Debug Stats | ### Total Build Time: 27 ms 33.427 KB CONCEPT_NAME gt=11 ms Completed: 11 ms rowSize= 360 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 208 bytes- Skipping details on:
CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes - Skipping details on:
CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes- Skipping details on:
CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytesCONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytesCONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytesCONCEPT_RELATIONSHIPS gt=6 ms Completed: 6 ms rowSize= 15.259 KBCONCEPT_GENES gt=6 ms Completed: 6 ms rowSize= 16.378 KBCONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.165 KBCONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes- Reload Stats
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Relationships (35)
Relation Types: diso_to_anat : 21 diso_to_diso : 14
Relationships: associated_with : 1 is_abnormal_cell_of_disease : 7 is_associated_disease_of : 3 is_finding_of_disease : 2 is_normal_cell_origin_of_disease : 5 is_normal_tissue_origin_of_disease : 2 is_not_abnormal_cell_of_disease : 2 is_not_normal_cell_origin_of_disease : 3 is_primary_anatomic_site_of_disease : 2 isa : 1 may_be_associated_disease_of_disease : 1 may_be_cytogenetic_abnormality_of_disease : 3 may_be_finding_of_disease : 3 | |
DISO_to_ANAT | | is_abnormal_cell_of_disease |
Atypical lymphocyte C0221277 | DISO_to_ANAT | | is_not_normal_cell_origin_of_disease |
B lymphoblast C1516097 | DISO_to_ANAT | | is_normal_cell_origin_of_disease |
B-Lymphocytes C0004561 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Cancer Cell C0334227 | DISO_to_ANAT | | is_not_abnormal_cell_of_disease |
Cells, Reed-Sternberg C0085133 | DISO_to_ANAT | | is_normal_cell_origin_of_disease |
Germinal Center B-Lymphocyte C1517532 | DISO_to_ANAT | | is_normal_tissue_origin_of_disease |
HEMOLYMPHORETICULAR TISSUE C1512398 | DISO_to_ANAT | | is_primary_anatomic_site_of_disease |
Hematopoietic and Lymphatic System C1512394 | DISO_to_ANAT | | is_normal_cell_origin_of_disease |
Hematopoietic and Lymphoid Cell C1512385 | DISO_to_ANAT | | is_primary_anatomic_site_of_disease |
Lymphatic System C0024235 | DISO_to_ANAT | | is_normal_tissue_origin_of_disease |
Lymphatic Tissue C0024296 | DISO_to_ANAT | | is_normal_cell_origin_of_disease |
Lymphocyte C0024264 | DISO_to_ANAT | | is_normal_cell_origin_of_disease |
Mature B-Cell C1513019 | DISO_to_ANAT | | is_not_normal_cell_origin_of_disease |
Myeloid Cells C0887899 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic B-Lymphocyte C1513929 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Cell C0597032 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Hematopoietic and Lymphoid Cell C1513983 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Lymphocyte C1514011 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Medium-Sized B-Lymphocyte with Basophilic Cytoplasm C1513065 | DISO_to_ANAT | | is_not_abnormal_cell_of_disease |
Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell C1514110 | DISO_to_ANAT | | is_not_normal_cell_origin_of_disease |
Plasma Cells C0032112 | DISO_to_DISO | | isa |
AIDS-Related Burkitt Lymphoma with Plasmacytoid Differentiation C1336922 | DISO_to_DISO | | associated_with |
Acquired Immunodeficiency Syndrome C0001175 | DISO_to_DISO | | may_be_finding_of_disease |
Aggressive Clinical Course C1332223 | DISO_to_DISO | | may_be_finding_of_disease |
Bulky Disease C1511341 |
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Genes (8)
Species: human : 8 | |
Human | ERVK7 | 449619 | | Here, we examined Old World primate species for the presence of full-length HERV-K gag and env genes and the presence of gag and env open reading frames as determined by the protein truncation test. | Human | ERVK6 | 64006 | | A group of human endogenous retroviruses, HERV-K, which is related to the mouse mammary tumour virus, has been characterised previously and open reading frames have been found covering their gag, pol, prt and env genes. Here, we examined Old World primate species for the presence of full-length HERV-K gag and env genes and the presence of gag and env open reading frames as determined by the protein truncation test. Here, we set out to determine the chromosomal distribution of full-length HERV-K env genes. By in situ hybridization using four non-overlapping, isotopically labeled RNA probes specific for HERV-K gag and env sequences on archival tissue samples, consistent HERV-K expression of gag and env genes was found to be common to all GCTs and their testicular precursor lesions with the exception of teratomas, mature and immature, and spermatocytic seminomas. Two types of HERV-K genomes exist which differ in the absence (type 1) or the presence (type 2) of a sequence of 292 nucleotides between the putative pol and env genes. | Human | LOR | 4014 | loricrin | In addition to containing the gag, pol, and env genes of the chronic leukemia viruses, the genome of HTLV-I contains a long open reading frame (LOR) located between the 3; end of the envelope gene and the 3; long terminal repeat sequence (LTR). | Human | IL16 | 3603 | interleukin 16 | Studying a panel of human B-cell lines derived from patients with Burkitt;s lymphoma (BL) and AIDS-associated Burkitt;s lymphoma (AIDS-BL) we had described constitutive expression and secretion of large amounts of Interleukin-16 (IL-16), Macrophage Inflammatory Protein-1alpha (MIP-1alpha), Macrophage Inflammatory Protein-1beta (MIP-1beta), Interleukin-12 (IL-12), Interleukin-10 (IL-10), and Interleukin-7 (IL-7). | Human | ERVK3 | 2088 | | Two types of HERV-K genomes exist which differ in the absence (type 1) or the presence (type 2) of a sequence of 292 nucleotides between the putative pol and env genes. | Human | ERVK2 | 2087 | | A group of human endogenous retroviruses, HERV-K, which is related to the mouse mammary tumour virus, has been characterised previously and open reading frames have been found covering their gag, pol, prt and env genes. Here, we examined Old World primate species for the presence of full-length HERV-K gag and env genes and the presence of gag and env open reading frames as determined by the protein truncation test. The strongest sequence homologies were found in comparison to human endogenous retrovirus (HERV-K): between 65-88% for gag, pol and env genes. By in situ hybridization using four non-overlapping, isotopically labeled RNA probes specific for HERV-K gag and env sequences on archival tissue samples, consistent HERV-K expression of gag and env genes was found to be common to all GCTs and their testicular precursor lesions with the exception of teratomas, mature and immature, and spermatocytic seminomas. HERV-K is the most biologically active form, since members of this family have intact open reading frames for the gag, pol or env genes. Two types of HERV-K genomes exist which differ in the absence (type 1) or the presence (type 2) of a sequence of 292 nucleotides between the putative pol and env genes. | Human | CCR5 | 1234 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | Site-directed mutagenesis of multiple primary and prototypic R5 env genes demonstrated that the GPG motif was necessary for dual utilization of the N terminus and body of CCR5 in both gain and loss-of-function experiments. | Human | CD151 | 977 | CD151 molecule (Raph blood group) | Expression of the wild-type and mutant env genes from a simian virus 40-based vector resulted in normal biosynthesis and processing of the glycoproteins to gp130 and gp41 or the truncated TM proteins (gp28 and gp27). |
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