Genes (55)
Species: human : 55 | |
Human | PDIA6 | 10130 | protein disulfide isomerase family A, member 6 | ERP5 regulates the binding of fibrinogen, cell-surface exposure of P-selectin, and coassociation of beta 3 integrin in stimulated platelets | Human | VWF | 7450 | von Willebrand factor | VWF and fibrinogen are differentially packaged in human platelets | Human | VCL | 7414 | vinculin | vinculin is tyrosine phosphorylated in platelets spread on fibrinogen, and the phosphorylation is Src kinases dependent | Human | TNF | 7124 | tumor necrosis factor | Inflammatory markers associated with the acute-phase response (IL-6, TNF-alpha, C-reactive protein, and fibrinogen, but not IL-18) are associated with risk of recurrent stroke The inflammatory markers, hsCRP, ESR, WBC, fibrinogen, and TNF-alpha, were raised in all patients but were significantly higher in rheumatoid arthritis patients with coronary artery disease who also had periodontal disease | Human | TMSB4X | 7114 | thymosin beta 4, X-linked | activated factor XIII incorporates thymosin beta(4) into the isolated gamma-module and alphaC-domain (fibrinogen A alpha); in fibrin the latter serves as the major incorporation site | Human | TLR4 | 7099 | toll-like receptor 4 | Fibrinogen alone and fibrinogen plus C5a are potent inducers of IL-8 production in monocytes, and signaling by fibrinogen is mediated through the TLR-4 pathway fibrinogen activates TLR4, explaining how fibrinogen promotes inflammatory protein expression | Human | STAT3 | 6774 | signal transducer and activator of transcription 3 (acute-phase response factor) | Stat3 is transactivated via IL-6 response elements on fibrinogen promoters with participation of additional transcription factors | Human | SPARC | 6678 | secreted protein, acidic, cysteine-rich (osteonectin) | Data show that SPARC binds to plasmin-cleaved fibrinogen, but not to native fibrinogen | Human | SELP | 6403 | selectin P (granule membrane protein 140kDa, antigen CD62) | Compared with those treated with bivalirudin, patients treated with UFH+E exhibited a 45% decrease in the capacity of platelets to bind fibrinogen | Human | S100A9 | 6280 | S100 calcium binding protein A9 | S100A9 stimulates shedding of L-selectin, up-regulates and activates Mac-1/CD11b, induces neutrophil adhesion to fibrinogen in vitro, and is involved in neutrophil migration to in vivo inflammatory sites | Human | S100A8 | 6279 | S100 calcium binding protein A8 | S100A8 stimulates shedding of L-selectin, up-regulates and activates Mac-1/CD11b, induces neutrophil adhesion to fibrinogen in vitro, and is involved in neutrophil migration to in vivo inflammatory sites | Human | MAPK3 | 5595 | mitogen-activated protein kinase 3 | Inhibition of chemotaxis by PPAR-gamma ligands correlated with decreases in extracellular signal-regulated kinase-1 and -2 activation, actin polymerization, and adherence to a fibrinogen substrate | Human | PLG | 5340 | plasminogen | closely related alpha(M)beta(2) ligands, plasminogen and angiostatin, derived from plasminogen, as well as fibrinogen and its two derivative alpha(M)beta(2) recognition peptides, P1 and P2-C, differed markedly in their effects on neutrophil apoptosis | Human | PLAUR | 5329 | plasminogen activator, urokinase receptor | uPAR up-regulated the Mac-1 adhesion to fibrinogen, and focal adhesion kinase and MAPK were involved in this regulation | Human | PLAT | 5327 | plasminogen activator, tissue | heart rate recovery after exercise was inversely correlated with plasminogen activator inhibitor 1 (PAI-1) activity, tissue plasminogen activator (t-PA) antigen, and fibrinogen Fibrinogen and fibrin modulate the activity of tPA differently in regard to their activation of plasminogen and inhibition by PAI-1 t-PA antigen concentration (P =.001), fibrinogen and time on dialysis prior to transplantation (P <.05) were positive independent predictors of carotid intima media thickness in kidney transplantation | Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | PAI-1 directly bound to the alpha(20-88) and thus concentrated in fibrinogen/fibrin Fibrinogen and fibrin modulate the activity of tPA differently in regard to their activation of plasminogen and inhibition by PAI-1 Heart rate recovery after exercise was inversely correlated with plasminogen activator inhibitor 1 (PAI-1) activity, tissue plasminogen activator (t-PA) antigen, and fibrinogen | Human | P2RY2 | 5029 | purinergic receptor P2Y, G-protein coupled, 2 | Fibrinogen is required for nucleotide-induced primary granule release from human neutrophils through the P2Y2 receptor without a role for arachidonic acid metabolites | Human | NFKB1 | 4790 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Fibrinogen exposure resulted in increase in NF-kappaB activation and up-regulation of expression of MCP-1 and of IL-8, a response linked to the p50, p65 and c-Rel components of NF-kappaB | Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Manganese and activators of the ERK pathway cooperated in HT29-D4 cell adhesion to fibrinogen | Human | LPA | 4018 | lipoprotein, Lp(a) | The Apo(a) Kringle V-protease domain binds to plasmin-treated fibrinogen, competing with and sharing binding sites with Lp(a), and possibly participating in the Lp(a)-fibrinogen interaction | Human | ITGB3 | 3690 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | interactions between alphaIIbbeta3 & ligands echistatin & fibrinogen's gamma-module; studies differentiate priming ligands, which bind to resting receptor & perturb its conformation, from regulated ligands, where binding-site remodeling must first occur identification of binding site in gamma C-domain of fibrinogen the surface density of fibrinogen affects alpha II b beta 3-mediated platelet signaling, adhesion, and spreading A novel 196Leu to Pro substitution in the beta3 subunit of the alphaIIbbeta3 integrin in a patient with a variant form of Glanzmann thrombasthenia prevents GPIIbIIIa from binding fibrinogen when platelets are activated | Human | ITGB2 | 3689 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | adhesion of human neutrophil granulocytes to fibrinogen is greatly increased by plasmin digestion in a mode where alphaXbeta2 dominates the integrin-dependent binding The mechanism that regulates the unmasking of the integrin beta 2 cryptic binding site in the gamma C-domain of fibrinogen has been identified studies of the interaction of the ligand binding alphaMI-domain of alphaMbeta2 with the D fragment of fibrinogen, which has multiple binding sites for integrin alphaMbeta2 Fibrinogen-CD11b/CD18 interaction activates the NF-kappa B pathway and delays apoptosis in human neutrophils | Human | ITGB1 | 3688 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | identification of binding site in gamma C-domain of fibrinogen | Human | ITGAX | 3687 | integrin, alpha X (complement component 3 receptor 4 subunit) | adhesion of human neutrophil granulocytes to fibrinogen is greatly increased by plasmin digestion in a mode where alphaXbeta2 dominates the integrin-dependent binding | Human | ITGAM | 3684 | integrin, alpha M (complement component 3 receptor 3 subunit) | studies of the interaction of the ligand binding alphaMI-domain of alphaMbeta2 with the D fragment of fibrinogen, which has multiple binding sites for integrin alphaMbeta2 uPAR up-regulated the Mac-1 adhesion to fibrinogen, and focal adhesion kinase and MAPK were involved in this regulation Mac-1 molecules mediated cell adhesion predominantly to fibrinogen, and its early degradation products, fragments X and Y The mechanism that regulates the unmasking of the integrin alpha M cryptic binding site in the gamma C-domain of fibrinogen has been identified |
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