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Genes (7)
Species:
human : 7 | |
| Human | MIR146A | 406938 | microRNA 146a | breast/ovarian cancer patients with variant C allele miR-146a may have high levels of mature miR-146 and that these variants predispose them to an earlier age of onset of familial breast and ovarian cancers | | Human | FAM175A | 84142 | family with sequence similarity 175, member A | Mutational analysis in 168 multiple-case breast/ovarian cancer families, negative for mutations in BRCA1 or BRCA2, suggests that CCDC98 does not play an important role as a high penetrance breast cancer susceptibility gene | | Human | UIMC1 | 51720 | ubiquitin interaction motif containing 1 | Mutational analysis in 168 multiple-case breast/ovarian cancer families, negative for mutations in BRCA1 or BRCA2, suggests that RAP80 does not play an important role as a high penetrance breast cancer susceptibility gene | | Human | CHEK2 | 11200 | checkpoint kinase 2 | study from South India, on BRCA1, BRCA2 & CHEK2 mutations in patients with a family history of breast and/or ovarian cancer and early onset breast/ovarian cancer | | Human | RNASEL | 6041 | ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) | A silent polymorphism in the RNASEL gene occurs more prevalently in high-risk Ashkenazi breast/ovarian cancer patients without a BRCA1/2 mutation | | Human | BRCA2 | 675 | breast cancer 2, early onset | Cross-sectional analysis of germ-line BRCA2 mutations in Japanese patients suspected to have breast/ovarian cancer is reported Novel germline mutations in BRCA2 gene is associated with hereditary breast and breast-ovarian cancer Study identified a specific spectrum of germline BRCA1/BRCA2 mutations in Portuguese families with inherited predisposition to breast/ovarian cancer and found evidence for genetic anticipation regarding age of diagnosis in succeeding generations No BRCA1/2 genomic rearrangements found in high-risk French-Canadian breast/ovarian cancer families analysis of BRCA1 and BRCA2 mutations in Eastern Finnish breast/ovarian cancer families Findings show that BRCA2 mutations account for a substantial proportion of hereditary breast/ovarian cancer and early-onset breast and ovarian cancer cases in Pakistan Contribution of BRCA2 germline mutations to hereditary breast/ovarian cancer in Germany Novel germline deleterious pathogenic, protein truncating frameshift and non-sense mutations were detected in exon 11 of BRCA2 in breast-ovarian cancer families BRCA2 mutations are associated with breast ans ovarian cancer a total of 287 Greek breast/ovarian cancer families, 46 and 13 carry a deleterious mutation in BRCA1 and BRCA2, respectively In a population well beyond the average age of breast/ovarian cancer onset, 21 different sequence variants in the BRCA1 gene (one novel) and 36 variants in the BRCA2 gene (7 novel) were detected findings show that BRCA mutations account for a substantial proportion of hereditary breast/ovarian cancer in Colombia study from South India, on BRCA1, BRCA2 & CHEK2 mutations in patients with a family history of breast and/or ovarian cancer and early onset breast/ovarian cancer | | Human | BRCA1 | 672 | breast cancer 1, early onset | analysis of BRCA1 disease-associated haplotypes in Singapore Malay women with early-onset breast/ovarian cancer data showed high prevalence of BRCA1 gene mutation among breast or breast/ovarian cancer families in South India and breast cancer patients having BRCA1 mutations were associated with poor prognosis BRCA1 mutations are associated with breast ans ovarian cancer analysis of BRCA1 and BRCA2 mutations in Eastern Finnish breast/ovarian cancer families findings show that BRCA mutations account for a substantial proportion of hereditary breast/ovarian cancer in Colombia BRCA1 is a tumor suppressor gene and is known to be responsible for breast cancer and breast-ovarian cancers running in families Cross-sectional analysis of germ-line BRCA1 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer is reported Findings show that BRCA1 mutations account for a substantial proportion of hereditary breast/ovarian cancer and early-onset breast and ovarian cancer cases in Pakistan Novel germline deleterious pathogenic, protein truncating frameshift and non-sense mutations were detected in exon 2, exon 11 of BRCA1 in breast-ovarian cancer families study from South India, on BRCA1, BRCA2 & CHEK2 mutations in patients with a family history of breast and/or ovarian cancer and early onset breast/ovarian cancer analysis of BRCA1 gene was carried out in 56 Slovak breast/ovarian cancer families; 4 mutations accounted for 61.3% of all detected pathogenic mutations in BRCA1, and there also was a large scale of low frequency disease causing mutations two BRCA1 mutations, 5382insC and G1738R, both located in exon 20, account for 46% of the families found to carry a mutation in Greek breast/ovarian cancer families |
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