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Details
Link-It Detail - Disease - Oncogene Activation
Debug Stats
  • ### Total Build Time: 19 ms 8.561 KB
  • CONCEPT_NAME gt=4 ms Completed: 4 ms rowSize= 336 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 583 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=3 ms Completed: 3 ms rowSize= 1.218 KB
  • CONCEPT_GENES gt=9 ms Completed: 9 ms rowSize= 5.222 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.153 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Oncogene Activation C1518575
Definition (1)
Any DNA sequence alteration process occurring in a proto-oncogene, resulting in loss of regulation of the gene product, and predisposing the cell to neoplastic transformation. Proto-oncogenes are ordinarilly involved in transduction of signals that regulate cell growth and differentiation. Activation of such genes overrides the normal mechanisms of regulation and is an important step in the process of cellular transformation.
Relationships (1)

Relation Types:
diso_​to_​diso : 1


Relationships:
process_​includes_​biological_​process : 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISOprocess_includes_biological_processimg CELL TRANSFORM NEOPL C0007621
Genes (4)

Species:
human : 4
SpeciesGeneGeneIdGene NameEvidence
HumanRASSF111186Ras association (RalGDS/AF-6) domain family member 1
img GENERIF, Score=875, Pubmed Id: 15867363, UMLKSK CUI: C1518575
HumanTHOC410189
img GENERIF, Score=1000, Pubmed Id: 17229714, UMLKSK CUI: C1518575
HumanTP537157tumor protein p53
img GENERIF, Score=1000, Pubmed Id: 16990795, UMLKSK CUI: C1518575
HumanBCL6604B-cell CLL/lymphoma 6
img GENERIF, Score=861, Pubmed Id: 14654791, UMLKSK CUI: C1518575
img GENERIF, Score=840, Pubmed Id: 14655758, UMLKSK CUI: C1518575
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C1518575Oncogene Activation0self