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Genes (25)
Species: human : 25 | |
Human | LRRK2 | 120892 | leucine-rich repeat kinase 2 | Data show that the proportion of LRRK2-immunopositive glial cytoplasmic inclusions is negatively associated with an increase in neuronal loss and alpha-synuclein-immunopositive dystrophic axons in multiple system atrophy Neuronal loss in the substantia nigra | Human | SLC17A7 | 57030 | solute carrier family 17 (vesicular glutamate transporter), member 7 | Alterations in the pattern of vesicular glutamate transporter 1-immunoreactivity that perfectly matched the neuronal loss and gliosis, as well as the decrease in the number of asymmetrical synapses identified by electron microscopy in this tissue | Human | SCO2 | 9997 | SCO2 cytochrome c oxidase assembly protein | Gliosis, necrosis, neuronal loss in basal ganglia, brainstem, and spinal cord | Human | PLA2G6 | 8398 | phospholipase A2, group VI (cytosolic, calcium-independent) | | Human | TP53 | 7157 | tumor protein p53 | oxidative modification of p53 could be involved in the neuronal loss observed in neurodegenerative conditions | Human | TIMP3 | 7078 | TIMP metallopeptidase inhibitor 3 | TIMP-3 is an upstream mediator of neuronal apoptosis and likely contributes to neuronal loss in neurodegenerative diseases such as amyotrophic lateral sclerosis | Human | TBP | 6908 | TATA box binding protein | Neuronal loss in the striatum, medial thalamic nuclei, and inferior olives | Human | SNCA | 6622 | synuclein, alpha (non A4 component of amyloid precursor) | A correlation study indicated a close relationship among decreased TH immunoreactivity, alphaS accumulation, and neuronal loss Parkinsonian brains directed expression of the molecular chaperone Hsp70 prevented dopaminergic neuronal loss associated with alpha-synuclein in Drosophila model of Parkinson's disease | Human | PVALB | 5816 | parvalbumin | There is no correlation between total neuronal loss and PV-ir neuronal loss in any of the hippocampal fields in epileptic patient | Human | PSEN1 | 5663 | presenilin 1 | Cortical and subcortical neuronal loss in the frontal and temporal regions | Human | PSAP | 5660 | prosaposin | | Human | PRNP | 5621 | prion protein | Brainstem may show neuronal loss Thalamic neuronal loss, especially in the medial dorsal nucleus | Human | POLG | 5428 | polymerase (DNA directed), gamma | | Human | SERPINI1 | 5274 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | | Human | PC | 5091 | pyruvate carboxylase | Neuronal loss in the cerebral cortex | Human | PARK2 | 5071 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | Neuronal loss and gliosis in the substantia nigra pars compacta Neuronal loss in the locus ceruleus | Human | MAPT | 4137 | microtubule-associated protein tau | Neuropathology shows neuronal loss in basal ganglia, brainstem, and cerebellum Cortical and subcortical neuronal loss in the frontal and temporal regions Data demonstrate that aged (>20 months old) mice expressing wild-type human tau display impaired place learning and memory, even though they do not form neurofibrillary tangles or display neuronal loss Suppressing the transgene (tau)prevented further neuronal loss without removing or preventing additional accumulation of neurofibrillary pathology Expression levels of misfolded truncated tau determine life span in transgenic rat model of tauopathy without causing neuronal loss or correlating with terminal neurofibrillary tangle load | Human | LGALS1 | 3956 | lectin, galactoside-binding, soluble, 1 | galectin-1 induces astrocyte differentiation and strongly inhibits astrocyte proliferation, and then the differentiated astrocytes greatly enhance their production of BDNF which may be a new mechanism for preventing neuronal loss after injury | Human | GRM3 | 2913 | glutamate receptor, metabotropic 3 | Reduction of mGluR3 immunopositive product in the stratum lacunosum moleculare of hippocampal CA1 is a consequence of neuronal loss in either the entorhinal cortex or CA1 area of the hippocampus | Human | GRM2 | 2912 | glutamate receptor, metabotropic 2 | Reduction of mGluR2 immunopositive product in the stratum lacunosum moleculare of hippocampal CA1 is a consequence of neuronal loss in either the entorhinal cortex or CA1 area of the hippocampus | Human | GRN | 2896 | granulin | Cortical and brainstem neuronal loss | Human | CTSD | 1509 | cathepsin D | Neuronal loss in the cerebrum and cerebellum | Human | FASLG | 356 | Fas ligand (TNF superfamily, member 6) | Fas-FasL interactions may contribute to mechanisms of neuronal loss and neuritic degeneration in Alzheimer disease | Human | APP | 351 | amyloid beta (A4) precursor protein | complexed with acetylcholinesterase, is toxic to rat brain beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss | Human | ACHE | 43 | acetylcholinesterase | complexed with abeta protein, is toxic to rat brain beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss |
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