Genes (34)
Species:
human : 34 | |
| Human | NPSR1 | 387129 | neuropeptide S receptor 1 | evidence for a gender-specific effect of Neuropeptide S receptor in the pathogenesis of panic disorder | | Human | DAOAAS | 282706 | | Results suggest that variability of the DAOA/G30 locus may be involved in the etiology of panic disorder | | Human | TPH2 | 121278 | tryptophan hydroxylase 2 | an association with rs1386494 SNP was observed in the subgroup of female patients with pure PD phenotype, indicating a possible gender-specific effect of TPH2 gene variants in panic disorder this first study of TPH2 in panic disorder argue against an importance of allelic variation of TPH2 in the pathogenesis of panic disorder | | Human | GAL | 51083 | galanin/GMAP prepropeptide | polymorphisms in the galanin gene are associated with symptom severity in female patients suffering from panic disorder | | Human | TPH1 | 7166 | tryptophan hydroxylase 1 | Title:Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder.|Association:Not Found|Conclusion:The findings support the hypothesis that comorbid panic disorder identifies a genetic subtype of bipolar disorder and suggest a role for COMT and 5-HTT in vulnerability to these disorders. Title:Associations between serotonin-related gene polymorphisms and panic disorder.|Association:Not Found|Conclusion:These findings indicate that genetic variants conceivably related to lower 5-HT neurotransmission may be involved in the development of PD. | | Human | SLC6A4 | 6532 | solute carrier family 6 (neurotransmitter transporter), member 4 | Title:Association between Serotonin-related Genetic Polymorphisms and CCK-4-induced Panic Attacks with or without 5-hydroxytryptophan Pretreatment in Healthy Volunteers|Association:Not Found|Conclusion:These data suggest that functional genetic polymorphisms of the 5-HT system may influence the vulnerability to panic attacks and add to the growing evidence of inhibitory function of 5-HT in the neuronal circuitry of panic. Title:|Association:Not Found|Conclusion:Not Found Title:Polymorphic MAO-A and 5-HT-transporter genes:analysis of interactions in panic disorder.|Association:Not Found|Conclusion:There was no significant difference in odds ratios, suggesting that the observed increase of genetic liability by the long MAO-A gene promoter allele is not modified by the 5-HTT gene promoter polymorphism. Title:Serotonin gene polymorphisms in patients with panic disorder.|Association:Not Found|Conclusion:The polymorphisms studied were not associated with PD in our population. However, larger patient samples are necessary to confirm or reject these findings. Title:Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder.|Association:Not Found|Conclusion:The findings support the hypothesis that comorbid panic disorder identifies a genetic subtype of bipolar disorder and suggest a role for COMT and 5-HTT in vulnerability to these disorders. Title:Associations between serotonin-related gene polymorphisms and panic disorder.|Association:Not Found|Conclusion:These findings indicate that genetic variants conceivably related to lower 5-HT neurotransmission may be involved in the development of PD. Title:Lack of relationship between CO2 reactivity and serotonin transporter gene regulatory region polymorphism in panic disorder.|Association:Not Found|Conclusion:CO(2) reactivity of patients with panic disorder seems not to be influenced by the genetic variants of the 5-HTTLPR; this finding does not support a role for the serotonin transporter in the etiopathogenesis of CO(2) reactivity in panic disorder. Lack of association between the serotonin transporter promoter polymorphism (5-HTTLPR) and personality traits in asymptomatic patients with panic disorder | | Human | SLC6A2 | 6530 | solute carrier family 6 (neurotransmitter transporter), member 2 | In the subgroup of patients with panic disorder without concurrent agoraphobia, two polymorphisms of the norepinephrine transporter (NET) are found to be associated with the disease | | Human | PGR | 5241 | progesterone receptor | Data suggest that the G331A polymorphism in the progesterone receptor gene may influence the risk for panic disorder in women | | Human | OPRL1 | 4987 | opiate receptor-like 1 | Polymorphism not associated with panic disorder | | Human | NTRK3 | 4916 | neurotrophic tyrosine kinase, receptor, type 3 | Title:5' UTR-region SNP in the NTRK3 gene is associated with panic disorder|Association:Y|Conclusion:None of the polymorphisms in the coding region was significantly associated with panic disorder. | | Human | MAOA | 4128 | monoamine oxidase A | Title:Polymorphic MAO-A and 5-HT-transporter genes:analysis of interactions in panic disorder.|Association:Not Found|Conclusion:There was no significant difference in odds ratios, suggesting that the observed increase of genetic liability by the long MAO-A gene promoter allele is not modified by the 5-HTT gene promoter polymorphism. Title:Associations between serotonin-related gene polymorphisms and panic disorder.|Association:Not Found|Conclusion:These findings indicate that genetic variants conceivably related to lower 5-HT neurotransmission may be involved in the development of PD. Investigation of possible ssociation of a T941G single nucleotide polymorphism with generalized anxiety disorder, panic disorder, or major depression showed an association with gneralized anxiety disorder only Mao-A gene promoter allele was found in panic disorder Title:Association between Serotonin-related Genetic Polymorphisms and CCK-4-induced Panic Attacks with or without 5-hydroxytryptophan Pretreatment in Healthy Volunteers|Association:Y|Conclusion:These data suggest that functional genetic polymorphisms of the 5-HT system may influence the vulnerability to panic attacks and add to the growing evidence of inhibitory function of 5-HT in the neuronal circuitry of panic. | | Human | LDHB | 3945 | lactate dehydrogenase B | Title:Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder.