Human | PDSS2 | 57107 | prenyl (decaprenyl) diphosphate synthase, subunit 2 | |
Human | ADCK3 | 56997 | aarF domain containing kinase 3 | |
Human | RETN | 56729 | resistin | Resistin promotes lipid accumulation in human macrophages through its upregulating CD36 cell surface expression |
Human | APTX | 54840 | aprataxin | |
Human | COQ2 | 27235 | coenzyme Q2 4-hydroxybenzoate polyprenyltransferase | |
Human | PDSS1 | 23590 | prenyl (decaprenyl) diphosphate synthase, subunit 1 | |
Human | NR1H3 | 10062 | nuclear receptor subfamily 1, group H, member 3 | activation of the liver X receptors (LXR) dramatically promoted lipid accumulation in vascular smooth muscle cells |
Human | ABCG1 | 9619 | ATP-binding cassette, sub-family G (WHITE), member 1 | Macrophage ABCG1 deficiency does lead to heavy lipid accumulation in macrophages of the lung, and also a moderately significant effect on atherosclerotic lesion development was observed |
Human | PLA2G10 | 8399 | phospholipase A2, group X | This study showed that GX sPLA2 is present in human atherosclerotic lesions and that the hydrolysis of LDL cholesterol by GX sPLA2 results in a modified particle that induces lipid accumulation in human monocyte-derived macrophages secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology |
Human | VIM | 7431 | vimentin | Endosomal lipid accumulation in Niemann-Pick type C1 disease leads to inhibition of protein kinase C, hypophosphorylation of vimentin and Rab9 entrapment |
Human | NR1H2 | 7376 | nuclear receptor subfamily 1, group H, member 2 | activation of the liver X receptors (LXR) dramatically promoted lipid accumulation in vascular smooth muscle cells |
Human | SNCA | 6622 | synuclein, alpha (non A4 component of amyloid precursor) | when expressed in yeast, it associated with the plasma membrane in a highly selective manner, before forming cytoplasmic inclusions; inhibited phospholipase D, induced lipid droplet accumulation, and affected vesicle trafficking |
Human | SFTPD | 6441 | surfactant protein D | Intrapulmonary administration of a truncated 60-kDa fragment of human recombinant SP-D into SP-D-deficient mice reduces the number of apoptotic and necrotic alveolar macrophages and partially corrects the lipid accumulation |
Human | PPARA | 5465 | peroxisome proliferator-activated receptor alpha | Transgenic mice with cardiac-restricted overexpression of PPAR alpha exhibit myocyte lipid accumulation and cardiac dysfunction |
Human | MSR1 | 4481 | macrophage scavenger receptor 1 | PAF enhances its own receptor expression and then increases lipid accumulation by dysregulating LDL receptor regulation and inducing scavenger receptor expression in mesangial cells |
Human | LDLR | 3949 | low density lipoprotein receptor | PAF enhances its own receptor expression and then increases lipid accumulation by dysregulating LDL receptor regulation and inducing scavenger receptor expression in mesangial cells |
Human | IL8 | 3576 | interleukin 8 | These data demonstrate for the first time that lipid accumulation in hepatocytes can stimulate IL-8 production, thereby potentially contributing to hepatic inflammation and consequent liver injury |
Human | IGF1 | 3479 | insulin-like growth factor 1 (somatomedin C) | IGF-I may play a critical role in adipocyte differentiation and lipid accumulation |
Human | CXCL1 | 2919 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | GROalpha could be involved in atherogenesis and plaque destabilization, potentially contributing to inflammation, matrix degradation, and lipid accumulation within the atherosclerotic lesion |
Human | GFPT1 | 2673 | glutamine--fructose-6-phosphate transaminase 1 | two polymorphisms in the 5'-flanking region of GFAT, of which the -913 polymorphism seems to alter the risk for obesity and intramyocellular lipid accumulation in male subjects |
Human | SLC25A10 | 1468 | solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 | Slc25a10 plays an important role in supplying malate for citrate transport required for fatty acid synthesis and its inhibition might effectively reduce lipid accumulation in adipose tissues |
Human | CPT2 | 1376 | carnitine palmitoyltransferase 2 | Lipid accumulation in skeletal muscle Lipid accumulation in heart Lipid accumulation in hepatocytes Lipid accumulation in kidney, especially in proximal convoluted tubules |
Human | BHMT | 635 | betaine--homocysteine S-methyltransferase | The BHMT/betaine system directly protects hepatocytes from homocysteine-induced injury but not tunicamycin-induced injury, including an endoplasmic reticulum stress response, lipid accumulation, and cell death |
Human | APOE | 348 | apolipoprotein E | These findings show that oxidation of chylomicron-remnant-like particles lowers their rate of uptake and induction of lipid accumulation in macrophages |