Human | CCR2 | 729230 | chemokine (C-C motif) receptor 2 | Title:Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1 -2518 G/G genotype in CAD patients.|Association:Y|Conclusion:The MCP-1 -2518G variant in homozygous form appears as a genetic risk factor for severe CAD. This genotype is associated with elevated Lp(a) levels in patients. Individuals homozygous for CCR2-64I or CCR5Delta32 mutations are at reduced risk for severe CAD. |
Human | NCF1C | 654817 | neutrophil cytosolic factor 1C pseudogene | Increased expression and activity of NAD(P)H oxidase subunits and xanthine oxidase, in part mediated through angiotensin II and PKC-dependent pathways, are important mechanisms underlying increased oxidative stress in human coronary artery disease |
Human | IFNE | 338376 | interferon, epsilon | A meta-analysis and a single-nucleotide polymorphism (SNP) rs1333049 representing the 9p21.3 locus provide unprecedented evidence for association between genetic variants at chromosome 9p21.3 and risk of coronary artery disease |
Human | UTS2D | 257313 | | These findings suggest that U-II plays key roles in accelerating the development of atherosclerosis, thereby leading to coronary artery disease |
Human | CAQ14 | 171512 | Circulating adiponectin QTL on chromosome 14 | Male patients with hypoadiponectinemia (<4.0 microg/mL) have a significant 2-fold increase in coronary artery disease (CAD) prevalence, independent of well-known CAD risk factors |
Human | APOA5 | 116519 | apolipoprotein A-V | The present study aimed to elucidate the relationship of four single nucleotide polymorphisms (SNPs) in the Apo11q cluster, to plasma lipids and Coronary Artery Disease effects of APOA5 polymorphisms on plasma triglyceride levels in Turks, a population with low levels of HDL cholesterol and a high prevalence of coronary artery disease no association between APOA5 gene polymorphisms or haplotypes and coronary artery disease as determined by angiography |
Human | P2RY12 | 64805 | purinergic receptor P2Y, G-protein coupled, 12 | There is no association between P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease Gene sequence variations of the P2Y12 receptor gene are associated with the presence of significant coronary artery disease, particularly in non-smoking individuals |
Human | XYLT2 | 64132 | xylosyltransferase II | |
Human | XYLT1 | 64131 | xylosyltransferase I | |
Human | RETN | 56729 | resistin | there was a strong correlation of resistin levels with inflammatory markers suggesting resistin as an inflammatory marker associated with coronary artery disease Serum resistin may prove to be a useful biological marker for coronary artery disease and restenosis in patients with type 2 diabetes mellitus |
Human | SLC2A9 | 56606 | solute carrier family 2 (facilitated glucose transporter), member 9 | common genetic variations within the GLUT9 gene strongly influence the risk for gout but are unlikely to have a major effect on coronary artery disease or myocardial infarct in a German population |
Human | APOM | 55937 | apolipoprotein M | results of the present study suggest that the APOM T-855C polymorphism carries an increased risk for coronary artery disease in this Chinese population The apoM gene is a risk factor for genetic susceptibility to coronary artery disease and is also associated with total cholesterol levels in Han Chinese |
Human | PARL | 55486 | presenilin associated, rhomboid-like | the PARL rs3732581 genetic variant may have a role in insulin levels, metabolic syndrome and coronary artery disease |
Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | data indicate that the preproghrelin Leu72Met polymorphism is not associated with coronary artery disease (CAD) in Chinese population; however, the Leu72Met variant is associated with BMI among CAD patients |
Human | ADIPOR1 | 51094 | adiponectin receptor 1 | Our findings point to genetic variability at the ADIPOR1 locus as a strong determinant of coronary artery disease susceptibility in type 2 diabetes |
Human | C7orf16 | 10842 | | Coronary artery disease presenting after age 30 years in heterozygotes, in childhood in homozygotes |
Human | DHS | 10774 | dehydrated hereditary stomatocytosis | |
Human | KLF2 | 10365 | Kruppel-like factor 2 (lung) | KLF2 expression in circulating monocytes is reduced in patients with chronic inflammatory conditions such as coronary artery disease |
Human | LIPG | 9388 | lipase, endothelial | The endothelial lipase 584C/T allele at codon 111 is associated with protection from coronary artery disease in a Chinese population |
Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Click here to display 11 evidence detail records. |
Human | PLA2G7 | 7941 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | PLA2G7 represents an important, potentially functional candidate in the pathophysiology of coronary artery disease based on replicated associations using two independent datasets and multiple statistical approaches |
Human | WRN | 7486 | Werner syndrome, RecQ helicase-like | C/R polymorphism of WRN does not affect enzyme function or localization and does not influence the incidence of the coronary artery disease |
Human | VTN | 7448 | vitronectin | Plasma vitronectin level potentially represents a pathogenic factor for atherogenesis and thrombus formation in patients with coronary artery disease |
Human | VEGFA | 7422 | vascular endothelial growth factor A | crucial role in the development of coronary artery disease |
Human | VCAM1 | 7412 | vascular cell adhesion molecule 1 | Blood levels do not differ in normal and coronary artery disease patients |