Human | VIM | 7431 | vimentin | vimentin expression contributes to the invasive phenotype in androgen-independent prostate cancer but cannot confer it alone |
Human | TWIST1 | 7291 | twist basic helix-loop-helix transcription factor 1 | Results have identified TWIST as a critical regulator of prostate cancer cell growth and suggest a potential therapeutic approach to inhibit the growth and metastasis of androgen-independent prostate cancer through inactivation of the TWIST gene |
Human | TRPS1 | 7227 | trichorhinophalangeal syndrome I | suggests a possible involvement of TRPS1 in oxidative stress, and possibly in apoptosis in androgen-independent DU145 prostate cancer cells |
Human | PTK2 | 5747 | protein tyrosine kinase 2 | The interplay between FAK and ERK in androgen-independent prostate cancer cells (PC3 and DU145 cells), was investigated |
Human | PTEN | 5728 | phosphatase and tensin homolog | Pten inactivation has a role in emergence of androgen-independent prostate cancer [review] |
Human | PSAP | 5660 | prosaposin | Cloning of prosaposin gene from androgen-independent (AI) prostate cancer (PCa) cells and it genomic amplification in human metastatic AI PCa cell lines and punch biopsy samples of prostate cancer xenografts and lymph node metastases |
Human | PRKCZ | 5590 | protein kinase C, zeta | Protein kinase Czeta/mammalian target of rapamycin/S6 kinase pathway plays an important role for the transition of androgen-dependent to androgen-independent prostate cancer cells |
Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | Peroxisome proliferator-activated receptor-gamma is frequently over-expressed in androgen independent prostate cancer cell lines and human prostate cancer tissues |
Human | PIK3CG | 5294 | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma | IL-4 > PI3K/Akt > NF-(kappa)B signaling pathways, which activate androgen receptor signaling, play an important role during the development of androgen independent prostate cancer cells |
Human | ABCB1 | 5243 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | negative implications for docetaxel treatment in androgen-independent prostate cancer patients carrying ABCB1 variant genotypes |
Human | NFKB1 | 4790 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | IL-4 > PI3K/Akt > NF-(kappa)B signaling pathways, which activate abdrogen receptor signaling, play an important role during the development of androgen independent prostate cancer cells |
Human | LEP | 3952 | leptin | il-6 and ILGF1 demonstrate additive and synergistic effects on leptin stimulation of androgen-independent prostate cancer cell proliferation, demonstrating that adipose cytokines are key mediators between obesity and hormone-resistant prostate cancer |
Human | IL8 | 3576 | interleukin 8 | IL-8 is a molecular determinant of androgen-independent prostate cancer growth and progression |
Human | IL4 | 3565 | interleukin 4 | IL-4 plays an important role in promoting androgen-independent prostate cancer growth |
Human | GSTP1 | 2950 | glutathione S-transferase pi 1 | GST-pi might play important roles in proliferation of androgen-independent human prostate cancer cells |
Human | SFN | 2810 | stratifin | Expression level of 14-3-3sigma in androgen-independent prostate cancer cell lines DU145, PC3, and CWR22RV are much higher than that in the androgen-dependent cell line LNCaP |
Human | GLO1 | 2739 | glyoxalase I | In androgen-dependent and androgen-independent prostate cancer cells, testosterone upregulates GLO1 mRNA levels |
Human | EGFR | 1956 | epidermal growth factor receptor | The Id-1-induced androgen-independent prostate cancer cell growth was correlated with up-regulation of EGF-R |
Human | CYP17A1 | 1586 | cytochrome P450, family 17, subfamily A, polypeptide 1 | results suggest that the CYP17 polymorphism (-34T>C) is associated with overall survival in patients with androgen-independent prostate cancer |
Human | CRP | 1401 | C-reactive protein, pentraxin-related | Elevated plasma C-reactive protein is associated with androgen-independent prostate cancer |
Human | CDK1 | 983 | cyclin-dependent kinase 1 | increased Cdk1 activity is a mechanism for increasing androgen receptor expression and stability in response to low androgen levels in androgen-independent prostate cancer |
Human | AR | 367 | androgen receptor | intracellular control of AR expression levels through the natural AR promoter might be needed for determining AR function in androgen-independent prostate cancer (AIPC) PC-3 cells Title:Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663.|Association:Not Found|Conclusion:These data suggest that AR mutations are present in approximately 10% of patients with prostate cancer who experience treatment failure with hormone therapy that included an antiandrogen. Mutations in the AR likely confer a growth advantage for a subset of progressive prostate cancers. Correlation of AR mutation with antiandrogen withdrawal response or survival could not be made. Inhibition by pomegranate polyphenols of gene expression involved in androgen-synthesizing enzymes and the androgen receptors may be of particular importance in androgen-independent prostate cancer cells AR is controlled by a suppressor complex lost in an androgen-independent prostate cancer cell line increased cyclin-dependent kinase 1 activity is a mechanism for increasing AR expression and stability in response to low androgen levels in androgen-independent prostate cancer |
Human | KLK3 | 354 | kallikrein-related peptidase 3 | NF-kappa B activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer |