conclusion:The genotypes corresponding to the high TGF-beta1 producer phenotypes can be associated with the fibrogenesis shown with CP. Title:Analysis of tumor necrosis factor-alpha, transforming growth factor-beta 1, interleukin-10, and interferon-gamma polymorphisms in patients with alcoholic chronic pancreatitis.|Association:Not Found|Conclusion:We did not find an association between the different genotypes and the clinical course of the disease. Therefore, we assume that these genetic variants do not play a dominant role in alcoholic chronic pancreatitis. Title:Polymorphism of the TNF-alpha, HSP70-2, and CD14 genes increases susceptibility to severe acute pancreatitis.|Association:Y|Conclusion:High frequencies of the HSP70-2 G and the TNF-alpha -308 A alleles were associated with risk of severe acute pancreatitis. Genotype assessments may be important prognostic tools to predict disease severity and the course of acute pancreatitis. Therefore, genotype assessments may also be used to guide treatment or to identify risk populations for severe acute pancreatitis. Title:Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitis.|Association:Not Found|Conclusion:This preliminary study suggests that genetic polymorphism within several cytokine genes is unlikely to influence susceptibility to CP, but the possible role of IL-8 and ICAM-1 polymorphisms in the development of this disease requires further investigation. | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | Title:Transforming growth factor-beta1, interleukin-10 and interferon-gamma cytokine polymorphisms in patients with hereditary, familial and sporadic chronic pancreatitis.|Association:Not Found|Conclusion:These genetic variants do not play a dominant role in hereditary, familial or sporadic chronic pancreatitis. Title:Analysis of tumor necrosis factor-alpha, transforming growth factor-beta 1, interleukin-10, and interferon-gamma polymorphisms in patients with alcoholic chronic pancreatitis.|Association:Not Found|Conclusion:We did not find an association between the different genotypes and the clinical course of the disease. Therefore, we assume that these genetic variants do not play a dominant role in alcoholic chronic pancreatitis. Deviation in CD105/TGF-beta ligand complexes suggest that angiogenesis mediated by this complex is not a feature of pancreatitis Polymorphic in pancreatitis Title:Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitis.|Association:Not Found|Conclusion:This preliminary study suggests that genetic polymorphism within several cytokine genes is unlikely to influence susceptibility to CP, but the possible role of IL-8 and ICAM-1 polymorphisms in the development of this disease requires further investigation. Title:Polymorphism of cytokine genes (TGF-beta1, IFN-gamma, IL-6, IL-10, and TNF-alpha) in patients with chronic pancreatitis.|Association:Not Found|Conclusion:The genotypes corresponding to the high TGF-beta1 producer phenotypes can be associated with the fibrogenesis shown with CP. | Human | SPINK1 | 6690 | serine peptidase inhibitor, Kazal type 1 | Click here to display 32 evidence detail records. | Human | SOD2 | 6648 | superoxide dismutase 2, mitochondrial | Title:Genetic polymorphisms of GSTT1, GSTM1, GSTP1, MnSOD, and catalase in nonhereditary chronic pancreatitis: evidence of xenobiotic stress andimpaired antioxidant capacity.|Association:Not Found|Conclusion:We conclude that the GSTT-1 functional genotype is associated with ICP. Evidence of altered glutathione redox status suggests that this disease modification may be a consequence of oxidative stress or the bioactivation of xenobiotics. Title:Association of antioxidant enzyme gene polymorphisms and glutathione status with severe acute pancreatitis|Association:Not Found|Conclusion:The functional GSTT-1*A genotype was associated with severe attacks of pancreatitis. Heightened oxidative stress characterized by glutathione depletion may be of importance in mediating the progression from mild to severe pancreatitis. | Human | CCL2 | 6347 | chemokine (C-C motif) ligand 2 | Title:Is the monocyte chemotactic protein-1 -2518 G allele a risk factor for severe acute pancreatitis?|Association:Not Found|Conclusion:MCP-1 -2518 G allele is a risk factor for severe AP. MCP-1 serum levels, measured early in the course of AP, appear to be an accurate predictor of severity of acute pancreatitis and death. | Human | PRSS1 | 5644 | protease, serine, 1 (trypsin 1) | Click here to display 17 evidence detail records. | Human | PPY | 5539 | pancreatic polypeptide | Pancreatic polypeptide in pancreatitis | Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | Pancreatitis, acute in some | Human | SERPINA1 | 5265 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | study shows no association between cystic fibrosis transmembrane conductance regulator (CFTR) mutations and pancreatitis and the importance of alpha 1-antitrypsin(AAT) variants remains speculative | Human | ATP8B1 | 5205 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | | Human | PCCB | 5096 | propionyl CoA carboxylase, beta polypeptide | | Human | PCCA | 5095 | propionyl CoA carboxylase, alpha polypeptide | | Human | MUT | 4594 | methylmalonyl CoA mutase | | Human | LPL | 4023 | lipoprotein lipase | | Human | LMNA | 4000 | lamin A/C | Pancreatitis, acute in some | Human | KRT8 | 3856 | keratin 8 | KRT8 sequence variants were studied in patients with pancreatitis and pancreatic neoplasms Title:Association of keratin 8 gene mutation with chronic pancreatitis.|Association:Y|Conclusion:G61C mutation of the keratin 8 gene, together with other environmental factors and/or genetic factors, could predispose to chronic pancreatitis, by interfering with the normal organization of keratin filaments. | Human | IL10 | 3586 | interleukin 10 | Title:Polymorphism of cytokine genes (TGF-beta1, IFN-gamma, IL-6, IL-10, and TNF-alpha) in patients with chronic pancreatitis.|Association:Not Found|Conclusion:The genotypes corresponding to the high TGF-beta1 producer phenotypes can be associated with the fibrogenesis shown with CP. Title:Transforming growth factor-beta1, interleukin-10 and interferon-gamma cytokine polymorphisms in patients with hereditary, familial and sporadic chronic pancreatitis.|Association:Not Found|Conclusion:These genetic variants do not play a dominant role in hereditary, familial or sporadic chronic pancreatitis. Title:Analysis of tumor necrosis factor-alpha, transforming growth factor-beta 1, interleukin-10, and interferon-gamma polymorphisms in patients with alcoholic chronic pancreatitis.|Association:Not Found|Conclusion:We did not find an association between the different genotypes and the clinical course of the disease. Therefore, we assume that these genetic variants do not play a dominant role in alcoholic chronic pancreatitis. |
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