Human | NCF1C | 654817 | neutrophil cytosolic factor 1C pseudogene | NAD(P)H oxidase subunits p47(phox) and p67(phox) are expressed in platelets; and NAD(P)H oxidase-dependent platelet superoxide anion release increases platelet recruitment |
Human | BLOC1S3 | 388552 | biogenesis of lysosomal organelles complex-1, subunit 3 | Absent dense bodies in platelets |
Human | PEAR1 | 375033 | platelet endothelial aggregation receptor 1 | C allele of PEAR1 (Platelet endothelial aggregation receptor-1)was generally associated in both ethnic groups with increased aggregation of native platelets |
Human | TREML1 | 340205 | triggering receptor expressed on myeloid cells-like 1 | A soluble fragment of the TLT-1 extracellular domain is found in serum of humans and mice and that an isoform of similar mass is released from platelets following activation with thrombin |
Human | UNC13D | 201294 | unc-13 homolog D (C. elegans) | Rab27 regulates the dense core granule secretion in platelets by employing its binding protein, Munc13-4 |
Human | HPS4 | 89781 | Hermansky-Pudlak syndrome 4 | Absent dense bodies in platelets |
Human | HPS3 | 84343 | Hermansky-Pudlak syndrome 3 | Absent dense bodies in platelets |
Human | DTNBP1 | 84062 | dystrobrevin binding protein 1 | Absent dense bodies in platelets |
Human | JAM3 | 83700 | junctional adhesion molecule 3 | The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1 |
Human | TUBB1 | 81027 | tubulin, beta 1 class VI | The TUBB1 Q43P polymorphism, by causing a lower reactivity in platelets carrying the variant form of b1-tubulin, protects against thrombotic disorders but increases the risk of intracerebral hemorrhage in men |
Human | C6orf25 | 80739 | chromosome 6 open reading frame 25 | G6B represents a novel inhibitory receptor found on the surface of platelets |
Human | HPS6 | 79803 | Hermansky-Pudlak syndrome 6 | Absent dense bodies in platelets |
Human | P2RY12 | 64805 | purinergic receptor P2Y, G-protein coupled, 12 | Click here to display 10 evidence detail records. |
Human | RGS18 | 64407 | regulator of G-protein signaling 18 | molecular cloning and characterization of RGS18 as a regulator of G protein signalling in human platelets |
Human | ADCY10 | 55811 | adenylate cyclase 10 (soluble) | The role of nitric oxide synthase 3 in the activation of soluble guanylyl cyclase in platelets is reported |
Human | CLEC1B | 51266 | C-type lectin domain family 1, member B | platelets capture and transfer infectious HIV-1 via DC-SIGN and CLEC-2, thereby possibly facilitating HIV-1 dissemination in infected patients |
Human | RNF181 | 51255 | ring finger protein 181 | The presence of RN181 in human platelets was established; RN181 has ubiquitin E3 ligase activity |
Human | GP6 | 51206 | glycoprotein VI (platelet) | Click here to display 5 evidence detail records. |
Human | F11R | 50848 | F11 receptor | analysis of F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa in human platelets platelets adhere specifically to F11R of cytokine- (TNF-alpha, INF-gamma) stimulated vascular endothelial cells |
Human | CD209 | 30835 | CD209 molecule | platelets capture and transfer infectious HIV-1 via DC-SIGN and CLEC-2, thereby possibly facilitating HIV-1 dissemination in infected patients |
Human | RAP1GAP2 | 23108 | RAP1 GTPase activating protein 2 | Rap1GAP2 is the first GTPase-activating protein of Rap1 found in platelets and is likely to have an important regulatory role in platelet aggregation |
Human | MMRN1 | 22915 | multimerin 1 | disulfide-linked complexes of multimerin and factor V in platelets could be important for modulating the function of platelet factor V and its delivery onto activated platelets multimerin 1 has a role in delivering and localizing factor V onto platelets prior to prothrombinase assembly |
Human | HPS5 | 11234 | Hermansky-Pudlak syndrome 5 | Absent dense bodies in platelets |
Human | NISCH | 11188 | nischarin | platelets lacked the 170-kD form of IRAS, but 33-kD and 85-kD bands were detectable and seemed to be possible fragments of full-length IRAS |
Human | ADAMTS13 | 11093 | ADAM metallopeptidase with thrombospondin type 1 motif, 13 | Thrombotic microangiopathy (hyaline thrombi of platelets and fibrin in terminal arterioles and capillaries) in type 2B vWD, prolonged lifetimes of vWF bonds with GPIbalpha on circulating platelets may allow ADAMTS-13 to deplete large vWF multimers, causing bleeding |