Human | BCAN | 63827 | brevican | Authors describe the expression of BEHAB/brevican in human brain and characterize two novel glioma-specific isoforms which are generated by differential glycosylation and are absent from normal adult brain and other neuropathologies |
Human | BACE1 | 23621 | beta-site APP-cleaving enzyme 1 | altered cholesterol metabolism and amyloid precursor protein trafficking mediated by ABC transporter 8 may contribute to the accelerated onset of Alzheimer's disease neuropathology in Down syndrome |
Human | SIRT1 | 23411 | sirtuin 1 | expression of SIRT1 in the brain resulted in decreased ROCK1 expression and elevated alpha-secretase activity; SIRT1 activation in the brain is a novel mechanism through which calorie restriction may influence Alzheimer disease amyloid neuropathology |
Human | GAB2 | 9846 | GRB2-associated binding protein 2 | Our findings suggest that GAB2 modifies LOAD risk in APOE epsilon4 carriers and influences Alzheimer's neuropathology |
Human | ABCG1 | 9619 | ATP-binding cassette, sub-family G (WHITE), member 1 | altered cholesterol metabolism and amyloid precursor protein trafficking mediated by ABCG1 may contribute to the accelerated onset of Alzheimer's disease neuropathology in Down syndrome |
Human | YWHAZ | 7534 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | a 14-3-3 zeta implication in the Alzheimer's neuropathology |
Human | TP73 | 7161 | tumor protein p73 | The interplay between Tat and p73 may affect Tat contribution to apoptotic events in the brain, limiting its involvement in the neuropathology often observed in the brains of HIV-1 patients |
Human | SOD1 | 6647 | superoxide dismutase 1, soluble | impaired ability to form, or retain, the C57-C146 bond in vivo is predicted to increase the cellular load of marginally stable apoSOD monomers, which may have implications for the amytrophic lateral sclerosis neuropathology |
Human | ATXN1 | 6310 | ataxin 1 | These data provide insight into the function of ATXN1 and suggest that SCA1 neuropathology depends on native, not novel, protein interactions |
Human | PTGS1 | 5742 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | COX enzymes potentiate inflammatory neuropathology in Alzheimer's disease (AD) brain |
Human | PRNP | 5621 | prion protein | Polymorphism of the codon 129 of the prion protein (PrP) gene and neuropathology of cerebral ageing neuropathology and the characteristics of the PrPSc associated with the H187R mutation in Gerstmann-Straussler-Scheinker disease |
Human | PRKCE | 5581 | protein kinase C, epsilon | increased neuronal PKCepsilon activity can promote Abeta clearance and reduce AD neuropathology through increased endothelin-converting enzyme activity |
Human | PDYN | 5173 | prodynorphin | Alzheimer's disease (AD) brains display robustly elevated levels of dynorphin A and no differences in dynorphin B and nociceptin compared to controls, suggesting a role for this neuropeptide in AD neuropathology |
Human | MMP2 | 4313 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Glutamate-induced MMP-2 activity may contribute to neuropathology in various CNS diseases and may generate misleading data in pathogen studies where Middlebrook 7H9 is the culture medium |
Human | MME | 4311 | membrane metallo-endopeptidase | These findings demonstrate an important role for proteolysis in determining the levels of Abeta and Abeta-associated neuropathology in vivo and support the hypothesis that primary defects in Abeta clearance can cause or contribute to LOAD pathogenesis |
Human | MAPT | 4137 | microtubule-associated protein tau | Neuropathology shows neuronal loss in basal ganglia, brainstem, and cerebellum |
Human | HMGB1 | 3146 | high mobility group box 1 | this provides an appraisal of the emerging roles of HMGB1 in neuropathology and the neuroinflammatory response--REVIEW |
Human | HTT | 3064 | huntingtin | Regulated expression of huntingtin (Huntington disease) induced reversible striatal neuropathology typical for Huntington disease Studies using transgenic mice and monkeys suggest that the neuropathology of Huntington's disease is due to the accumulation of N-terminal mutant htt fragments of mutant htt |
Human | ERG | 2078 | v-ets avian erythroblastosis virus E26 oncogene homolog | ERG plays a role in the development of Alzheimer's disease (AD)-like neuropathology in Down syndrome and in pathogenesis of AD per se; the manifold increase of ERG in both disorders may form a pivotal pathogenetic link |
Human | EPHX1 | 2052 | epoxide hydrolase 1, microsomal (xenobiotic) | The present study demonstrates a significant increase in mEH expression in the AD hippocampus, a region showing abundant neuropathology in AD |
Human | ECE1 | 1889 | endothelin converting enzyme 1 | increased neuronal PKCepsilon activity can promote Abeta clearance and reduce AD neuropathology through increased endothelin-converting enzyme activity |
Human | TOR1A | 1861 | torsin family 1, member A (torsin A) | Increased striatal dopamine turnover in hMT1 mice suggests that the nigrostriatal pathway may be a site of functional neuropathology in DYT1 dystonia |
Human | DYRK1A | 1859 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | In this review experimental evidence is compiled and discussed which supports the involvement of MNB/DYRK1A in several neuropathologies and cognitive deficits of Down syndrome |
Human | CTGF | 1490 | connective tissue growth factor | CTGF expression in the brain might have a role in Alzheimer's disease clinical progression and neuropathology |
Human | BACH1 | 571 | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | BACH1 plays a role in the development of Alzheimer's disease (AD)-like neuropathology in Down syndrome and in pathogenesis of AD per se |