Human | VKORC1 | 79001 | vitamin K epoxide reductase complex, subunit 1 | No clear link waqs found between VKORC1 genetic polymorphism and the risk of venous thrombosis or peripheral arterial disease |
Human | P2RY12 | 64805 | purinergic receptor P2Y, G-protein coupled, 12 | a P2Y12 34C>T polymorphism may have a role in development of ischemic cerebrovascular events in patients with peripheral artery disease Title:P2Y12 H2 haplotype is associated with peripheral arterial disease: a case-control study.|Association:Y|Conclusion:These data point to a role of the H2 haplotype in atherosclerosis and raise the possibility of relative thienopyridine resistance in carriers of the P2Y12 H2 haplotype. |
Human | UGT1A1 | 54658 | UDP glucuronosyltransferase 1 family, polypeptide A1 | This study of patients with intermittent claudication and control individuals revealed a clear association between low bilirubin concentrations and peripheral arterial disease but no association between the UGT1A1 polymorphism and the disease |
Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | adiponectin and amino terminal natriuretic peptide precursor B were related to disease severity, indicating a possible role for assessment of future morbidity and mortality in patients with peripheral arterial disease |
Human | VCAM1 | 7412 | vascular cell adhesion molecule 1 | higher sICAM-1 and sVCAM-1 concentrations were independently associated with lower ankle-brachial index and peripheral arterial disease in blacks, but not in non-Hispanic whites |
Human | SPP1 | 6696 | secreted phosphoprotein 1 | Osteopontin levels are elevated in patients with peripheral arterial disease |
Human | CCL2 | 6347 | chemokine (C-C motif) ligand 2 | Elevation of MCP-1 in the circulation of peripheral arterial disease(PAD) patients implicates this CC chemokine ligand 2 in inflammatory processes contributing to PAD clinical symptomatology |
Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | The Ala12 allele of PPAR-gamma2 is associated with lower levels of soluble RAGE and the presence of peripheral arterial disease |
Human | PLTP | 5360 | phospholipid transfer protein | in non-diabetic, non-smoking subjects low rather than high PLTP activity is a marker for the presence of peripheral arterial disease |
Human | ENPP1 | 5167 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | Report association between K121Q polymorphism of ENPP1 and peripheral arterial disease |
Human | NPPB | 4879 | natriuretic peptide B | adiponectin and NT-proBNP were related to disease severity, indicating a possible role for assessment of future morbidity and mortality in patients with peripheral arterial disease |
Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | specific NOS3 SNPs and haplotypes were associated with inter-individual variation in ankle brachial index, a non-invasive marker of peripheral arterial disease, in replicate subsets of hypertensive subjects |
Human | MTTP | 4547 | microsomal triglyceride transfer protein | The (-)493TT single nucleotide polymorphism in the microsomal triglyceride transfer protein (MTP) promoter region is associated with altered lipoprotein levels and with presence of peripheral arterial disease (PAD) |
Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | genetic influence of the methylenetetrahydrofolate reductase (MTHFR) 677C>T genotype on diabetic peripheral arterial disease is modest, yet for the Oji-Cree it is a major risk factor |
Human | LPA | 4018 | lipoprotein, Lp(a) | study shows that the 93T allele of the LPA gene is associated with a reduced risk of peripheral arterial disease and low Lp(a) levels |
Human | LIPC | 3990 | lipase, hepatic | Patients with type 2 diabetes who are carriers of the rare -250A allele in the promoter of the hepatic lipase gene are susceptible to peripheral arterial disease |
Human | ICAM1 | 3383 | intercellular adhesion molecule 1 | higher sICAM-1 and sVCAM-1 concentrations were independently associated with lower ankle-brachial index and peripheral arterial disease in blacks, but not in non-Hispanic whites |
Human | HFE | 3077 | hemochromatosis | case control study shows no association between HFE polymorphisms and peripheral artery disease |
Human | SERPIND1 | 3053 | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | after receiving stent for peripheral artery disease, patients with a high HCII activity had a 0.39-fold reduced risk for instent restenosis |
Human | GGT1 | 2678 | gamma-glutamyltransferase 1 | There was a positive association between serum GGT level and peripheral artery disease among men, particularly non-Hispanic white and nondrinker men, but not among women |
Human | F7 | 2155 | coagulation factor VII (serum prothrombin conversion accelerator) | the 2 adenine insertion in the 3'UTR of FVII gene, related to lower plasma FVII levels, is a genetic variation that may contribute to reduce the risk of peripheral arterial disease |
Human | F5 | 2153 | coagulation factor V (proaccelerin, labile factor) | factor II G20210A gene polymorphism, but not factor V Arg506Gln, may have a role in peripheral arterial disease |
Human | F2 | 2147 | coagulation factor II (thrombin) | factor II G20210A gene polymorphism, but not factor V Arg506Gln, may have a role in peripheral arterial disease |
Human | ACE | 1636 | angiotensin I converting enzyme | ACE I/D polymorphism is not a significant risk factor for peripheral arterial disease |
Human | CX3CR1 | 1524 | chemokine (C-X3-C motif) receptor 1 | a difference in genotype frequencies of the V249I and T280M polymorphisms in CX(3)CR1 between peripheral arterial disease patients and controls could not be detected |