|Association:Not Found|Conclusion:Given the pivotal role of LDH in the metabolism of lactate, a known inducer of panic attacks, and the dependence of LDH activity on cell pH, we suggest that LDHA polymorphisms may contribute to the variability to CO(2) respiratory challenge. | | Human | LDHA | 3939 | lactate dehydrogenase A | an LDHA exon5 haplotype confers increased risk for paradoxically decreased minute volume respiratory response to CO2 challenge but not to panic disorder Title:Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder.|Association:Y|Conclusion:Given the pivotal role of LDH in the metabolism of lactate, a known inducer of panic attacks, and the dependence of LDH activity on cell pH, we suggest that LDHA polymorphisms may contribute to the variability to CO(2) respiratory challenge. | | Human | HTR3A | 3359 | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic | HTR3A may have a role in the personality trait of anxiety, but may not play a major role in the etiology of panic disorder | | Human | HTR2C | 3358 | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | Title:Sex differences in allelic frequencies of the 5-HT2C Cys23Ser polymorphism in psychiatric patients and healthy volunteers: findings from an association study.|Association:Not Found|Conclusion:Not Found Title:Positive association between panic disorder and polymorphism of the serotonin 2A receptor gene|Association:Not Found|Conclusion:The study showed a positive association between panic disorder and the HTR2A gene, suggesting that HTR2A plays an important role in the pathogenesis of panic disorder. | | Human | HTR2A | 3356 | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | Title:Positive association between panic disorder and polymorphism of the serotonin 2A receptor gene|Association:Y|Conclusion:The study showed a positive association between panic disorder and the HTR2A gene, suggesting that HTR2A plays an important role in the pathogenesis of panic disorder. This result suggests that 5HTR2A 1438A/G and 102T/C polymorphic regions can be associated with the phenotype or the pathogenesis of panic disorder Title:Association study of 90 candidate gene polymorphisms in panic disorder.|Association:Not Found|Conclusion:The study results suggest that genetic variants of several candidate genes of neurotransmitter systems, each of a minor individual effect, may contribute to the susceptibility to PD. Our data also indicate that genetic variability may have a distinctive influence on pure and comorbid phenotypes of PD. The study showed a positive association between panic disorder and the HTR2A gene, suggesting that HTR2A plays an important role in the pathogenesis of panic disorder | | Human | HTR1B | 3351 | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | Title:Associations between serotonin-related gene polymorphisms and panic disorder.|Association:Not Found|Conclusion:These findings indicate that genetic variants conceivably related to lower 5-HT neurotransmission may be involved in the development of PD. | | Human | HTR1A | 3350 | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Title:Association of a functional 1019C>G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia.|Association:Y|Conclusion:In conclusion, our findings do not support a major contribution of this polymorphism to the pathogenesis of panic disorder, but provide evidence for a possible role in the subgroup with agoraphobia. Title:Positive association between panic disorder and polymorphism of the serotonin 2A receptor gene|Association:Y|Conclusion:The study showed a positive association between panic disorder and the HTR2A gene, suggesting that HTR2A plays an important role in the pathogenesis of panic disorder. a possible role of 5-HT1A gene polymorphism in the subgroup of panic-disorder patients with agoraphobia In panic disorder patients homozygous for the 5-HT1A-1019G risk allele fearful stimuli were associated with a decreased activation of right prefrontal cortex regions Central 5-HT(1A)receptor binding using positron emission tomography and the selective radioligand 18F]-FCWAY provided evidence for the involvement of 5-HT(1A)receptors in the pathophysiology of panic disorder | | Human | GLO1 | 2739 | glyoxalase I | Title:Association analysis of the functional Ala111Glu polymorphism of the glyoxalase I gene in panic disorder|Association:Not Found|Conclusion:Not Found The present study tested the hypothesis that this common genetic variant could confer susceptibility to panic disorder using an Italian population sample of 162 panic disorder patients and 288 matched controls | | Human | GABRB1 | 2560 | gamma-aminobutyric acid (GABA) A receptor, beta 1 | Title:Exonic variants of the GABA(B) receptor gene and panic disorder.|Association:Not Found|Conclusion:There was no indication of an increased vulnerability to panic disorder or agoraphobia with respect to the allelic variants under study. | | Human | ESR1 | 2099 | estrogen receptor 1 | genetic variants in panic disorder | | Human | ELN | 2006 | elastin | In pedigrees studied, exonic polymorphisms in ELN do not play a major role in the genetic vulnerability to panic disorder | | Human | DRD1 | 1812 | dopamine receptor D1 | Title:Association study of 90 candidate gene polymorphisms in panic disorder.|Association:Not Found|Conclusion:The study results suggest that genetic variants of several candidate genes of neurotransmitter systems, each of a minor individual effect, may contribute to the susceptibility to PD. Our data also indicate that genetic variability may have a distinctive influence on pure and comorbid phenotypes of PD. | | Human | CRHR2 | 1395 | corticotropin releasing hormone receptor 2 | CRHR2 polymorphisms examined do not confer susceptibility to panic disorder | | Human | CRHR1 | 1394 | corticotropin releasing hormone receptor 1 | polymorphisms in the AVPR1B and the CRHR1 genes alter the susceptibility to panic disorder |
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